Toothache

Also known as: Odontalgia / Toothaches / Dentagra / Enlargement of alveolar ridge NOS / Tooth ache / Tooth pain

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain symptoms due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots and myocardial infarction (MI) [FDA label]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, buffered tablets, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers and infants [FDA label].
DB00788NaproxenAn anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidSerum albumincarrier
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidSolute carrier family 22 member 7transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C8enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidNuclear factor NF-kappa-Btarget
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenMultidrug resistance protein 1transporter
DrugDrug NamePhaseStatusCount
DB00316Acetaminophen2Terminated1
DB00825Levomenthol2Terminated1
DB00497Oxycodone2Terminated1
DB11079Trolamine salicylate2Terminated1
DB00788Naproxen3Completed1
DB00316Acetaminophen4Completed1
DB01086Benzocaine4Completed1
DB00297Bupivacaine4Completed1
DB00668Epinephrine4Completed1
DB11823Esketamine4Completed1
DB00813Fentanyl4Completed1
DB00956Hydrocodone4Completed1
DB00316AcetaminophenNot AvailableWithdrawn1
DB00956HydrocodoneNot AvailableWithdrawn1
DB01050IbuprofenNot AvailableWithdrawn1
DB00788NaproxenNot AvailableCompleted1
DB00788NaproxenNot AvailableWithdrawn1