Diabetic Nephropathies

Also known as: Diabetic nephropathy / Nephropathy, Diabetic / Diabetic nephropathy NOS / Diabetic renal disease / Diabetes with renal manifestations

DrugDrug NameDrug Description
DB00542BenazeprilAn ACE inhibitor prodrug used to treat hypertension.
DB08907CanagliflozinA sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus (DM). Also used to reduce the risk of major cardiovascular events in patients with established cardiovascular disease and type 2 DM.
DB00796Candesartan cilexetilAn angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy.
DB01197CaptoprilAn ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.
DB00584EnalaprilA prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure.
DB09477EnalaprilatAn antihypertensive agent used for the management of hypertension when oral therapy is not practical.
DB00876EprosartanAn ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.
DB00492FosinoprilAn ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.
DB01029IrbesartanAn angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure.
DB00722LisinoprilAn ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction.
DB00678LosartanAn angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke.
DB00275OlmesartanAn angiotensin receptor blocker (ARB) used in the treatment of hypertension.
DB00790PerindoprilAn ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction.
DB00881QuinaprilAn ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
DB00178RamiprilAn ACE inhibitor used for the management of hypertension and the reduction of cardiovascular mortality following myocardial infarction in hemodynamically stable patients with clinical signs of congestive heart failure.
DB00966TelmisartanAn ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.
DB00519TrandolaprilA prodrug of an ACE inhibitor used to treat hypertension, congestive heart failure, and to improve survival following a myocardial infarction.
DB00177ValsartanAn angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.
DrugDrug NameTargetType
DB00542BenazeprilAngiotensin-converting enzymetarget
DB00542BenazeprilMethylenetetrahydrofolate reductaseenzyme
DB00542BenazeprilSolute carrier family 15 member 1transporter
DB00542BenazeprilSolute carrier family 15 member 2transporter
DB08907CanagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB08907CanagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB08907CanagliflozinCytochrome P450 3A4enzyme
DB08907CanagliflozinSodium/glucose cotransporter 2target
DB08907CanagliflozinP-glycoprotein 1transporter
DB08907CanagliflozinCanalicular multispecific organic anion transporter 1transporter
DB08907CanagliflozinAlpha-1-acid glycoprotein 1carrier
DB08907CanagliflozinATP-binding cassette sub-family G member 2transporter
DB00796Candesartan cilexetilType-1 angiotensin II receptortarget
DB00796Candesartan cilexetilCytochrome P450 2C8enzyme
DB00796Candesartan cilexetilCytochrome P450 2C9enzyme
DB00796Candesartan cilexetilP-glycoprotein 1transporter
DB00796Candesartan cilexetilUDP-glucuronosyltransferase 1-3enzyme
DB00796Candesartan cilexetilProstaglandin G/H synthase 1enzyme
DB01197CaptoprilAngiotensin-converting enzymetarget
DB01197CaptoprilSerum albumincarrier
DB01197Captopril72 kDa type IV collagenasetarget
DB01197CaptoprilMatrix metalloproteinase-9target
DB01197CaptoprilP-glycoprotein 1transporter
