Partial Seizures

Also known as: Focal Onset Seizure / Partial-onset Seizures With or Without Secondary Generalisation / Partial Onset Epilepsy / Partial Seizures With or Without Secondary Generalization / Focal-Onset Seizures / Epilepsy With Partial-onset Seizures / Partial-Onset Seizures / Partial Seizures (With or Without Secondary Generalized Seizures) / Focal Onset Epilepsy / Focal-Onset Seizure / Focal Seizures / Epilepsy With Partial Onset Seizures With or Without Secondary Generalization / Focal Onset Seizures / Epilepsy With Partial On-set Seizures / Seizure Disorder, Partial / Partial Seizure Disorder / Partial Seizure / Partial onset Seizure Epilepsy / Partial onset Seizures / Partial onset Seizure / Focal seizure / Focal fits / Convulsions local / Seizures, Focal / Focal onset epileptic seizure (finding) / Partial seizures NOS / Localisation related epilepsy / Focal epilepsy / Localization related epilepsy / Focal epilepsy (disorder) / Partial epilepsy / Epilepsies, Partial

DrugDrug NameDrug Description
DB05541BrivaracetamAn anticonvulsant used for the treatment of partial-onset seizures that functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain.
DB06119CenobamateA small molecule drug indicated to treat partial onset seizures in adults.
DB00628Clorazepic acidA benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal.
DB09119Eslicarbazepine acetateAn anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy.
DB00996GabapentinAn anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
DB15985Gamma-amino-beta-hydroxybutyric acidAn anticonvulsant indicated to treat convulsions in children and epilepsy.
DB06218LacosamideAn antiepileptic drug used to treat partial-onset seizures and primary generalized tonic-clonic seizures.
DB00555LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
DB01202LevetiracetamA novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.
DB09543Methyl salicylateA topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons.
DB00776OxcarbazepineAn anti-epileptic used in the treatment of partial-onset seizures.
DB08883PerampanelA non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.
DB01174PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
DB00252PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
DB00230PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
DB00794PrimidoneAn antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures.
DB00906TiagabineAn antiepileptic used to treat partial seizures.
DB00273TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
DB00909ZonisamideA sulfonamide anticonvulsant used to treat partial seizures.
DrugDrug NameTargetType
DB05541BrivaracetamSynaptic vesicle glycoprotein 2Atarget
DB05541BrivaracetamSodium channel proteintarget
DB05541BrivaracetamCytochrome P450 3A4enzyme
DB05541BrivaracetamCytochrome P450 2C19enzyme
DB05541BrivaracetamCytochrome P450 2B6enzyme
DB05541BrivaracetamCytochrome P450 2C9enzyme
DB06119CenobamateUDP-glucuronosyltransferase 2B7enzyme
DB06119CenobamateUDP-glucuronosyltransferase 2B4enzyme
DB06119CenobamateCytochrome P450 2E1enzyme
DB06119CenobamateCytochrome P450 2A6enzyme
DB06119CenobamateCytochrome P450 2B6enzyme
DB06119CenobamateCytochrome P450 2C19enzyme
DB06119CenobamateCytochrome P450 3A4enzyme
DB06119CenobamateCytochrome P450 3A5enzyme
DB06119CenobamateSerum albumincarrier
DB06119CenobamateCytochrome P450 2C8enzyme
DB00628Clorazepic acidCytochrome P450 3A4enzyme
DB00628Clorazepic acidGABA(A) Receptortarget
DB00628Clorazepic acidGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB09119Eslicarbazepine acetateCytochrome P450 2C19enzyme
