Cluster Headache

Also known as: Cluster headaches / Cluster headache / Headaches, Cluster / Ciliary neuralgia / Headache histamine / Horton's headache / Headache vasomotor / Migrainous neuralgia / Headaches cluster

DrugDrug NameDrug Description
DB00320DihydroergotamineA 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders.
DB00696ErgotamineA vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
DB00273TopiramateTopiramate (brand name Topamax) is an anticonvulsant drug produced by Ortho-McNeil Neurologics, a division of Johnson & Johnson. It is used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved for, and now most frequently prescribed for, the prevention of migraines. [Wikipedia]. A combination product containing phentermine and topiramate extended-release called QSYMIA® is indicated for the management of obesity. On August 2013, an extended released formulation, marketed as Trokendi XR has been approved for the management of partial onset, tonic-clonic, and Lennox-Gastaut Syndrome seizures.
DrugDrug NameTargetType
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DB00320DihydroergotamineCytochrome P450 3A4enzyme
DB00320DihydroergotamineAlpha-2A adrenergic receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DB00320DihydroergotamineMultidrug resistance protein 1transporter
DB00696ErgotamineAlpha-1A adrenergic receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Dtarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Btarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Atarget
DB00696ErgotamineAlpha-2A adrenergic receptortarget
DB00696ErgotamineD(2) dopamine receptortarget
DB00696ErgotamineAlpha-2B adrenergic receptortarget
DB00696ErgotamineSodium-dependent noradrenaline transportertarget
DB00696ErgotamineCytochrome P450 3A4enzyme
DB00696ErgotamineAlpha-1B adrenergic receptortarget
DB00696ErgotamineAlpha-1D adrenergic receptortarget
DB00696ErgotamineMultidrug resistance protein 1transporter
DB00696ErgotamineD(1) dopamine receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Atarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Ftarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Ctarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Btarget
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateSodium channel protein type 1 subunit alphatarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateGlutamate receptor ionotropic, kainate 1target
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateGABA-A receptor (anion channel)target
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DrugDrug NamePhaseStatusCount
DB06774Capsaicin1Active Not Recruiting1
DB09140Oxygen1Unknown Status1
DB11664Psilocybine1Recruiting1
DB00669Sumatriptan1Completed1
DB00083Botulinum Toxin Type A1 / 2Completed1
DB00083Botulinum Toxin Type A1 / 2Recruiting1
DB00796Candesartan cilexetil2Completed1
DB09157Carbon dioxide2Terminated1
DB00661Verapamil2 / 3Completed1
DB14041Fremanezumab3Enrolling by Invitation1
DB09072Sodium oxybate3Not Yet Recruiting1
DB00669Sumatriptan3Completed1
DB00273Topiramate4Terminated1
DB00315Zolmitriptan4Not Yet Recruiting1
DB06379Calcitonin gene-related peptideNot AvailableActive Not Recruiting1
DB00313Valproic AcidNot AvailableCompleted1