Vitiligo
all indicationsAlso known as: VITILIGO
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB00337 | Pimecrolimus | Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis (eczema). It is currently available as a topical cream, once marketed by Novartis, (however Galderma will be promoting the molecule in Canada in early 2007) under the trade name Elidel. [Wikipedia] |
| DB00864 | Tacrolimus | Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. |
| Drug | Drug Name | Phase | Status | Count |
|---|---|---|---|---|
| DB01281 | Abatacept | 1 | Recruiting | 1 |
| DB04931 | Afamelanotide | 1 | Completed | 1 |
| DB04931 | Afamelanotide | 2 | Completed | 1 |
| DB05676 | Apremilast | 2 | Recruiting | 2 |
| DB01076 | Atorvastatin | 2 | Active Not Recruiting | 1 |
| DB00005 | Etanercept | 2 | Completed | 1 |
| DB08877 | Ruxolitinib | 2 | Recruiting | 1 |
| DB00641 | Simvastatin | 2 | Completed | 1 |
| DB00620 | Triamcinolone | 2 | Recruiting | 1 |
| DB00864 | Tacrolimus | 2 / 3 | Terminated | 1 |
| DB00620 | Triamcinolone | 2 / 3 | Recruiting | 1 |
| DB00864 | Tacrolimus | 3 | Recruiting | 1 |
| DB00316 | Acetaminophen | 4 | Unknown Status | 1 |
| DB00905 | Bimatoprost | 4 | Withdrawn | 1 |
| DB01114 | Chlorphenamine | 4 | Unknown Status | 1 |
| DB00514 | Dextromethorphan | 4 | Unknown Status | 1 |
| DB00764 | Mometasone | 4 | Unknown Status | 1 |
| DB00388 | Phenylephrine | 4 | Unknown Status | 1 |
| DB00337 | Pimecrolimus | 4 | Unknown Status | 1 |
| DB00864 | Tacrolimus | 4 | Unknown Status | 2 |
| DB01632 | Alpha-Phosphoribosylpyrophosphoric Acid | Not Available | Not Yet Recruiting | 1 |
| DB00588 | Fluticasone propionate | Not Available | Withdrawn | 1 |