Narcolepsy

Also known as: Narcolepsy NOS

DrugDrug NameDrug Description
DB00182AmphetamineA CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
DB06413ArmodafinilA stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder.
DB01576DextroamphetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
DB01577MetamfetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
DB00422MethylphenidateA stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD).
DB00745ModafinilA stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder.
DB11642PitolisantAn antagonist and inverse agonist at the histamine H3 receptor that is used to treat narcolepsy in adults.
DB09072Sodium oxybateA central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy.
DB14754SolriamfetolSolriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744].
DrugDrug NameTargetType
DB00182AmphetamineSodium-dependent dopamine transportertarget
DB00182AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
DB00182AmphetamineTrace amine-associated receptor 1target
DB00182AmphetamineCytochrome P450 2D6enzyme
DB00182AmphetamineSolute carrier family 22 member 3transporter
DB00182AmphetamineSolute carrier family 22 member 5transporter
DB00182AmphetamineSynaptic vesicular amine transportertarget
DB00182AmphetamineCytochrome P450 2A6enzyme
DB00182AmphetamineSodium-dependent noradrenaline transportertarget
DB00182AmphetamineAlpha adrenergic receptortarget
DB00182AmphetamineBeta adrenergic receptortarget
DB00182AmphetamineDopamine D2 receptortarget
DB00182AmphetamineAmine oxidase [flavin-containing] Btarget
DB00182AmphetamineSodium-dependent serotonin transportertarget
DB00182AmphetamineMonoamine oxidasetarget
DB00182Amphetaminevesicular monoamine transporter 2 (VMAT2)target
DB06413ArmodafinilCytochrome P450 2C19enzyme
DB06413ArmodafinilCytochrome P450 3A4enzyme
DB06413ArmodafinilCytochrome P450 1A2enzyme
DB06413ArmodafinilCytochrome P450 2B6enzyme
DB06413ArmodafinilCytochrome P450 3A5enzyme
DB06413ArmodafinilCytochrome P450 2C9enzyme
DB06413ArmodafinilSodium-dependent dopamine transportertarget
DB01576DextroamphetamineAlpha-1A adrenergic receptortarget
DB01576DextroamphetamineAlpha-1B adrenergic receptortarget
DB01576DextroamphetamineSodium-dependent dopamine transportertarget
DB01576DextroamphetamineSodium-dependent noradrenaline transportertarget
DB01576DextroamphetamineSynaptic vesicular amine transportertarget
DB01576DextroamphetamineTrace amine-associated receptor 1target
DB01576DextroamphetamineCytochrome P450 2D6enzyme
DB01576DextroamphetaminePrimary amine oxidaseenzyme
DB01576DextroamphetamineSodium-dependent dopamine transportertransporter
DB01577MetamfetamineCytochrome P450 2D6enzyme
DB01577MetamfetamineSolute carrier family 22 member 3transporter
DB01577MetamfetamineSolute carrier family 22 member 5transporter
DB01577MetamfetamineSodium-dependent dopamine transportertarget
DB01577MetamfetamineSynaptic vesicular amine transportertarget
DB01577MetamfetamineTrace amine-associated receptor 1target
DB01577MetamfetamineSodium-dependent serotonin transportertarget
DB01577MetamfetamineSodium-dependent noradrenaline transportertarget
DB01577MetamfetamineChromaffin granule amine transportertarget
DB01577MetamfetamineAmine oxidase [flavin-containing] Atarget
DB01577MetamfetamineAmine oxidase [flavin-containing] Btarget
DB01577MetamfetamineAlpha-2A adrenergic receptortarget
DB01577MetamfetamineAlpha-2B adrenergic receptortarget
DB01577MetamfetamineAlpha-2C adrenergic receptortarget
DB00422MethylphenidateSodium-dependent dopamine transportertarget
DB00422MethylphenidateSodium-dependent noradrenaline transportertarget
DB00422MethylphenidateCarboxylesteraseenzyme
DB00422Methylphenidate5-hydroxytryptamine receptor 1Atarget
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DB11642PitolisantHistamine H3 receptortarget
DB11642PitolisantCytochrome P450 3A4enzyme
DB11642PitolisantCytochrome P450 2D6enzyme
DB11642PitolisantCytochrome P450 1A2enzyme
DB11642PitolisantCytochrome P450 2B6enzyme
DB11642PitolisantSolute carrier family 22 member 1transporter
DB11642PitolisantPotassium voltage-gated channel subfamily H member 2target
DB09072Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
DB09072Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme
DB14754SolriamfetolSolute carrier family 22 member 2transporter
DB14754SolriamfetolSolute carrier family 22 member 4transporter
DB14754SolriamfetolSolute carrier family 22 member 5transporter
DB14754SolriamfetolSodium-dependent dopamine transportertarget
DB14754SolriamfetolSodium-dependent noradrenaline transportertarget
DrugDrug NamePhaseStatusCount
DB09072Sodium oxybate0Recruiting1
DB06413Armodafinil1Completed1
DB00745Modafinil1Completed1
DB00201Caffeine1 / 2Completed1
DB01211Clarithromycin2Completed1
DB01195Flecainide2Completed1
DB00745Modafinil2Completed2
DB12201PF-036547462Completed1
DB00234Reboxetine2Active Not Recruiting1
DB14835SUVN-G30312Recruiting1
DB14754Solriamfetol2Recruiting1
DB06413Armodafinil3Completed4
DB00745Modafinil3Completed6
DB11642Pitolisant3Completed4
DB09072Sodium oxybate3Completed3
DB09072Sodium oxybate3Recruiting1
DB14754Solriamfetol3Completed2
DB06413ArmodafinilNot AvailableRecruiting1
DB00745ModafinilNot AvailableCompleted2
DB00745ModafinilNot AvailableRecruiting1