Hemophilia A

Also known as: Haemophilia A / Hemophilia As / Classical hemophilia / Factor VIII deficiency / Haemophilia A (Factor VIII) / Hemophilia A (Factor VIII) / Congenital factor VIII disorder

DrugDrug NameDrug Description
DB09329Antihemophilic Factor (Recombinant), PEGylatedAntihemophilic Factor (Recombinant), PEGylated, was approved by the FDA in December 2016 as the product _Adynovate_ [FDA label]. Antihemophilic Factor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor VIII (2,332 amino acids with a molecular weight (MW) of approximately 280 kDa) covalently conjugated with at least one molecule of polyethylene glycol (MW 20 kDa) [FDA label]. It has been created to increase the half-life of factor VIII, which decreases dose frequency and decreases the occurrence of bleeding events [A32067], [A32069], [FDA label]. PEGylation is the covalent attachment of a polyethylene glycol polymer, called PEG, to a drug or protein. PEGylation decreases factor VIII clearance and allowing for an increased duration of drug circulation in the plasma [L1529].
DB13192Antihemophilic factor humanAntihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) and purified from extraneous plasma-derived protein by affinity chromatography. The small amount of VWF:Ag is used to purify factor VIII complex and then removed from the final preparation. The final purified concentrate contains albumin as a stabilizer.[L1053]. The complex was developed by CSL Behring or Baxter Healthcare Corporation and approved in the 90s. Endogenous Factor VIII is essential to the clotting process in the body due to its involvement in the clotting cascade where it is responsible for acting as a co-factor to Factor IX. Activation of Factor IX leads to a cascade of signals that results in activation of Factor X, which then results in the conversion of prothrombin to thrombin, and as a result, leads to the conversion of fibrinogen to fibrin, the fibrous protein that creates the scaffold of the clot. Replacement of Factor VIII is essential for the treatment of Hemophilia A, which is caused by mutations in the Factor VIII gene, leading to a functional deficiency or complete loss of protein. Congenital loss or deficiency of Factor VIII results in the physiologic impairment of the coagulation clotting cascade, and as a result, leads to easy bruising and bleeding. Bleeding can range in severity from minor concerns, such as nosebleeds, to more serious events such as hemorrhaging in the joints, brain, or digestive tract [A32280]. Exogenous replacement of Factor VIII is currently the cornerstone of Hemophilia treatment and is used for the prophylaxis and control of bleeding episodes. Treatment has drastically improved since the 1960s when Factor VIII protein was primarily purified from human plasma, rather than being produced through recombinant DNA technology. Unfortunately, purification of protein from human plasma carries an increased risk of transmission of blood-borne diseases such as HIV and Hepatitis, which in part contributed to the Tainted Blood Scandal in the 1980s and 1990s [A31551, A32272]. Other drug products with similar structure and function to Antihemophilic factor human include [DB13999], which is produced by recombinant DNA technology and is identical in sequence to endogenously produced Factor VIII, but does not contain the B-domain, which has no known biological function and [DB11607], which is a fully recombinant factor VIII-Fc fusion protein which has an extended half-life compared with conventional factor VIII due to conjugation to the dimeric Fc domain of human immunoglobulin G1, a long-lived plasma protein [A31551]. Antihemophilic factor human is approved by the Food and Drug Administration for use in hemophilia A (classical hemophilia) for the prevention and control of hemorrhagic episodes [FDA Label].
