Hepatic Encephalopathy

Also known as: Hepatic Encephalopathy (HE) / Encephalopathy, Hepatic / Encephalopathy hepatic / Hepatic encephalopathy (disorder) / Portal systemic encephalopathy (disorder) / Hepatic failure, unspecified with coma / Hepatic coma / Hepatic coma (disorder) / Coma hepatic

DrugDrug NameDrug Description
DB12942LactitolAn orally administered osmotic laxative used to treat chronic idiopathic constipation.
DB00581LactuloseA disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy.
DB00134MethionineAn amino acid commonly found as a component in total parenteral nutrition.
DB00129OrnithineAn amino acid commonly found as a component in total parenteral nutrition.
DB01220RifaximinA rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults.
DB14015Sodium bisulfiteAn ingredient in parenteral nutrition products for patients with severe liver disorders.
DB00161ValineAn amino acid commonly found as a component of total parenteral nutrition.
DrugDrug NameTargetType
DB00581LactuloseEvolved beta-galactosidase subunit alphatarget
DB00134MethionineMethionine synthase reductasetarget
DB00134MethionineMethionine synthasetarget
DB00134MethionineMethionine aminopeptidase 2target
DB00134MethionineBetaine--homocysteine S-methyltransferase 1target
DB00134MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2target
DB00134MethionineGlutamine synthetaseenzyme
DB00134MethionineMethylenetetrahydrofolate reductaseenzyme
DB00134MethionineMonocarboxylate transporter 10transporter
DB00134MethionineS-adenosylmethionine synthase isoform type-2enzyme
DB00134MethionineMethionine-R-sulfoxide reductase B2, mitochondrialenzyme
DB00134MethionineS-adenosylmethionine synthase isoform type-1enzyme
DB00134MethionineMethionine-R-sulfoxide reductase B1enzyme
DB00134MethionineMitochondrial peptide methionine sulfoxide reductaseenzyme
DB00134MethionineMethionine--tRNA ligase, cytoplasmicenzyme
DB00134MethionineMethionine--tRNA ligase, mitochondrialenzyme
DB00134MethionineMethionine adenosyltransferase 2 subunit betaenzyme
DB00134MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2enzyme
DB00129OrnithineOrnithine aminotransferase, mitochondrialtarget
DB00129OrnithineOrnithine carbamoyltransferase, mitochondrialtarget
DB00129OrnithineArginase-1target
DB00129OrnithineOrnithine decarboxylase antizyme 1target
DB00129OrnithineLow affinity cationic amino acid transporter 2target
DB00129OrnithineMitochondrial ornithine transporter 2target
DB00129OrnithineHigh affinity cationic amino acid transporter 1target
DB00129OrnithineArginase-2, mitochondrialtarget
DB00129OrnithineMitochondrial ornithine transporter 1target
DB00129OrnithineGlycine amidinotransferase, mitochondrialtarget
DB01220RifaximinDNA-directed RNA polymerase subunit betatarget
DB01220RifaximinNuclear receptor subfamily 1 group I member 2target
DB01220RifaximinCytochrome P450 3A4enzyme
DB01220RifaximinCytochrome P450 2C19enzyme
DB01220RifaximinCytochrome P450 2C8enzyme
DB00161ValinePropionyl-CoA carboxylase beta chain, mitochondrialtarget
DB00161ValineBranched-chain-amino-acid aminotransferase, cytosolictarget
DB00161ValineValine--tRNA ligasetarget
DB00161ValineMonocarboxylate transporter 10transporter
DB00161ValineValine--tRNA ligaseenzyme
DB00161ValinePropionyl-CoA carboxylase beta chain, mitochondrialenzyme
DB00161ValineBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DrugDrug NamePhaseStatusCount
DB00803Colistin0Not Yet Recruiting1
DB00581Lactulose0Not Yet Recruiting1
DB01220Rifaximin0Recruiting1
DB09393Amino acids1Completed1