DB09119Eslicarbazepine acetateCytochrome P450 3A4enzyme
DB09119Eslicarbazepine acetateP2X purinoceptor 4target
DB09119Eslicarbazepine acetateUDP-glucuronosyltransferase 1-1enzyme
DB00996GabapentinAdenosine receptor A1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00996GabapentinVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB00996GabapentinBranched-chain-amino-acid aminotransferase, cytosolicenzyme
DB00996GabapentinLarge neutral amino acids transporter small subunit 1transporter
DB00996GabapentinVoltage-dependent N-type calcium channeltarget
DB00996GabapentinPotassium voltage-gated channel subfamily KQT member 3target
DB00996GabapentinPotassium voltage-gated channel subfamily KQT member 5target
DB06218LacosamideSodium channel protein type 9 subunit alphatarget
DB06218LacosamideSodium channel protein type 3 subunit alphatarget
DB06218LacosamideSodium channel protein type 10 subunit alphatarget
DB06218LacosamideCytochrome P450 2C19enzyme
DB06218LacosamideCytochrome P450 2C9enzyme
DB06218LacosamideCytochrome P450 3A4enzyme
DB00555LamotrigineVoltage-gated sodium channel alpha subunittarget
DB00555LamotrigineUDP-glucuronosyltransferases (UGTs)enzyme
DB00555LamotrigineP-glycoprotein 1transporter
DB00555LamotrigineDihydrofolate reductaseenzyme
DB00555Lamotrigine5-hydroxytryptamine receptor 3Atarget
DB00555LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
DB00555LamotrigineAdenosine receptor A1target
DB00555LamotrigineAdenosine receptor A2atarget
DB00555LamotrigineAlpha-1A adrenergic receptortarget
DB00555LamotrigineAlpha-2A adrenergic receptortarget
DB00555LamotrigineBeta-1 adrenergic receptortarget
DB00555LamotrigineD(1) dopamine receptortarget
DB00555LamotrigineDopamine D2 receptortarget
DB00555LamotrigineGABA(A) Receptortarget
DB00555LamotrigineGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00555LamotrigineHistamine H1 receptortarget
DB00555LamotrigineKappa-type opioid receptortarget
DB00555LamotrigineAcetylcholine receptor subunit alphatarget
DB00555Lamotrigine5-hydroxytryptamine receptor 2Atarget
DB00555LamotrigineSolute carrier family 22 member 2transporter
DB00555LamotrigineSerum albumincarrier
DB00555LamotrigineSolute carrier family 22 member 1transporter
DB00555LamotrigineGlutamate receptor 1target
DB01202LevetiracetamSynaptic vesicle glycoprotein 2Atarget
DB01202LevetiracetamP-glycoprotein 1transporter
DB01202LevetiracetamVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00776OxcarbazepineCytochrome P450 2C19enzyme
DB00776OxcarbazepineCytochrome P450 3A4enzyme
DB00776OxcarbazepineCytochrome P450 3A5enzyme
DB00776OxcarbazepineSerum albumincarrier
DB00776OxcarbazepineP-glycoprotein 1transporter
DB00776OxcarbazepineAldo-keto reductase family 1 member C1enzyme
DB00776OxcarbazepineAldo-keto reductase family 1 member C2enzyme
DB00776OxcarbazepineAldo-keto reductase family 1 member C3enzyme
DB00776OxcarbazepineAldo-keto reductase family 1 member C4enzyme
DB00776OxcarbazepineCarbonyl reductase [NADPH] 1enzyme
DB00776OxcarbazepineCarbonyl reductase [NADPH] 3enzyme
DB00776OxcarbazepineSodium channel proteintarget
DB08883PerampanelGlutamate receptor 1target
DB08883PerampanelCytochrome P450 3A4enzyme
DB08883PerampanelCytochrome P450 3A5enzyme
DB08883PerampanelCytochrome P450 1A2enzyme
DB08883PerampanelCytochrome P450 2B6enzyme
DB01174PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
DB01174PhenobarbitalCytochrome P450 2C19enzyme
DB01174PhenobarbitalCytochrome P450 2C9enzyme
DB01174PhenobarbitalCytochrome P450 2B6enzyme
DB01174PhenobarbitalCytochrome P450 2C8enzyme
DB01174PhenobarbitalCytochrome P450 1A2enzyme
DB01174PhenobarbitalCytochrome P450 3A4enzyme