DB00025Antihemophilic factor, human recombinantHuman recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
DB00036Coagulation factor VIIa Recombinant HumanRecombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
DB14700Damoctocog alfa pegolIn recent years, various extended half-life factor VIII and factor IX preparations have been studied and gained approval. In order to extend half-lives, techniques such as fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification have been utilized.[A38907] Also known as, BAY94-9027, Damoctocog alfa pegol is a longer-acting Factor VIII therapy formulated with polyethylene glycol (PEG) to reduce the number of infusions necessary to prevent bleeds in patients diagnosed with Haemophilia A.[L4576,A38909,Label] This product has been engineered by Bayer[L4576] and a biological license application has been filed with the FDA in August 2017 and FDA approved in August 2018.[F1609]
DB00035DesmopressinDesmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasma osmolarity or decreased circulating blood volume, ADH mainly acts on the cells of the distal part of the nephron and the collecting tubules in the kidney [T28]. The hormone interacts with V1, V2 or V3 receptors with differing signal cascade systems. Desmopressin displays enhanced antidiuretic potency, fewer pressor effects due to V2-selective actions, and a prolonged half-life and duration of action compared to endogenous ADH [A31661]. It has been employed clinically since 1972 and is available in various formulations including intranasal solution, intravenous solution, oral tablet and oral lyophilisate [A31662]. Desmopressin is indicated for the treatment of polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. It was also newly approved for the treatment of mild classical hemophilia and von Willebrand's disease for minor surgeries. The active ingredient in most formulations is desmopressin acetate. Nocdurna, or desmopressin acetate, was approved by the FDA on June 21st, 2018 for the treatment of nocturia due to nocturnal polyuria in adults. It is available as a sublingual tablet.
DB11607Efmoroctocog alfaEfmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as [DB13999][A31551]. It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It is suitable for all age groups. Haemophilia A is a rare bleeding disorder associated with a slow clotting process caused by the deficiency of factor VIII. Patients with this disorder are more susceptible to recurrent bleeding episodes and excessive bleeding following minor traumatic injuries or surgical procedures [A31551]. Prophylactic treatment may dramatically improve the management of severe haemophilia A in the future by reducing joint bleeding and other hemorrhages that cause chronic pain and disability to patients [A31551, A31552]. Prophylaxis has also shown to reduce the formation of neutralizing anti-FVIII antibodies, or inhibitors [A31552]. Factor VIII is a blood coagulant factor involved in the intrinsic pathway to form fibrin, or a blood clot. Efmoroctocog alfa is a first commercially available rFVIII-Fc fusion protein (rFVIIIFc) where the conjugated molecule of rFVIII to polyethylene glycol is covalently fused to the dimeric Fc domain of human immunoglobulin G1, a long-lived plasma protein [FDA Label]. The B domain of factor VIII is deleted. In animal models of haemophilia, efmoroctocog alfa demonstrated an approximately two-fold longer t½ than commercially available rFVIII products [A31551]. Other drug products with similar structure and function to Efmoroctocog alfa include [DB13999], which is produced by recombinant DNA technology and is identical in sequence to endogenously produced Factor VIII, but does not contain the B-domain, which has no known biological function, and [DB13192], which is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. It is commonly marketed as Elocta or Eloctate for intravenous injection. To date, no confirmed inhibitory autoantibodies were seen in previously treated patients included in clinical studies and treatment-emergent adverse events were generally consistent with those expected in the patient populations being studied [A31551]. The extended half-life of efmoroctocog alfa provides several clinical benefits for patients, including reduced frequency of injections required and improved adherence to prophylaxis [A31551].
DB11330Factor IX Complex (Human)Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra (FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin. Coagulation factors are purified from pooled human plasma and subsequently sterilized and treated. Although Factor IX Complex products contain many different coagulation components, Factor IX is the lead component for potency and efficacy, particularly when used for the treatment of bleeding associated with Hemophilia B (Factor IX deficiency). As the product Kcentra, Factor IX Complex is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients experiencing acute major bleeding or requiring rapid reversal of therapy.
