Premature Ejaculation

Also known as: Premature ejaculation / Premature ejaculation disorder / Ejaculatio praecox / Ejaculation premature

DrugDrug NameDrug Description
DB01086BenzocaineA surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
DB00215CitalopramCitalopram belongs to a class of antidepressant agents known as selective _serotonin-reuptake inhibitors_ (SSRIs) and is widely used to treat the symptoms of depression. Its chemical structure is unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other prescribed antidepressants [FDA label]. Citalopram is also known as _Celexa_, and available in tablet and solution forms [FDA label]. This drug was initially approved by the FDA in 1998 [L5230].
DB00472FluoxetineFluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Fluoxetine may be used to treat major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and in combination with olanzapine for treatment-resistant or bipolar I depression. Fluoxetine is the most anorexic and stimulating SSRI.
DrugDrug NamePhaseStatusCount
DB01175Escitalopram0Unknown Status1
DB11934Epelsiban1Completed1
DB04884Dapoxetine1 / 2Completed1
DB00083Botulinum toxin type A2Terminated1
DB01242Clomipramine2Completed1
DB11934Epelsiban2Completed1
DB04903Pagoclone2Completed1
DB06207Silodosin2Recruiting1
DB00750Prilocaine2 / 3Completed1
DB01242Clomipramine3Completed1
DB08818Hyaluronic acid3Completed1
DB00715Paroxetine3Completed1
DB00715Paroxetine3Not Yet Recruiting1
DB00706Tamsulosin3Not Yet Recruiting1
DB00193Tramadol3Terminated1
DB04884DapoxetineNot AvailableNot Yet Recruiting1
DB04884DapoxetineNot AvailableRecruiting1