DB01197CaptoprilSolute carrier family 15 member 1transporter
DB01197CaptoprilSolute carrier family 22 member 6transporter
DB01197CaptoprilLeukotriene A-4 hydrolasetarget
DB01197CaptoprilB1 bradykinin receptortarget
DB00584EnalaprilAngiotensin-converting enzymetarget
DB00584EnalaprilP-glycoprotein 1transporter
DB00584EnalaprilSolute carrier family 15 member 1transporter
DB00584EnalaprilSolute carrier family 22 member 6transporter
DB00584EnalaprilSolute carrier family 22 member 8transporter
DB00584EnalaprilSolute carrier family 22 member 7transporter
DB00584EnalaprilSolute carrier organic anion transporter family member 1A2transporter
DB00584EnalaprilSerum albumincarrier
DB09477EnalaprilatAngiotensin-converting enzymetarget
DB09477EnalaprilatB1 bradykinin receptortarget
DB00876EprosartanType-1 angiotensin II receptortarget
DB00876EprosartanCanalicular multispecific organic anion transporter 1transporter
DB00492FosinoprilAngiotensin-converting enzymetarget
DB00492FosinoprilSolute carrier family 15 member 1transporter
DB00492FosinoprilSolute carrier family 15 member 2transporter
DB01029IrbesartanType-1 angiotensin II receptortarget
DB01029IrbesartanTranscription factor AP-1target
DB01029IrbesartanCytochrome P450 2C9enzyme
DB01029IrbesartanCytochrome P450 2C8enzyme
DB01029IrbesartanUDP-glucuronosyltransferase 1-3enzyme
DB01029IrbesartanProstaglandin G/H synthase 1enzyme
DB01029IrbesartanCytochrome P450 3A4enzyme
DB01029IrbesartanSerum albumincarrier
DB01029Irbesartanalpha1-acid glycoproteincarrier
DB00722LisinoprilAngiotensin-converting enzymetarget
DB00722LisinoprilSolute carrier family 15 member 1transporter
DB00722LisinoprilSolute carrier family 15 member 2transporter
DB00722LisinoprilRenintarget
DB00678LosartanType-1 angiotensin II receptortarget
DB00678LosartanCytochrome P450 3A4enzyme
DB00678LosartanCytochrome P450 2C9enzyme
DB00678LosartanP-glycoprotein 1transporter
DB00678LosartanSolute carrier family 22 member 6transporter
DB00678LosartanUDP-glucuronosyltransferase 1-1enzyme
DB00678LosartanUDP-glucuronosyltransferase 1-3enzyme
DB00678LosartanUDP-glucuronosyltransferase 1-10enzyme
DB00678LosartanUDP-glucuronosyltransferase 2B7enzyme
DB00678LosartanUDP-glucuronosyltransferase 2B17enzyme
DB00678LosartanCytochrome P450 2C19enzyme
DB00678LosartanSerum albumincarrier
DB00678LosartanSolute carrier family 22 member 12transporter
DB00678LosartanSolute carrier family 2, facilitated glucose transporter member 9transporter
DB00678LosartanBile salt export pumptransporter
DB00678LosartanCytochrome P450 2C8enzyme
DB00275OlmesartanType-1 angiotensin II receptortarget
DB00275OlmesartanCanalicular multispecific organic anion transporter 1transporter
DB00275OlmesartanSolute carrier organic anion transporter family member 1B3transporter
DB00275OlmesartanSolute carrier organic anion transporter family member 1B1transporter
DB00275OlmesartanBile salt export pumptransporter
DB00275OlmesartanSerum albumincarrier
DB00790PerindoprilAngiotensin-converting enzymetarget
DB00790PerindoprilSolute carrier family 15 member 1transporter
DB00790PerindoprilSolute carrier family 15 member 2transporter
DB00790PerindoprilCholinesteraseenzyme
DB00790PerindoprilSecreted frizzled-related protein 4target
DB00881QuinaprilAngiotensin-converting enzymetarget
DB00881QuinaprilSolute carrier family 15 member 1transporter
