Fibromyalgia

Also known as: Fibromyalgias / Fibromyositis / Fibrositis / Muscular rheumatism / Fibromyalgia syndrome

DrugDrug NameDrug Description
DB00476DuloxetineDuloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686.[A178741] Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder.[L6454] It has since received approval for a variety of indications including the treatment of neuropathic pain, Generalized Anxiety disorder, osteoarthritis, and stress incontinence. Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.
DB04896MilnacipranMilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of treating fibromyalgia [F3925], although other regional regulatory authorities like the EMA, among others, have not yet approved the agent for such treatment, citing lack of robust evidence of efficacy, insufficient demonstration of maintenance of effect, and other concerns [F3928, F3934]. Nevertheless, milnacipran demonstrates a somewhat unique characteristic among SNRIs to elicit a relatively balanced reuptake inhibition of both serotonin and noradrenaline, with a somewhat increased preference for noradrenaline reuptake inhibition - which is potentially a point of interest given the plausible proposal that noradrenaline plays an important role in the mitigation of pain signals in the descending inhibitory pain pathways in the brain and spinal cord [A175759, A175843, A175846]. Moreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), which has investigationally been associated with β-amyloid plaque formation - making the agent a possible course of treatment for Alzheimer's disease [A175957].
DB00370MirtazapineMirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994.[A177946] This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy.[A178144,L6160] In addition to its beneficial effects in depression, mirtazapine has been reported to be efficacious in the off-label management of various other conditions. It may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.[A177811]
DB00230PregabalinPregabalin is an anticonvulsant drug used for neuropathic pain, epilepsy and generalized anxiety disorder.[A31161] Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin achieves antihyperalgesic activity by binding to the α2δ subunit of the voltage-dependent calcium channels [A31162]. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[L1006][FDA Label] It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders [A31161].
DrugDrug NamePhaseStatusCount
DB00741Hydrocortisone0Completed1
DB00318Codeine1Completed1
DB00668Epinephrine1Completed1
DB12395Esreboxetine1Completed1
DB00281Lidocaine1Completed1
DB04896Milnacipran1Completed1
DB00218Moxifloxacin1Completed1
DB00715Paroxetine1Completed1
DB00321Amitriptyline1 / 2Completed1
DB00715Paroxetine1 / 2Completed1
DB00285Venlafaxine1 / 2Completed1
DB00321Amitriptyline2Completed1
DB12768BCG vaccine2Not Yet Recruiting1
DB00190Carbidopa2Completed1
DB00514Dextromethorphan2Recruiting1
DB06262Droxidopa2Completed1
DB12177Eplivanserin2Completed1
DB09119Eslicarbazepine acetate2Completed1
DB12395Esreboxetine2Completed1
DB08917Ferric carboxymaltose2Completed1
DB00472Fluoxetine2Completed1
DB00828Fosfomycin2Completed1
DB00331Metformin2Completed1
DB00486Nabilone2Completed1
DB00413Pramipexole2Terminated1
DB00230Pregabalin2Terminated1
DB00230Pregabalin2Unknown Status1
DB00545Pyridostigmine2Completed1
DB12143Rezatomidine2Terminated1
DB09153Sodium chloride2Completed1
DB09153Sodium chloride2Not Yet Recruiting1
DB09072Sodium oxybate2Completed1
DB00193Tramadol2Completed1
DB00321Amitriptyline2 / 3Unknown Status1
DB00996Gabapentin2 / 3Completed1
DB01065Melatonin2 / 3Unknown Status1
DB04896Milnacipran2 / 3Completed1
DB00230Pregabalin2 / 3Completed1
DB00757Dolasetron3Completed1
DB00476Duloxetine3Completed8
DB00476Duloxetine3Recruiting1
DB00668Epinephrine3Unknown Status1
DB01175Escitalopram3Recruiting1
DB12395Esreboxetine3Withdrawn1
DB00472Fluoxetine3Completed1
DB00996Gabapentin3Completed1
DB00920Ketotifen3Completed1
DB00125L-Arginine3Completed1
DB00281Lidocaine3Unknown Status1
DB01043Memantine3Unknown Status1
DB04896Milnacipran3Completed4
DB04896Milnacipran3Terminated2
DB11825Mirogabalin3Completed1
DB00230Pregabalin3Completed14
DB00230Pregabalin3Recruiting1
DB00545Pyridostigmine3Enrolling by Invitation1
DB09072Sodium oxybate3Completed4
DB00052Somatotropin3Completed1
DB00193Tramadol3Completed1
DB00316Acetaminophen4Completed1
DB00321Amitriptyline4Completed2
DB00924Cyclobenzaprine4Unknown Status1
DB00476Duloxetine4Completed1
DB00476Duloxetine4Terminated1
DB00476Duloxetine4Withdrawn1
DB00402Eszopiclone4Completed1
DB01628Etoricoxib4Unknown Status1
DB04896Milnacipran4Completed6
DB04896Milnacipran4Unknown Status1
DB04896Milnacipran4Withdrawn1
DB00704Naltrexone4Recruiting1
DB00230Pregabalin4Completed5
DB00230Pregabalin4Withdrawn1
DB01224Quetiapine4Completed3
DB00017Salmon Calcitonin4Withdrawn1
DB09034Suvorexant4Terminated1
DB00193Tramadol4Completed1
DB00656Trazodone4Completed1
DB00909Zonisamide4Withdrawn1
DB00316AcetaminophenNot AvailableCompleted1
DB06594AgomelatineNot AvailableCompleted1
DB00321AmitriptylineNot AvailableCompleted1
DB06634CasopitantNot AvailableCompleted1
DB00215CitalopramNot AvailableUnknown Status1
DB00470DronabinolNot AvailableUnknown Status1
DB00476DuloxetineNot AvailableNo Longer Available1
DB00476DuloxetineNot AvailableNot Yet Recruiting1
DB00476DuloxetineNot AvailableUnknown Status2
DB00668EpinephrineNot AvailableCompleted1
DB00996GabapentinNot AvailableCompleted1
DB01202LevetiracetamNot AvailableCompleted1
DB00281LidocaineNot AvailableCompleted1
DB00279LiothyronineNot AvailableCompleted1
DB14009Medical CannabisNot AvailableRecruiting1
DB00603Medroxyprogesterone acetateNot AvailableTerminated1
DB00486NabiloneNot AvailableCompleted1
DB00704NaltrexoneNot AvailableCompleted1
DB00704NaltrexoneNot AvailableUnknown Status1
DB00704NaltrexoneNot AvailableWithdrawn1
DB00230PregabalinNot AvailableCompleted1
DB00230PregabalinNot AvailableNot Yet Recruiting1
DB00230PregabalinNot AvailableRecruiting2
DB00230PregabalinNot AvailableUnknown Status1
DB00135TyrosineNot AvailableTerminated1