Anovulatory cycle

Also known as: Anovulation / Anovulatory / Anovulations / Ovulation failure / Anovular cycles

DrugDrug NameDrug Description
DB01006LetrozoleLetrozole (INN, trade name Femara®) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letrozole blocks the production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit. It is important to note that letrozole does not decrease the production of mineralocorticoids or corticosteroids. In contrast, the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production. Side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis, which is why prescriptions of Letrozole are often accompanied by prescriptions of osteoporosis-fighting medication such as Fosamax. Letrozole has shown to reduce estrogen levels by 98 percent while raising testosterone levels. The anti-estrogen action of letrozole is preferred by athletes and bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids. Usage above 2.5 mg/day is known to potentially temporarily kill sex drive. Above 5mg/day for extended periods may cause kidney problems. Letrozole has also been shown to delay the fusing of the growth plates in adolescents. This may boost the effectiveness of growth hormone, and thus Letrozole is used to treat adolescents and children with short stature.
DrugDrug NamePhaseStatusCount
DB01211Clarithromycin1Completed1
DB00882Clomifene1Completed1
DB00715Paroxetine1Completed1
DB01217Anastrozole2Completed1
DB09126Chorionic Gonadotropin (Human)2Not Yet Recruiting1
DB00882Clomifene2Completed2
DB00882Clomifene2Not Yet Recruiting1
DB01006Letrozole2Not Yet Recruiting1
DB09126Chorionic Gonadotropin (Human)3Completed1
DB00882Clomifene3Completed2
DB09024Follitropin3Completed4
DB00331Metformin3Completed1
DB00094Urofollitropin3Completed1
DB00169Cholecalciferol4Completed1
DB00882Clomifene4Completed2
DB00882Clomifene4Recruiting1
DB00783Estradiol4Recruiting1
DB00158Folic Acid4Completed1
DB01006Letrozole4Recruiting1
DB00032Menotropins4Completed1
DB00331Metformin4Active Not Recruiting1
DB00331Metformin4Completed1
DB00882ClomifeneNot AvailableCompleted2
DB00066FollitropinNot AvailableCompleted1
DB00393NimodipineNot AvailableCompleted1