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Displaying adverse reactions 1 - 25 of 112 in total
Drug Interacting Gene/Enzyme SNP RS ID Allele name Genotype Defining change Adverse Reaction Reference(s)
Abacavir
DB01048
HLA class I histocompatibility antigen protein P5
Gene symbol: HCP5
UniProt: Q6MZN7
rs2395029 HLA-B*5701(G;G)G allelePresence of this SNP is predicative of hypersenitivity reaction when abacavir is given to HIV+ patients.18684101 19483685
Abciximab
DB00054
Integrin beta-3
Gene symbol: ITGB3
UniProt: P05106
rs5918 GPIIIa PlA2(C;C) or (C;T)A2 AlleleAssociated with greater restenosis and risk for subacute coronary thrombosis in patients administered antiplatelet therapy.10732888
Acetylsalicylic acid
DB00945
Leukotriene C4 synthase
Gene symbol: LTC4S
UniProt: Q16873
rs730012 ---(A;C) or (C;C)C alleleAspirin-induced urticaria16433794
Allopurinol
DB00437
HLA class I histocompatibility antigen protein P5
Gene symbol: HCP5
UniProt: Q6MZN7
rs2395029 HLA-B*5701(G;G) or (G;T)G alleleSevere cutaneous adverse reaction23232549
Amiodarone
DB01118
Potassium voltage-gated channel subfamily H member 2
Gene symbol: KCNH2
UniProt: Q12809
Not AvailableMiRP1---KCNE2Channels formed with mutant MiRP1 subunits and HERG showed slower activation, faster deactivation, and increased drug sensitivity and is associated with cardiac arrhythmia.10219239
Amitriptyline
DB00321
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs1045642 ---(T;T)T Allele, homozygousPostural hypotension12082591
Amitriptyline
DB00321
Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261
rs4244285 CYP2C19*2(A;A) or (G;G)G > AThose with the AA or AG genotype are poor metabolizers of amitriptyline20531370
Amitriptyline
DB00321
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4(A;A)G > AIncrease risk of side effects and decrease drug metabolism18070221
Amitriptyline
DB00321
Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635
rs3892097 CYP2D6*4(A;A)G > AIncrease risk of side effects and decrease drug metabolism9918137
Atazanavir
DB01072
UDP-glucuronosyltransferase 1-1
Gene symbol: UGT1A1
UniProt: P22309
rs3064744 UGT1A1*28(TA;TA)TA pair insertionHyperbilirubinemia26417955
Atazanavir
DB01072
UDP-glucuronosyltransferase 1-1
Gene symbol: UGT1A1
UniProt: P22309
rs8175347 UGT1A1*37(TA;TA)TA pair insertionHyperbilirubinemia26417955
Atazanavir
DB01072
UDP-glucuronosyltransferase 1-1
Gene symbol: UGT1A1
UniProt: P22309
rs887829 UGT1A1*80(T;T)C > THyperbilirubinemia26417955
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1800462 TPMT*2(G;G) or (C;G)G AlleleMyelosuppression16509759
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1800460 TPMT*3A(A;A) or (A;G)A AlleleMyelosuppression16509759
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1142345 TPMT*3C(G;G) or (A;G)G AlleleMyelosuppression16509759
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1142345 TPMT*3C(C;C) or (C;T)T > CPatients with CC or CT genotype have decreased inactivation of thiopurines and increased risk of toxicity22846425
Azathioprine
DB00993
Thiopurine S-methyltransferase
Gene symbol: TPMT
UniProt: P51580
rs1142345 TPMT*3C(C;C) or (C;T)T > CPatients with CC or CT genotype have decreased inactivation of thiopurines and increased risk of toxicity9103127
Caffeine
DB00201
Cytochrome P450 1A2
Gene symbol: CYP1A2
UniProt: P05177
rs762551 ---(C;C) or (A;C)C alleleMyocardial infarction16522833
Capecitabine
DB01101
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882
rs3918290 DPYD*2A(A;A) or (A;G)G > AAssociated with 5-fluoracil toxicity23988873
Capecitabine
DB01101
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882
rs55886062 DPYD*13(C;C) or (A;C)A > CAssociated with 5-fluoracil toxicity23988873
Capecitabine
DB01101
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882
rs67376798 ---(A;A) or (A;T)T > AAssociated with 5-fluoracil toxicity23988873
Capecitabine
DB01101
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882
rs1801158 DPYD*4(G;G) or (A:G)G > AAssociated with toxicity23988873
Capecitabine
DB01101
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882
rs1801159 DPYD*5(G;G) or (A;G)A > GAssociated with toxicity23988873
Capecitabine
DB01101
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882
rs1801160 DPYD*6(A;A) or (A;G)G > AAssociated with 5-fluoracil toxicity23988873
Capecitabine
DB01101
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene symbol: DPYD
UniProt: Q12882
rs1801265 DPYD*9A(C;C) or (C;T)T > CAssociated with toxicity23988873
Displaying adverse reactions 1 - 25 of 112 in total