DB09393Amino acids1Recruiting1
DB08909Glycerol phenylbutyrate1Completed1
DB00581Lactulose1Completed1
DB00581Lactulose1Recruiting1
DB17743Fecal microbiota1 / 2Completed1
DB01205Flumazenil1 / 2Withdrawn1
DB00203Sildenafil1 / 2Unknown Status1
DB05269Activated charcoal2Completed1
DB09278Activated charcoal2Completed1
DB00062Albumin human2Completed1
DB00062Albumin human2Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Recruiting1
DB03793Benzoic acid2Terminated1
DB01075Diphenhydramine2Recruiting1
DB17743Fecal microbiota2Active Not Recruiting1
DB06170Glycerol phenylbutyrate2Completed1
DB16555Lactoferrin2Not Yet Recruiting1
DB00581Lactulose2Completed3
DB00581Lactulose2Unknown Status1
DB00959Methylprednisolone2Recruiting1
DB14644Methylprednisolone hemisuccinate2Recruiting1
DB00916Metronidazole2Unknown Status1
DB00507Nitazoxanide2Unknown Status1
DB00129Ornithine2Completed1
DB09269Phenylacetic acid2Terminated1
DB00860Prednisolone2Recruiting1
DB11753Rifamycin2Completed1
DB01220Rifaximin2Completed1
DB01220Rifaximin2Unknown Status2
DB09153Sodium chloride2Recruiting1
DB17794VE3032Active Not Recruiting1
DB00512Vancomycin2Active Not Recruiting1
DB00437Allopurinol2 / 3Recruiting1
DB01076Atorvastatin2 / 3Recruiting1
DB00736Esomeprazole2 / 3Unknown Status1
DB00581Lactulose2 / 3Completed1
DB00581Lactulose2 / 3Unknown Status1
DB00507Nitazoxanide2 / 3Unknown Status1
DB00641Simvastatin2 / 3Recruiting1
DB06151Acetylcysteine3Completed1
DB00581Lactulose3Recruiting1
DB00581Lactulose3Terminated1
DB00581Lactulose3Unknown Status1
DB00581Lactulose3Withdrawn1
DB13855Nifuroxazide3Recruiting1
DB00507Nitazoxanide3Recruiting1
DB00129Ornithine3Completed1
DB00129Ornithine3Withdrawn1
DB01220Rifaximin3Completed2
DB01220Rifaximin3Recruiting3
DB01220Rifaximin3Terminated1
DB01220Rifaximin3Withdrawn1
DB06212Tolvaptan3Completed1
DB00062Albumin human4Completed3
DB00062Albumin human4Unknown Status1
DB01136Carvedilol4Completed1
DB04465Lactose4Completed1
DB00581Lactulose4Completed4
DB00581Lactulose4Not Yet Recruiting1
DB00581Lactulose4Recruiting2
DB00581Lactulose4Terminated1
DB00581Lactulose4Unknown Status4
DB00331Metformin4Unknown Status1
DB00683Midazolam4Unknown Status1
DB00211Midodrine4Completed1
DB00129Ornithine4Completed4
DB00129Ornithine4Recruiting1
DB00129Ornithine4Unknown Status1
DB09287Polyethylene glycol4Unknown Status2
DB00761Potassium chloride4Unknown Status1
DB00818Propofol4Unknown Status1
DB00571Propranolol4Completed1
DB01220Rifaximin4Completed3
DB01220Rifaximin4Recruiting1
DB01220Rifaximin4Terminated2
DB01390Sodium bicarbonate4Unknown Status1
DB09153Sodium chloride4Completed1
DB09153Sodium chloride4Unknown Status1
DB09393Amino acidsNot AvailableUnknown Status1
DB00199ErythromycinNot AvailableUnknown Status1
DB00581LactuloseNot AvailableCompleted6
DB00581LactuloseNot AvailableWithdrawn1
DB13758MeclofenoxateNot AvailableUnknown Status1
DB00994NeomycinNot AvailableUnknown Status1
DB00129OrnithineNot AvailableCompleted1
DB09287Polyethylene glycolNot AvailableCompleted1
DB09287Polyethylene glycolNot AvailableWithdrawn1
DB00761Potassium chlorideNot AvailableCompleted1
DB00761Potassium chlorideNot AvailableWithdrawn1
DB01220RifaximinNot AvailableCompleted5
DB01390Sodium bicarbonateNot AvailableCompleted1
DB01390Sodium bicarbonateNot AvailableWithdrawn1
DB09153Sodium chlorideNot AvailableCompleted1
DB09153Sodium chlorideNot AvailableWithdrawn1
DB09472Sodium sulfateNot AvailableCompleted1
DB09472Sodium sulfateNot AvailableWithdrawn1
DB09270UbidecarenoneNot AvailableUnknown Status1