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
DB01174PhenobarbitalBile salt export pumptransporter
DB01174PhenobarbitalP-glycoprotein 1transporter
DB01174PhenobarbitalMultidrug resistance-associated protein 1transporter
DB01174PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
DB01174PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
DB01174PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
DB01174PhenobarbitalGlutamate receptor 2target
DB01174PhenobarbitalGlutamate receptor ionotropic, kainate 2target
DB01174PhenobarbitalCytochrome P450 2A6enzyme
DB01174PhenobarbitalCytochrome P450 2E1enzyme
DB01174PhenobarbitalCytochrome P450 3A5enzyme
DB01174PhenobarbitalCytochrome P450 1A1enzyme
DB01174PhenobarbitalCytochrome P450 2C18enzyme
DB01174PhenobarbitalCytochrome P450 3A7enzyme
DB01174PhenobarbitalCytochrome P450 4B1enzyme
DB01174PhenobarbitalNMDA receptortarget
DB01174PhenobarbitalNuclear receptor subfamily 1 group I member 2target
DB01174PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
DB01174PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
DB00252PhenytoinSodium channel protein type 5 subunit alphatarget
DB00252PhenytoinSodium channel protein type 1 subunit alphatarget
DB00252PhenytoinCytochrome P450 2C8enzyme
DB00252PhenytoinCytochrome P450 2C19enzyme
DB00252PhenytoinCytochrome P450 2C9enzyme
DB00252PhenytoinCytochrome P450 2B6enzyme
DB00252PhenytoinCytochrome P450 3A5enzyme
DB00252PhenytoinSerum albumincarrier
DB00252PhenytoinCytochrome P450 3A4enzyme
DB00252PhenytoinSolute carrier organic anion transporter family member 1C1transporter
DB00252PhenytoinP-glycoprotein 1transporter
DB00252PhenytoinCanalicular multispecific organic anion transporter 1transporter
DB00252PhenytoinCytochrome P450 11B1, mitochondrialenzyme
DB00252PhenytoinCytochrome P450 3A7enzyme
DB00252PhenytoinNuclear receptor subfamily 1 group I member 2target
DB00252PhenytoinSodium channel subunit beta-1target
DB00252PhenytoinSodium channel protein type 3 subunit alphatarget
DB00252PhenytoinUDP-glucuronosyltransferase 1-1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-6enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-9enzyme
DB00252PhenytoinThyroxine-binding globulincarrier
DB00252PhenytoinPotassium voltage-gated channel subfamily H member 2target
DB00252PhenytoinVoltage-dependent L-type calcium channeltarget
DB00252PhenytoinSodium channel protein type 2 subunit alphatarget
DB00252PhenytoinSodium channel protein type 8 subunit alphatarget
DB00252PhenytoinGABA(A) Receptortarget
DB00252PhenytoinCytochrome P450 1A2enzyme
DB00252PhenytoinCytochrome P450 2A6enzyme
DB00252PhenytoinCytochrome P450 2D6enzyme
DB00252PhenytoinCytochrome P450 2E1enzyme
DB00252PhenytoinEpoxide hydrolase 1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-4enzyme
DB00252PhenytoinCatechol O-methyltransferaseenzyme
DB00252PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00252PhenytoinCytochrome P450 2C18enzyme
DB00230PregabalinExcitatory amino acid transporter 3transporter
DB00230PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00230PregabalinLarge neutral amino acids transporter small subunit 1transporter
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-1target
DB00794PrimidoneCytochrome P450 2C19enzyme
DB00794PrimidoneCytochrome P450 2C9enzyme
DB00794PrimidoneCytochrome P450 3A4enzyme
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-2target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-3target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-4target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-5target
