Delirium

Also known as: [X]Delirium, unspecified / Delirious / Acute brain syndrome / Brain syndrome acute / Syndrome brain acute / Acute delirium / Confusion NOS / Deliria

DrugDrug NameDrug Description
DB00450DroperidolA butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
DB00502HaloperidolA phenyl-piperidinyl-butyrophenone, traditional antipsychotic drug that is used primarily to treat schizophrenia and other psychoses. It is also used for the management of schizoaffective disorder, delusional disorders, ballism, and Tourette syndrome (a drug of choice) and occasionally as adjunctive therapy in mental retardation and the chorea associated with Huntington's disease. It is a potent antiemetic and is used in the treatment of intractable hiccups [L1994], [L1996]. The efficacy of haloperidol was first established in controlled trials in the 1960s [L2014]. Interestingly, in vivo pharmacogenetic studies have demonstrated that the metabolism of haloperidol may be modulated by genetically determined polymorphic _CYP2D6_ activity. However, these findings contradict the findings from studies in vitro with human liver microsomes and from drug interaction studies in vivo. Inter-ethnic and pharmacogenetic differences in haloperidol metabolism may possibly explain these observations [A32346].
DB00186LorazepamLorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.[A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095]
DB00334OlanzapineOlanzapine is an atypical antipsychotic, approved by the FDA in 1996. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company, whose patent for olanzapine proper ends in 2011.
DrugDrug NameTargetType
DB00450DroperidolD(2) dopamine receptortarget
DB00450DroperidolAlpha-1A adrenergic receptortarget
DB00502HaloperidolD(2) dopamine receptortarget
DB00502HaloperidolGlutamate receptor ionotropic, NMDA 2Btarget
DB00502HaloperidolD(1A) dopamine receptortarget
DB00502HaloperidolCytochrome P450 1A2enzyme
DB00502HaloperidolCytochrome P450 2D6enzyme
DB00502Haloperidol5-hydroxytryptamine receptor 2Atarget
DB00502HaloperidolD(3) dopamine receptortarget
DB00502HaloperidolCytochrome P450 3A4enzyme
DB00502HaloperidolCytochrome P450 3A5enzyme
DB00502HaloperidolCytochrome P450 3A7enzyme
DB00502HaloperidolMultidrug resistance protein 1transporter
DB00502HaloperidolCarbonyl reductase [NADPH] 1enzyme
DB00502HaloperidolUDP-glucuronosyltransferase 1-9enzyme
DB00502HaloperidolCytochrome P450 1A1enzyme
DB00502HaloperidolCytochrome P450 2C19enzyme
DB00502HaloperidolCytochrome P450 2C9enzyme
DB00502HaloperidolMelanin-concentrating hormone receptor 1target
DB00502HaloperidolSynaptic vesicular amine transportertarget
DB00186LorazepamTranslocator proteintarget
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA-A receptor (anion channel)target
DB00186LorazepamCytochrome P450 3A4enzyme
DB00334OlanzapineMuscarinic acetylcholine receptor M5target
DB00334OlanzapineD(1A) dopamine receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineD(4) dopamine receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineD(2) dopamine receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineD(3) dopamine receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 1Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 1Btarget
DB00334Olanzapine5-hydroxytryptamine receptor 1Dtarget
DB00334Olanzapine5-hydroxytryptamine receptor 1Etarget
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334Olanzapine5-hydroxytryptamine receptor 7target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineAlpha-2A adrenergic receptortarget
DB00334OlanzapineAlpha-2B adrenergic receptortarget
DB00334OlanzapineAlpha-2C adrenergic receptortarget
DB00334OlanzapineD(1B) dopamine receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineMultidrug resistance protein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 2Btarget
DB00334Olanzapine5-hydroxytryptamine receptor 5Atarget
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineHistamine H2 receptortarget
DB00334OlanzapineHistamine H4 receptortarget
DB00334OlanzapineGABA-A receptor (anion channel)target
DB00334OlanzapineBeta adrenergic receptortarget
DB00334OlanzapineD(2L) dopamine receptortarget
DB00334OlanzapineD(2S) dopamine receptortarget
DB00334OlanzapineUDP-glucuronosyltransferase 1-1enzyme
DrugDrug NamePhaseStatusCount
DB01224Quetiapine1 / 2Terminated1
DB11121Chloroxylenol2Enrolling by Invitation1
DB00575Clonidine2Terminated1
DB00633Dexmedetomidine2Completed2
DB00633Dexmedetomidine2Recruiting2
DB00633Dexmedetomidine2Unknown Status1