DB13998Lonoctocog alfaNot Available
DB13999Moroctocog alfaMoroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant DNA-based drug with functional characteristics comparable to those of endogenous coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. Moroctocog alfa is identical in sequence to endogenously produced Factor VIII, but does not contain the B-domain, which has no known biological function. Moroctocog alfa is produced through recombinant DNA technology and purification, resulting in a 1438 amino acid, 170 kDa protein [FDA Label]. Clinical evaluation has shown that BDDrFVIII is pharmacokinetically equivalent to full-length recombinant FVIII [A32468, FDA Label]. Also known as Anti-Hemophilic Factor (AHF), endogenous Factor VIII is essential to the clotting process in the body due to its involvement in the clotting cascade where it is responsible for acting as a co-factor to Factor IX. Activation of Factor IX leads to a cascade of signals that results in activation of Factor X, which then results in the conversion of prothrombin to thrombin, and as a result, leads to the conversion of fibrinogen to fibrin, the fibrous protein that creates the scaffold of the clot. Replacement of Factor VIII is essential for the treatment of Hemophilia A, which is caused by mutations in the Factor VIII gene, leading to a functional deficiency or complete loss of protein. Congenital loss or deficiency of Factor VIII results in the physiologic impairment of the coagulation clotting cascade, and as a result, leads to easy bruising and bleeding. Bleeding can range in severity from minor concerns, such as nosebleeds, to more serious events such as hemorrhaging in the joints, brain, or digestive tract [A32280]. Exogenous replacement of Factor VIII is currently the cornerstone of Hemophilia treatment and is used for the prophylaxis and control of bleeding episodes. Treatment has drastically improved since the 1960s when Factor VIII protein was primarily purified from human plasma, rather than being produced through recombinant DNA technology. Unfortunately, purification of protein from human plasma carries an increased risk of transmission of blood-borne diseases such as HIV and Hepatitis, which in part contributed to the Tainted Blood Scandal in the 1980s [A31551, A32272, L2177]. Use of recombinant DNA-derived clotting factor treatments, such as Moroctocog alfa, has reduced this risk. Other drug products with similar structure and function to Moroctocog alfa include [DB13192], which is purified Factor VIII from human pooled blood and contains both A- and B-subunits, and [DB11607], which is a fully recombinant factor VIII-Fc fusion protein which has an extended half-life compared with conventional factor VIII due to conjugation to the dimeric Fc domain of human immunoglobulin G1, a long-lived plasma protein [A31551]. Moroctocog alfa is approved by Health Canada and by the European Medicines Agency for the control and prevention of hemorrhagic episodes and for routine and surgical prophylaxis in patients with hemophilia A (congenital factor VIII deficiency or classic hemophilia). As it does not contain von Willebrand factor it is not indicated in von Willebrand’s disease [FDA Label].
DB09108Simoctocog alfaSimoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the factor VIII in the intrinsic pathway of blood coagulation system. As patients with haemophilia A are predisposed to episodes of recurrent bleeding [L1115], simoctocog alfa can be administered for the treatment or prevention of bleeding such as prior to surgical procedures. Simoctocog alfa is a glycoprotein consisting of 1440 amino acids with an approximate molecular mass of 170 kDa, comprising the FVIII domains A1-A2 + A3-C1-C2 whereas the B-domain, present in the full-length plasma-derived FVIII, has been deleted and replaced by a 16 amino acid linker. Simoctocog alfa is a fourth-generation BDD FVIII product made in the human embryonic kidney (HEK) cell line. Full human post-translational modifications via elimination of potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and longer half-life [A31525]. Simoctocog alfa is marketed in Europe under the trade name Nuwiq for intravenous injection.
DB11606Susoctocog alfaIntravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the activated partial thromboplastin time (aPTT) assay, a conventional in vitro test for biological activity of factor VIII. Patients with AHA have normal Factor VIII genes for coagulation pathways but develop inhibitory autoantibodies directed against Factor VIII. These autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this procoagulant protein. Susoctocog alfa serves to temporarily restore the inhibited endogenous Factor VIII for effective hemostasis. In a global, prospective, controlled, multi-center Phase 2/3 open-label clinical trial, all patients responded to susoctocog alfa treatment within 24 hours [L1129]. Susoctocog alfa is a glycoprotein containing a 90 kDa heavy chain and a 80 kDa light chain with the naturally-occuring B domain replaced with a twenty-four amino acid linker. Susoctocog alfa was approved by the FDA in October 2014 and is marketed under the brand name Obizur for intravenous injection. It is the first recombinant porcine FVIII treatment approved for AHA that allows physicians to manage the treatment's efficacy and safety by measuring factor VIII activity levels in addition to clinical assessments [L1129]. The recombinant porcine sequence allows less susceptibility to inactivation by circulating human factor VIII antibodies.
