Mycobacterium avium complex infection

Also known as: Mycobacterium avium complex / MAC / Mycobacterium Avium Complex (MAC) / Mycobacterium test / Mycobacteria test / MAC complex / Mycobacterium avium-intracellulare Infection / Mycobacterium avium intracellulare infection / Infection mycobacterium avium / Mycobacterium avium intracellulare

DrugDrug NameDrug Description
DB00479AmikacinAmikacin is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. Similar to other aminoglycosides, amikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin. Amikacin is also nephrotoxic and ototoxic.
DB00207AzithromycinAzithromycin is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides.
DB00330EthambutolAn antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
DB00615RifabutinA broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]
DB01082StreptomycinStreptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis. It is bactericidal due to effects that are not fully understood.
DrugDrug NamePhaseStatusCount
DB00126Ascorbic acid1Completed1
DB00158Folic Acid1Completed1
DB09325Sodium fluoride1Completed1
DB00162Vitamin A1Completed1
DB00163Vitamin E1Completed1
DB00207Azithromycin2 / 3Not Yet Recruiting1
DB00330Ethambutol2 / 3Not Yet Recruiting1
DB01045Rifampicin2 / 3Not Yet Recruiting1
DB00207Azithromycin4Unknown Status2
DB01211Clarithromycin4Unknown Status1
DB00615Rifabutin4Unknown Status1