DB00633Dexmedetomidine2Withdrawn1
DB00843Donepezil2Completed1
DB00813Fentanyl2Recruiting1
DB00502Haloperidol2Completed3
DB00186Lorazepam2Completed1
DB01065Melatonin2Recruiting1
DB14158Microcrystalline cellulose2Recruiting1
DB00683Midazolam2Withdrawn1
DB00980Ramelteon2Recruiting1
DB00140Riboflavin2Recruiting1
DB00296Ropivacaine2Recruiting1
DB01236Sevoflurane2Completed1
DB09153Sodium Chloride2Recruiting1
DB00152Thiamine2Enrolling by Invitation1
DB09315Xenon-1332Completed1
DB00246Ziprasidone2Completed1
DB00633Dexmedetomidine2 / 3Completed1
DB00502Haloperidol2 / 3Not Yet Recruiting1
DB00186Lorazepam2 / 3Not Yet Recruiting1
DB01224Quetiapine2 / 3Not Yet Recruiting1
DB00575Clonidine3Not Yet Recruiting1
DB00633Dexmedetomidine3Recruiting2
DB00633Dexmedetomidine3Terminated2
DB00633Dexmedetomidine3Withdrawn1
DB00843Donepezil3Completed1
DB00502Haloperidol3Active Not Recruiting1
DB00502Haloperidol3Completed1
DB00502Haloperidol3Recruiting1
DB00502Haloperidol3Terminated4
DB01221Ketamine3Completed1
DB01065Melatonin3Recruiting1
DB01065Melatonin3Terminated1
DB00422Methylphenidate3Terminated1
DB00745Modafinil3Withdrawn1
DB00230Pregabalin3Completed1
DB00818Propofol3Recruiting1
DB01224Quetiapine3Completed1
DB01224Quetiapine3Terminated1
DB01224Quetiapine3Unknown Status1
DB00989Rivastigmine3Completed1
DB00989Rivastigmine3Terminated1
DB09153Sodium Chloride3Not Yet Recruiting1
DB09153Sodium Chloride3Terminated1
DB00246Ziprasidone3Active Not Recruiting1
DB00315Zolmitriptan3Recruiting1
DB00316Acetaminophen4Active Not Recruiting1
DB00915Amantadine4Unknown Status1
DB12537Benzodiazepine4Withdrawn1
DB11121Chloroxylenol4Completed1
DB12153Citicoline4Withdrawn1
DB00575Clonidine4Completed1
DB01189Desflurane4Recruiting1
DB01234Dexamethasone4Recruiting2
DB00633Dexmedetomidine4Active Not Recruiting1
DB00633Dexmedetomidine4Completed8
DB00633Dexmedetomidine4Enrolling by Invitation1
DB00633Dexmedetomidine4Not Yet Recruiting3
DB00633Dexmedetomidine4Recruiting3
DB00633Dexmedetomidine4Unknown Status3
DB00633Dexmedetomidine4Withdrawn1
DB00843Donepezil4Completed2
DB00584Enalapril4Recruiting1
DB00292Etomidate4Not Yet Recruiting1
DB00813Fentanyl4Enrolling by Invitation1
DB00813Fentanyl4Recruiting1
DB00813Fentanyl4Unknown Status2
DB00813Fentanyl4Withdrawn1
DB01205Flumazenil4Recruiting1
DB00502Haloperidol4Completed3
DB00502Haloperidol4Recruiting3
DB00753Isoflurane4Recruiting1
DB01221Ketamine4Recruiting1
DB01065Melatonin4Not Yet Recruiting1
DB01065Melatonin4Recruiting1
DB01065Melatonin4Withdrawn1
DB01043Memantine4Terminated1
DB00333Methadone4Unknown Status1
DB00683Midazolam4Completed1
DB00683Midazolam4Enrolling by Invitation1
DB00683Midazolam4Unknown Status2
DB00683Midazolam4Withdrawn1
DB00295Morphine4Completed1
DB00184Nicotine4Completed1
DB00818Propofol4Active Not Recruiting1
DB00818Propofol4Completed2
DB00818Propofol4Enrolling by Invitation1
DB00818Propofol4Not Yet Recruiting3
DB00818Propofol4Recruiting3
DB00818Propofol4Unknown Status2
DB00818Propofol4Withdrawn1
DB00980Ramelteon4Recruiting1
DB00980Ramelteon4Withdrawn1
DB00899Remifentanil4Unknown Status1
DB00734Risperidone4Terminated1
DB00734Risperidone4Unknown Status1
DB00989Rivastigmine4Completed2
DB00989Rivastigmine4Terminated1
DB00296Ropivacaine4Active Not Recruiting1
DB01236Sevoflurane4Completed1
DB01236Sevoflurane4Not Yet Recruiting1
DB01236Sevoflurane4Recruiting3
DB09153Sodium Chloride4Completed3
DB09153Sodium Chloride4Recruiting1
DB00656Trazodone4Terminated1
DB00246Ziprasidone4Withdrawn1
DB00425Zolpidem4Terminated1
DB01076AtorvastatinNot AvailableCompleted1
DB11121ChloroxylenolNot AvailableRecruiting1
DB01189DesfluraneNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableActive Not Recruiting2
DB00633DexmedetomidineNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableRecruiting2
DB00514DextromethorphanNot AvailableRecruiting1
DB00502HaloperidolNot AvailableCompleted2
DB00502HaloperidolNot AvailableTerminated1
DB00030Insulin HumanNot AvailableNot Yet Recruiting2
DB01221KetamineNot AvailableActive Not Recruiting1
DB01221KetamineNot AvailableRecruiting1
DB01065MelatoninNot AvailableCompleted1
DB00334OlanzapineNot AvailableCompleted2
DB00334OlanzapineNot AvailableTerminated1
DB00818PropofolNot AvailableCompleted3
DB00818PropofolNot AvailableRecruiting3
DB01224QuetiapineNot AvailableCompleted1
DB00980RamelteonNot AvailableEnrolling by Invitation1
DB00899RemifentanilNot AvailableRecruiting1
DB01236SevofluraneNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableActive Not Recruiting1
DB06206SugammadexNot AvailableRecruiting1