Puberty, Precocious

Also known as: Early Puberty / Precocious Puberty / Precocious menstruation / Puberty precocious / Accelerated sexual maturation / Maturation sex accelerated / Precocious puberty NOS / True precocious puberty / Accelerated sexual maturity

DrugDrug NameDrug Description
DB00675TamoxifenOne of the selective estrogen receptor modulators (SERM) with tissue-specific activities for the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium. [PubChem]
DrugDrug NameTargetType
DB00675TamoxifenEstrogen receptor alphatarget
DB00675TamoxifenEstrogen receptor betatarget
DB00675TamoxifenCytochrome P450 2C9enzyme
DB00675TamoxifenCytochrome P450 3A4enzyme
DB00675TamoxifenCytochrome P450 2D6enzyme
DB00675TamoxifenCytochrome P450 2C8enzyme
DB00675TamoxifenCytochrome P450 2B6enzyme
DB00675TamoxifenLiver carboxylesterase 1enzyme
DB00675TamoxifenCytochrome P450 3A5enzyme
DB00675TamoxifenCytochrome P450 1A1enzyme
DB00675TamoxifenCytochrome P450 1A2enzyme
DB00675TamoxifenCytochrome P450 1B1enzyme
DB00675TamoxifenCytochrome P450 2C19enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00675TamoxifenCytochrome P450 3A7enzyme
DB00675TamoxifenMultidrug resistance protein 1transporter
DB00675TamoxifenBile salt export pumptransporter
DB00675TamoxifenATP-binding cassette sub-family G member 2transporter
DB00675TamoxifenCytochrome P450 19A1enzyme
DB00675TamoxifenCytochrome P450 2A6enzyme
DB00675TamoxifenCytochrome P450 2E1enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 1-10enzyme
DB00675TamoxifenSulfotransferase 1A1enzyme
DB00675TamoxifenCanalicular multispecific organic anion transporter 1transporter
DB00675Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
DB00675TamoxifenProtein kinase Ctarget
DB00675TamoxifenAndrogen receptortarget
DB00675TamoxifenPotassium voltage-gated channel subfamily H member 2target
DB00675TamoxifenNuclear receptor subfamily 1 group I member 2target
DB00675TamoxifenEstrogen-related receptor gammatarget
DB00675TamoxifenSex hormone-binding globulintarget
DrugDrug NamePhaseStatusCount
DB06785Ganirelix0Completed1
DB00007Leuprolide0Completed1
DB01006Letrozole1Completed1
DB01217Anastrozole2Active Not Recruiting1
DB01128Bicalutamide2Active Not Recruiting1
DB00947Fulvestrant2Active Not Recruiting1
DB00421Spironolactone2Completed1
DB00894Testolactone2Completed2
DB00007Leuprolide3Completed2
DB06825Triptorelin3Completed2
DB00007Leuprolide4Active Not Recruiting1
DB00644GonadorelinNot AvailableRecruiting1
DB00007LeuprolideNot AvailableCompleted1
DB00007LeuprolideNot AvailableRecruiting1
DB09153Sodium ChlorideNot AvailableRecruiting1
DB00624TestosteroneNot AvailableCompleted1