Asiaticoside
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Asiaticoside
- DrugBank Accession Number
- DB14081
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 959.133
Monoisotopic: 958.513730292 - Chemical Formula
- C48H78O19
- Synonyms
- Asiaticosid
- External IDs
- BA 2742
- BA-2742
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Madecassol
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Centella Scar Ylang Ylang Asiaticoside (0.06 g/15g) + Asiatic acid (0.045 g/15g) + Madecassic acid (0.045 g/15g) Ointment Topical NoTS Co.,Ltd 2016-12-01 2018-12-01 US Dr.Different CICA Metal Asiaticoside (0.012 g/100g) + Madecassoside (0.26 g/100g) Cream Topical Dareun Cosmetics Co., Ltd. 2021-05-01 Not applicable US Karatica Im Cica Essence Pack Asiaticoside (0.01 g/100mL) + Asiatic acid (0.01 g/100mL) + Madecassic acid (0.01 g/100mL) + Madecassoside (0.01 g/100mL) Liquid Topical Karatica Co., Ltd 2019-08-17 Not applicable US Troiareuke Acsen Recovery Asiaticoside (0.009 g/25mL) + Asiatic acid (0.008 g/25mL) + Madecassic acid (0.008 g/25mL) Cream Topical Mk Universal Inc. 2018-05-01 2018-12-01 US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Centella Scar Ylang Ylang Asiaticoside (0.06 g/15g) + Asiatic acid (0.045 g/15g) + Madecassic acid (0.045 g/15g) Ointment Topical NoTS Co.,Ltd 2016-12-01 2018-12-01 US Dr.Different CICA Metal Asiaticoside (0.012 g/100g) + Madecassoside (0.26 g/100g) Cream Topical Dareun Cosmetics Co., Ltd. 2021-05-01 Not applicable US Karatica Im Cica Essence Pack Asiaticoside (0.01 g/100mL) + Asiatic acid (0.01 g/100mL) + Madecassic acid (0.01 g/100mL) + Madecassoside (0.01 g/100mL) Liquid Topical Karatica Co., Ltd 2019-08-17 Not applicable US Troiareuke Acsen Recovery Asiaticoside (0.009 g/25mL) + Asiatic acid (0.008 g/25mL) + Madecassic acid (0.008 g/25mL) Cream Topical Mk Universal Inc. 2018-05-01 2018-12-01 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- PKO39VY215
- CAS number
- 16830-15-2
- InChI Key
- WYQVAPGDARQUBT-FGWHUCSPSA-N
- InChI
- InChI=1S/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-60H,9-19H2,1-7H3/t20-,21+,22+,24-,25-,26-,27-,28-,29+,30+,31-,32-,33+,34-,35-,36-,37-,38-,39+,40-,41+,42+,44+,45+,46-,47-,48+/m1/s1
- IUPAC Name
- (2S,3R,4S,5S,6R)-6-({[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate
- SMILES
- [H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(=O)O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)[C@@]1(C)C[C@@H](O)[C@H](O)[C@@]2(C)CO
References
- General References
- Not Available
- External Links
- KEGG Drug
- D07576
- KEGG Compound
- C15428
- ChemSpider
- 10128466
- BindingDB
- 23211
- 18405
- ChEBI
- 79928
- ChEMBL
- CHEMBL1684590
- ZINC
- ZINC000253529453
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Ointment Topical Liquid Topical Cream Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.798 mg/mL ALOGPS logP 0.73 ALOGPS logP -0.54 Chemaxon logS -3.1 ALOGPS pKa (Strongest Acidic) 11.75 Chemaxon pKa (Strongest Basic) -3.6 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 18 Chemaxon Hydrogen Donor Count 12 Chemaxon Polar Surface Area 315.21 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 232.55 m3·mol-1 Chemaxon Polarizability 102.07 Å3 Chemaxon Number of Rings 8 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 283.6904492 predictedDarkChem Lite v0.1.0
Drug created at June 17, 2018 22:08 / Updated at June 12, 2020 16:53