Retinoblastoma

Also known as: Retinoblastomas / Retinoblastoma NOS

DrugDrug NameDrug Description
DB00958CarboplatinAn organoplatinum compound that possesses antineoplastic activity.
DB00531CyclophosphamidePrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
DB00773EtoposideA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
DB00541VincristineVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
DrugDrug NameTargetType
DB00958CarboplatinDNAtarget
DB00958CarboplatinHigh affinity copper uptake protein 1transporter
DB00958CarboplatinProbable low affinity copper uptake protein 2transporter
DB00958CarboplatinXanthine dehydrogenase/oxidaseenzyme
DB00958CarboplatinMyeloperoxidaseenzyme
DB00958CarboplatinGlutathione S-transferase theta-1enzyme
DB00958CarboplatinMetallothionein-1Aenzyme
DB00958CarboplatinMetallothionein-2enzyme
DB00958CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00958CarboplatinGlutathione S-transferase Penzyme
DB00958CarboplatinGlutathione S-transferase Mu 1enzyme
DB00958CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00958CarboplatinCopper-transporting ATPase 1transporter
DB00958CarboplatinCopper-transporting ATPase 2transporter
DB00958CarboplatinATP-binding cassette sub-family G member 2transporter
DB00958CarboplatinCanalicular multispecific organic anion transporter 1transporter
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide0Recruiting1
DB01041Thalidomide0Recruiting1
DB01143Amifostine1Terminated1
DB01008Busulfan1Completed1
DB01008Busulfan1Terminated2
DB00958Carboplatin1Active Not Recruiting1
DB00958Carboplatin1Completed1
DB00958Carboplatin1Recruiting1
DB09110Coenzyme M1Terminated1
DB00531Cyclophosphamide1Completed1
DB00531Cyclophosphamide1Recruiting1
DB01234Dexamethasone1Recruiting1
DB00773Etoposide1Active Not Recruiting1
DB00773Etoposide1Completed1
DB00773Etoposide1Terminated1
DB00099Filgrastim1Completed1
DB00099Filgrastim1Terminated2
DB01181Ifosfamide1Terminated1
DB01042Melphalan1Active Not Recruiting1
DB01042Melphalan1Terminated2
DB00994Neomycin1Recruiting1
DB00781Polymyxin B1Recruiting1
DB13045Racotumomab1Completed1
DB00020Sargramostim1Terminated1
DB00641Simvastatin1Recruiting1
DB00877Sirolimus1Active Not Recruiting1
DB04572Thiotepa1Terminated2
DB01030Topotecan1Completed1
DB01030Topotecan1Recruiting1
DB00541Vincristine1Active Not Recruiting1
DB01169Arsenic trioxide2Completed1
DB06362Becatecarin2Completed1
DB00958Carboplatin2Active Not Recruiting1
DB00958Carboplatin2Completed4
DB00958Carboplatin2Recruiting3
DB00958Carboplatin2Unknown Status1
DB00958Carboplatin2Withdrawn1
DB00091Ciclosporin2Active Not Recruiting1
DB00515Cisplatin2Completed1
DB00515Cisplatin2Withdrawn1
DB09110Coenzyme M2Completed1
DB09110Coenzyme M2Recruiting1
DB00531Cyclophosphamide2Completed2
DB00531Cyclophosphamide2Recruiting2
DB00531Cyclophosphamide2Withdrawn1
DB00997Doxorubicin2Completed1
DB00997Doxorubicin2Recruiting1
DB11403Emodepside2Recruiting1
DB00773Etoposide2Active Not Recruiting1
DB00773Etoposide2Completed2
DB00773Etoposide2Recruiting3
DB00773Etoposide2Unknown Status1
DB00773Etoposide2Withdrawn1
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Completed4
DB00099Filgrastim2Recruiting1
DB00099Filgrastim2Withdrawn1
DB00125L-Arginine2Recruiting1
DB00650Leucovorin2Withdrawn1
DB01042Melphalan2Recruiting1
DB01042Melphalan2Terminated2
DB00563Methotrexate2Withdrawn1
DB00019Pegfilgrastim2Recruiting1
DB01270Ranibizumab2Unknown Status1
DB00853Temozolomide2Terminated1
DB00853Temozolomide2Withdrawn1
DB04572Thiotepa2Completed2
DB04572Thiotepa2Recruiting1
DB04572Thiotepa2Withdrawn1
DB01030Topotecan2Completed2
DB01030Topotecan2Recruiting1
DB00541Vincristine2Active Not Recruiting1
DB00541Vincristine2Completed2
DB00541Vincristine2Recruiting3
DB00541Vincristine2Withdrawn1
DB00958Carboplatin3Active Not Recruiting1
DB00958Carboplatin3Unknown Status1
DB00531Cyclophosphamide3Active Not Recruiting1
DB00997Doxorubicin3Active Not Recruiting1
DB00773Etoposide3Active Not Recruiting1
DB00773Etoposide3Unknown Status1
DB00099Filgrastim3Active Not Recruiting1
DB01030Topotecan3Active Not Recruiting1
DB00541Vincristine3Active Not Recruiting1
DB00541Vincristine3Unknown Status1
DB00958Carboplatin4Completed1
DB01167Itraconazole4Completed1
DB00020Sargramostim4Recruiting1
DB01008BusulfanNot AvailableRecruiting1
DB00958CarboplatinNot AvailableCompleted1
DB00958CarboplatinNot AvailableRecruiting1
DB00958CarboplatinNot AvailableUnknown Status1
DB00958CarboplatinNot AvailableWithdrawn1
DB09110Coenzyme MNot AvailableRecruiting1
DB00987CytarabineNot AvailableUnknown Status1
DB00773EtoposideNot AvailableRecruiting1
DB00773EtoposideNot AvailableUnknown Status1
DB00099FilgrastimNot AvailableWithdrawn1
DB01181IfosfamideNot AvailableRecruiting1
DB01042MelphalanNot AvailableCompleted1
DB01042MelphalanNot AvailableRecruiting1
DB01229PaclitaxelNot AvailableRecruiting1
DB04572ThiotepaNot AvailableRecruiting1
DB01030TopotecanNot AvailableWithdrawn1
DB01586Ursodeoxycholic acidNot AvailableRecruiting1
DB00541VincristineNot AvailableUnknown Status1
DB00541VincristineNot AvailableWithdrawn1