DB09109Turoctocog alfaTuroctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human- or animal-derived materials. During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid 720, and a monoclonal antibody binding C-terminal to this position is used in the purification process allowing isolation of the intact rFVIII.[A31504] It was developped by Novo Nordisk and FDA approved in October 16, 2013.[L1104]
DB14738Turoctocog alfa pegolTuroctocog alfa pegol is a pegylated version of [turoctocog alfa]. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain [F3685]. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human or animal-derived materials [F3685]. During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid 720, and a monoclonal antibody binding C-terminal to this position is used in the purification process allowing isolation of the intact rFVIII [A31504]. It was developed by Novo Nordisk and approved by the US FDA on October 16, 2013 [L1104]. The essential difference between turoctocog alfa and N8-GP, however, is the specific attachment of a 40-kDa polyethylene glycol (PEG) group to a specific _O_-glycan in the truncated B-domain of the general turoctocog alfa rFVIII structure [A31506, A32069]. This modification to the general turoctocog alfa rFVIII structure makes N8-GP an extended half-life factor VIII molecule for factor VIII replacement therapy in patients with factor VIII deficiency, or hemophilia A [F3649]. As such, turoctocog alfa pegol is a valuable expansion to the drug therapies available for treating hemophilia A as it ultimately provides a less burdensome and more convenient dosing regimen for patients that is less frequent than that for turoctocog alfa.
DrugDrug NameTargetType
DB09329Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factortarget
DB09329Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factorcarrier
DB13192Antihemophilic factor humanCoagulation factor IXtarget
DB13192Antihemophilic factor humanCoagulation factor Xtarget
DB13192Antihemophilic factor humanVitamin K-dependent protein Cenzyme
DB00025Antihemophilic factor, human recombinantCoagulation factor Xtarget
DB00025Antihemophilic factor, human recombinantPhytanoyl-CoA dioxygenase, peroxisomaltarget
DB00025Antihemophilic factor, human recombinantCoagulation factor IXtarget
DB00025Antihemophilic factor, human recombinantAsialoglycoprotein receptor 2target
DB00025Antihemophilic factor, human recombinant78 kDa glucose-regulated proteintarget
DB00025Antihemophilic factor, human recombinantCalreticulintarget
DB00025Antihemophilic factor, human recombinantCalnexintarget
DB00025Antihemophilic factor, human recombinantProtein ERGIC-53target
DB00025Antihemophilic factor, human recombinantProlow-density lipoprotein receptor-related protein 1target
DB00025Antihemophilic factor, human recombinantMultiple coagulation factor deficiency protein 2target
DB00025Antihemophilic factor, human recombinantvon Willebrand factortarget
DB00025Antihemophilic factor, human recombinantProthrombinenzyme
DB00025Antihemophilic factor, human recombinantVitamin K-dependent protein Cenzyme
DB00036Coagulation factor VIIa Recombinant HumanCoagulation factor Xtarget
DB00036Coagulation factor VIIa Recombinant HumanTissue factortarget
DB00036Coagulation factor VIIa Recombinant HumanSerine protease hepsintarget
DB00036Coagulation factor VIIa Recombinant HumanTissue factor pathway inhibitortarget
