Marfan Syndrome

Also known as: Marfan's syndrome / Syndrome, Marfan / Marfan's syndrome, unspecified / Situs inversus

DrugDrug NameDrug Description
DB00678LosartanLosartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Losartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.
DrugDrug NamePhaseStatusCount
DB00335Atenolol2Completed1
DB00678Losartan2Completed1
DB00678Losartan2Unknown Status1
DB09026Aliskiren3Completed1
DB00335Atenolol3Completed3
DB00335Atenolol3Unknown Status1
DB00678Losartan3Completed2
DB00678Losartan3Recruiting1
DB00678Losartan3Terminated1
DB00678Losartan3Unknown Status2
DB04861Nebivolol3Unknown Status1
DB00790Perindopril3Completed1
DB00335Atenolol4Completed1
DB00790Perindopril4Completed1
DB00661Verapamil4Completed1