DB00881QuinaprilSolute carrier family 15 member 2transporter
DB00881QuinaprilSolute carrier family 22 member 8transporter
DB00881QuinaprilLiver carboxylesterase 1enzyme
DB00881QuinaprilSerum albumincarrier
DB00178RamiprilAngiotensin-converting enzymetarget
DB00178RamiprilSolute carrier family 15 member 1transporter
DB00178RamiprilSolute carrier family 15 member 2transporter
DB00178RamiprilCholinesteraseenzyme
DB00178RamiprilB1 bradykinin receptortarget
DB00966TelmisartanType-1 angiotensin II receptortarget
DB00966TelmisartanPeroxisome proliferator-activated receptor gammatarget
DB00966TelmisartanP-glycoprotein 1transporter
DB00966TelmisartanCanalicular multispecific organic anion transporter 1transporter
DB00966TelmisartanATP-binding cassette sub-family G member 2transporter
DB00966TelmisartanCytochrome P450 2C19enzyme
DB00966TelmisartanBile salt export pumptransporter
DB00966TelmisartanUDP-glucuronosyltransferase 1-3enzyme
DB00519TrandolaprilAngiotensin-converting enzymetarget
DB00519TrandolaprilSolute carrier family 15 member 1transporter
DB00519TrandolaprilSolute carrier family 15 member 2transporter
DB00519TrandolaprilLiver carboxylesterase 1enzyme
DB00177ValsartanType-1 angiotensin II receptortarget
DB00177ValsartanCytochrome P450 2C9enzyme
DB00177ValsartanSolute carrier organic anion transporter family member 1B3transporter
DB00177ValsartanSolute carrier organic anion transporter family member 1B1transporter
DB00177ValsartanCanalicular multispecific organic anion transporter 1transporter
DrugDrug NamePhaseStatusCount
DB00678Losartan0Completed1
DB02709Resveratrol0Completed1
DB06724Calcium carbonate1Completed1
DB00700Eplerenone1Recruiting1
DB15122PCS-4991Completed1
DB14952Pamrevlumab1Completed1
DB00658Sevelamer1Completed1
DB00345Aminohippuric acid1 / 2Active Not Recruiting1
DB00345Aminohippuric acid1 / 2Recruiting1
DB15024Apararenone1 / 2Completed2
DB01394Colchicine1 / 2Recruiting1
DB01362Iohexol1 / 2Active Not Recruiting1
DB01362Iohexol1 / 2Recruiting1
DB04951Pirfenidone1 / 2Completed1
DB06151Acetylcysteine2Completed1
DB12497Alagebrium2Terminated1
DB09026Aliskiren2Completed1
DB15024Apararenone2Active Not Recruiting1
DB15024Apararenone2Completed3
DB06199Atrasentan2Completed4
DB05983Bardoxolone methyl2Completed2
DB12739Bindarit2Completed1
DB06724Calcium carbonate2Completed1
DB00169Cholecalciferol2Active Not Recruiting1
DB01394Colchicine2Unknown Status1
DB01285Corticotropin2Completed1
DB12116Epigallocatechin gallate2Completed1
DB00700Eplerenone2Completed1
DB15207Esaxerenone2Completed1
DB00492Fosinopril2Completed1
DB14307Green tea leaf2Completed1
DB00678Losartan2Completed1
DB14375Milk thistle2Completed1
DB00688Mycophenolate mofetil2Completed2
DB00275Olmesartan2Completed1
DB11736PF-004897912Completed1
DB14955PF-046348172Completed1
DB14952Pamrevlumab2Terminated1
DB00910Paricalcitol2Completed1
DB09208Pegloticase2Not Yet Recruiting1
DB12520Plozalizumab2Withdrawn1
DB01599Probucol2Completed1
DB00073Rituximab2Completed1
DB00658Sevelamer2Completed1
DB01685Topiroxostat2Completed1
DB04991XL7842Completed1
DB06151Acetylcysteine2 / 3Completed1
DB01197Captopril2 / 3Completed1
DB00158Folic acid2 / 3Completed1
DB01029Irbesartan2 / 3Completed1
DB00678Losartan2 / 3Terminated1
DB00806Pentoxifylline2 / 3Completed1
DB00421Spironolactone2 / 3Completed2
DB00437Allopurinol3Active Not Recruiting1
DB06199Atrasentan3Terminated1
DB00136Calcitriol3Recruiting1