DB00036Coagulation factor VIIa Recombinant HumanVitamin K-dependent gamma-carboxylasetarget
DB00036Coagulation factor VIIa Recombinant HumanCoagulation factor VIItarget
DB14700Damoctocog alfa pegolCoagulation factor VIIItarget
DB00035DesmopressinVasopressin V1a receptortarget
DB00035DesmopressinVasopressin V1b receptortarget
DB00035DesmopressinVasopressin V2 receptortarget
DB00035DesmopressinProstaglandin G/H synthase 1enzyme
DB00035DesmopressinProstaglandin G/H synthase 2enzyme
DB11607Efmoroctocog alfavon Willebrand factortarget
DB13998Lonoctocog alfaCoagulation factor Xtarget
DB13998Lonoctocog alfaPhytanoyl-CoA dioxygenase, peroxisomaltarget
DB13998Lonoctocog alfaCoagulation factor IXtarget
DB13998Lonoctocog alfaAsialoglycoprotein receptor 2target
DB13998Lonoctocog alfa78 kDa glucose-regulated proteintarget
DB13998Lonoctocog alfaCalreticulintarget
DB13998Lonoctocog alfaCalnexintarget
DB13998Lonoctocog alfaProtein ERGIC-53target
DB13998Lonoctocog alfaProlow-density lipoprotein receptor-related protein 1target
DB13998Lonoctocog alfaMultiple coagulation factor deficiency protein 2target
DB13998Lonoctocog alfavon Willebrand factortarget
DB13998Lonoctocog alfaProthrombinenzyme
DB13998Lonoctocog alfaVitamin K-dependent protein Cenzyme
DB13999Moroctocog alfaCoagulation factor Xtarget
DB13999Moroctocog alfaPhytanoyl-CoA dioxygenase, peroxisomaltarget
DB13999Moroctocog alfaCoagulation factor IXtarget
DB13999Moroctocog alfaAsialoglycoprotein receptor 2target
DB13999Moroctocog alfa78 kDa glucose-regulated proteintarget
DB13999Moroctocog alfaCalreticulintarget
DB13999Moroctocog alfaCalnexintarget
DB13999Moroctocog alfaProtein ERGIC-53target
DB13999Moroctocog alfaProlow-density lipoprotein receptor-related protein 1target
DB13999Moroctocog alfaMultiple coagulation factor deficiency protein 2target
DB13999Moroctocog alfavon Willebrand factortarget
DB13999Moroctocog alfaProthrombinenzyme
DB13999Moroctocog alfaVitamin K-dependent protein Cenzyme
DB09108Simoctocog alfavon Willebrand factortarget
DB11606Susoctocog alfavon Willebrand factortarget
DB09109Turoctocog alfaCoagulation factor IXtarget
DB09109Turoctocog alfaCoagulation factor Xtarget
DB09109Turoctocog alfaProthrombintarget
DB14738Turoctocog alfa pegolVitamin K-dependent protein Cenzyme
DB14738Turoctocog alfa pegolCoagulation factor Xenzyme
DB14738Turoctocog alfa pegolCoagulation factor IXtarget
DB14738Turoctocog alfa pegolCoagulation factor Xtarget
DB14738Turoctocog alfa pegolProthrombintarget
DB14738Turoctocog alfa pegolvon Willebrand factorcarrier
DrugDrug NamePhaseStatusCount
DB09329Antihemophilic Factor (Recombinant), PEGylated1Completed1
DB00025Antihemophilic factor, human recombinant1Completed9
DB00025Antihemophilic factor, human recombinant1Not Yet Recruiting1
DB00036Coagulation factor VIIa Recombinant Human1Completed1
DB00036Coagulation factor VIIa Recombinant Human1Withdrawn1
DB12820Concizumab1Completed1
DB14700Damoctocog alfa pegol1Not Yet Recruiting1
DB00035Desmopressin1Completed1
DB13923Emicizumab1Completed1
DB11661Eptacog alfa pegol (activated)1Completed2
DB15002Fitusiran1Completed1
DB15278Marzeptacog alfa (activated)1Completed1
DB09109Turoctocog alfa1Completed5
DB14738Turoctocog alfa pegol1Completed3
DB00495Zidovudine1Completed1
DB15002Fitusiran1 / 2Active Not Recruiting1
DB00025Antihemophilic factor, human recombinant2Completed1
