Keratoconjunctivitis Sicca

Also known as: Conjunctivitis sicca / Keratoconjunctivitis sicca / Sicca, Keratoconjunctivitis / Dry eye / Eyes dry / Tear film insufficiency, unspecified / Dry eye NOS / Dryness of eyes / Dry eyes / Eye dryness

DrugDrug NameDrug Description
DB00091CiclosporinCyclosporine is a lipophilic cyclic polypeptide formed by 11 amino acids that presents powerful immunosuppressive and immunomodulatory properties.[A174088] It is isolated from the fungus _Beauveria nivea_ and it was first formulated as an injectable ethanolic solution in 1980 followed by a vegetable oil formulation in 1990.[A174049] This drug was first discovered in 1970 by Sandoz.[A174076] On the FDA records, the first approved product was registered by the company West-Ward Pharmaceuticals International in 1999.[L5149]
DB00840Hydroxypropyl celluloseHydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis, and as a lubricant for artificial eyes. As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer.
DrugDrug NamePhaseStatusCount
DB06321R-3481Completed1
DB11693Voclosporin1Completed1
DB00091Ciclosporin2Completed2
DB00583Levocarnitine2Not Yet Recruiting1
DB00873Loteprednol2Completed2
DB05511Piclidenoson2Completed1
DB06321R-3482Completed1
DB11656Rebamipide2Completed2
DB00073Rituximab2Completed1
DB09153Sodium chloride2Completed1
DB08895Tofacitinib2Withdrawn1
DB09567Olive oil2 / 3Completed1
DB00091Ciclosporin3Completed1
DB11611Lifitegrast3Completed1
DB00873Loteprednol3Completed2
DB05511Piclidenoson3Completed1
DB11656Rebamipide3Completed2
DB12441Tavilermide3Completed2
DB00091Ciclosporin4Completed1
DB01285Corticotropin4Withdrawn1
DB08818Hyaluronic acid4Completed2
DB11611Lifitegrast4Withdrawn1
DB00873Loteprednol4Completed1
DB00091CiclosporinNot AvailableCompleted1
DB09462GlycerinNot AvailableCompleted1
DB11075HypromelloseNot AvailableCompleted1
DB00125L-ArginineNot AvailableCompleted1
DB00595OxytetracyclineNot AvailableCompleted1
DB00337PimecrolimusNot AvailableCompleted1
DB11077Polyethylene glycol 400Not AvailableCompleted1
DB11078Propylene glycolNot AvailableCompleted1