DB08907Canagliflozin3Completed1
DB08907Canagliflozin3Recruiting1
DB00343Diltiazem3Withdrawn1
DB09038Empagliflozin3Recruiting1
DB01039Fenofibrate3Recruiting2
DB00722Lisinopril3Completed1
DB00678Losartan3Completed2
DB00688Mycophenolate mofetil3Unknown Status1
DB01115Nifedipine3Completed1
DB01115Nifedipine3Withdrawn1
DB00275Olmesartan3Completed2
DB04951Pirfenidone3Active Not Recruiting1
DB00178Ramipril3Completed1
DB00641Simvastatin3Completed1
DB00877Sirolimus3Unknown Status1
DB06271Sulodexide3Completed1
DB06271Sulodexide3Terminated1
DB00966Telmisartan3Completed1
DB11094Vitamin D3Recruiting1
DB00945Acetylsalicylic acid4Recruiting1
DB00945Acetylsalicylic acid4Unknown Status1
DB09026Aliskiren4Terminated1
DB00437Allopurinol4Completed1
DB00437Allopurinol4Terminated1
DB00770Alprostadil4Completed1
DB00381Amlodipine4Unknown Status1
DB11842Angiotensin II4Completed1
DB00335Atenolol4Unknown Status1
DB11748Benfotiamine4Completed1
DB00136Calcitriol4Unknown Status1
DB08907Canagliflozin4Recruiting1
DB00169Cholecalciferol4Completed1
DB01166Cilostazol4Completed1
DB00575Clonidine4Unknown Status1
DB00758Clopidogrel4Unknown Status1
DB01285Corticotropin4Completed1
DB00091Cyclosporine4Completed1
DB06292Dapagliflozin4Completed1
DB00590Doxazosin4Unknown Status1
DB09038Empagliflozin4Recruiting1
DB11827Ertugliflozin4Not Yet Recruiting1
DB00016Erythropoietin4Unknown Status1
DB01276Exenatide4Not Yet Recruiting1
DB00695Furosemide4Unknown Status1
DB01120Gliclazide4Completed1
DB00999Hydrochlorothiazide4Unknown Status1
DB01309Insulin Glulisine4Completed1
DB00046Insulin lispro4Not Yet Recruiting1
DB01029Irbesartan4Unknown Status1
DB00722Lisinopril4Completed2
DB09265Lixisenatide4Completed1
DB00678Losartan4Completed2
DB09242Moxonidine4Unknown Status1
DB00401Nisoldipine4Completed1
DB00910Paricalcitol4Completed1
DB00806Pentoxifylline4Completed1
DB01132Pioglitazone4Completed1
DB01599Probucol4Completed1
DB00178Ramipril4Completed2
DB00178Ramipril4Unknown Status2
DB12163Sarpogrelate4Unknown Status1
DB00641Simvastatin4Unknown Status1
DB01390Sodium bicarbonate4Completed1
DB00421Spironolactone4Completed1
DB00421Spironolactone4Unknown Status1
DB06271Sulodexide4Terminated1
DB06271Sulodexide4Unknown Status1
DB00864Tacrolimus4Completed1
DB00966Telmisartan4Completed3
DB00177Valsartan4Completed2
DB00177Valsartan4Terminated2
DB00437AllopurinolNot AvailableRecruiting1
DB00594AmilorideNot AvailableUnknown Status1
DB00345Aminohippuric acidNot AvailableNot Yet Recruiting1
DB11842Angiotensin IINot AvailableCompleted1
DB13919CandesartanNot AvailableCompleted1
DB00482CelecoxibNot AvailableTerminated1
DB01394ColchicineNot AvailableActive Not Recruiting1
DB00584EnalaprilNot AvailableCompleted2
DB01276ExenatideNot AvailableCompleted1
DB00158Folic acidNot AvailableCompleted1
DB00695FurosemideNot AvailableCompleted1
DB01362IohexolNot AvailableNot Yet Recruiting1
DB00583LevocarnitineNot AvailableUnknown Status1
DB06655LiraglutideNot AvailableCompleted1
DB00722LisinoprilNot AvailableCompleted1
DB00678LosartanNot AvailableCompleted5
DB00678LosartanNot AvailableRecruiting1
DB01017MinocyclineNot AvailableUnknown Status1
DB00688Mycophenolate mofetilNot AvailableUnknown Status1
DB01132PioglitazoneNot AvailableCompleted1
DB00421SpironolactoneNot AvailableCompleted1
DB00966TelmisartanNot AvailableRecruiting1
DB00384TriamtereneNot AvailableUnknown Status1
DB14276TurmericNot AvailableCompleted1