DB05016Ataluren2Terminated1
DB00036Coagulation factor VIIa Recombinant Human2Completed1
DB12820Concizumab2Active Not Recruiting1
DB00038Oprelvekin2Completed1
DB00073Rituximab2Completed1
DB09109Turoctocog alfa2Active Not Recruiting1
DB12409Vatreptacog alfa2Completed1
DB00025Antihemophilic factor, human recombinant2 / 3Completed2
DB00635Prednisone2 / 3Terminated1
DB00073Rituximab2 / 3Terminated1
DB13151Anti-inhibitor coagulant complex3Completed1
DB13151Anti-inhibitor coagulant complex3Recruiting1
DB09329Antihemophilic Factor (Recombinant), PEGylated3Completed2
DB09329Antihemophilic Factor (Recombinant), PEGylated3Recruiting1
DB13192Antihemophilic factor human3Completed3
DB00025Antihemophilic factor, human recombinant3Completed8
DB00025Antihemophilic factor, human recombinant3Recruiting1
DB00025Antihemophilic factor, human recombinant3Terminated2
DB00036Coagulation factor VIIa Recombinant Human3Active Not Recruiting1
DB00036Coagulation factor VIIa Recombinant Human3Completed1
DB11607Efmoroctocog alfa3Completed2
DB13923Emicizumab3Active Not Recruiting6
DB11330Factor IX Complex (Human)3Active Not Recruiting1
DB15002Fitusiran3Recruiting3
DB11606Susoctocog alfa3Recruiting1
DB09034Suvorexant3Recruiting1
DB09109Turoctocog alfa3Completed6
DB14738Turoctocog alfa pegol3Active Not Recruiting1
DB14738Turoctocog alfa pegol3Completed3
DB14738Turoctocog alfa pegol3Enrolling by Invitation1
DB13192Antihemophilic factor human4Completed1
DB13192Antihemophilic factor human4Recruiting1
DB00025Antihemophilic factor, human recombinant4Completed9
DB00025Antihemophilic factor, human recombinant4Recruiting1
DB00025Antihemophilic factor, human recombinant4Terminated2
DB00025Antihemophilic factor, human recombinant4Withdrawn1
DB00036Coagulation factor VIIa Recombinant Human4Completed1
DB00900Didanosine4Completed1
DB11607Efmoroctocog alfa4Active Not Recruiting1
DB11607Efmoroctocog alfa4Recruiting1
DB13923Emicizumab4Recruiting1
DB11330Factor IX Complex (Human)4Completed1
DB00224Indinavir4Completed1
DB00709Lamivudine4Completed1
DB00649Stavudine4Completed1
DB09109Turoctocog alfa4Completed1
DB00943Zalcitabine4Completed1
DB00495Zidovudine4Completed1
DB09329Antihemophilic Factor (Recombinant), PEGylatedNot AvailableRecruiting2
DB13192Antihemophilic factor humanNot AvailableRecruiting1
DB00025Antihemophilic factor, human recombinantNot AvailableCompleted15
DB00025Antihemophilic factor, human recombinantNot AvailableRecruiting6
DB00025Antihemophilic factor, human recombinantNot AvailableUnknown Status2
DB14473Beroctocog alfaNot AvailableActive Not Recruiting1
DB14473Beroctocog alfaNot AvailableCompleted1
DB00100Coagulation Factor IX (Recombinant)Not AvailableCompleted1
DB00036Coagulation factor VIIa Recombinant HumanNot AvailableCompleted1
DB14700Damoctocog alfa pegolNot AvailableNot Yet Recruiting1
DB11607Efmoroctocog alfaNot AvailableActive Not Recruiting1
DB11607Efmoroctocog alfaNot AvailableTerminated1
DB11608Eftrenonacog alfaNot AvailableRecruiting1
DB11608Eftrenonacog alfaNot AvailableTerminated1
DB13923EmicizumabNot AvailableAvailable1
DB01050IbuprofenNot AvailableCompleted1
DB13999Moroctocog alfaNot AvailableNot Yet Recruiting1
DB00302Tranexamic acidNot AvailableCompleted1
DB09109Turoctocog alfaNot AvailableActive Not Recruiting1
DB09109Turoctocog alfaNot AvailableEnrolling by Invitation2
DB00495ZidovudineNot AvailableCompleted1