DB00794PrimidoneGamma-aminobutyric acid receptor subunit alpha-6target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-4target
DB00794PrimidoneNeuronal acetylcholine receptor subunit alpha-7target
DB00794PrimidoneGlutamate receptor 2target
DB00794PrimidoneGlutamate receptor ionotropic, kainate 2target
DB00794PrimidoneGABA(A) Receptortarget
DB00794PrimidoneTransient receptor potential cation channel subfamily M member 3transporter
DB00794PrimidoneCytochrome P450 2E1enzyme
DB00794PrimidoneCytochrome P450 1A2enzyme
DB00794PrimidoneUDP-glucuronosyltransferases (UGTs)enzyme
DB00906TiagabineSodium- and chloride-dependent GABA transporter 1target
DB00906TiagabineCytochrome P450 3A4enzyme
DB00906TiagabineUDP-glucuronosyltransferase 1-1enzyme
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateVoltage-gated sodium channel alpha subunittarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateKainate receptorstarget
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateVoltage gated L-type calcium channeltarget
DB00273TopiramateVoltage-dependent R-type calcium channeltarget
DB00273TopiramateSerum albumincarrier
DB00273TopiramateP-glycoprotein 1transporter
DB00273Topiramate5'-AMP-activated protein kinasetransporter
DB00909ZonisamideSodium channel protein type 1 subunit alphatarget
DB00909ZonisamideCarbonic anhydrase 1target
DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00909ZonisamideCytochrome P450 3A4enzyme
DB00909ZonisamideAldehyde oxidaseenzyme
DB00909ZonisamideAmine oxidase [flavin-containing] Btarget
DB00909ZonisamideCarbonic anhydrase 2target
DB00909ZonisamideCarbonic anhydrase 3target
DB00909ZonisamideCarbonic anhydrase 4target
DB00909ZonisamideCarbonic anhydrase 5A, mitochondrialtarget
DB00909ZonisamideCarbonic anhydrase 5B, mitochondrialtarget
DB00909ZonisamideCarbonic anhydrase 6target
DB00909ZonisamideCarbonic anhydrase 7target
DB00909ZonisamideCarbonic anhydrase-related proteintarget
DB00909ZonisamideCarbonic anhydrase 9target
DB00909ZonisamideCarbonic anhydrase-related protein 10target
DB00909ZonisamideCarbonic anhydrase-related protein 11target
DB00909ZonisamideCarbonic anhydrase 12target
DB00909ZonisamideCarbonic anhydrase 13target
DB00909ZonisamideCarbonic anhydrase 14target
DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00909ZonisamideSodium channel protein type 2 subunit alphatarget
DB00909ZonisamideSodium channel protein type 3 subunit alphatarget
DB00909ZonisamideSodium channel protein type 4 subunit alphatarget
DB00909ZonisamideSodium channel protein type 5 subunit alphatarget
DB00909ZonisamideSodium channel protein type 9 subunit alphatarget
DB00909ZonisamideSodium channel protein type 11 subunit alphatarget
DB00909ZonisamideSodium channel subunit beta-1target
DB00909ZonisamideSodium channel subunit beta-2target
DB00909ZonisamideSodium channel subunit beta-3target
DB00909ZonisamideSodium channel subunit beta-4target
DB00909ZonisamideAmine oxidase [flavin-containing] Atarget
DB00909ZonisamideCytochrome P450 2C19enzyme
DB00909ZonisamideUDP-glucuronosyltransferase 1-1enzyme
DB00909ZonisamideCytochrome P450 3A5enzyme
DB00909ZonisamideP-glycoprotein 1transporter
DB00909ZonisamideGABA(A) Receptor Benzodiazepine Binding Sitetarget
DrugDrug NamePhaseStatusCount
DB05541Brivaracetam1Active Not Recruiting1
DB09119Eslicarbazepine acetate1Completed1
DB00977Ethinylestradiol1Completed1
DB00367Levonorgestrel1Completed1
DB08883Perampanel1Completed2
DB14050Cannabidivarin2Completed2
DB12059JNJ-404118132Completed1
DB01202Levetiracetam2Completed1
DB14977Padsevonil2Completed1
DB14977Padsevonil2Terminated1
DB08883Perampanel2Recruiting1
DB12367Selurampanel2Completed2
DB12367Selurampanel2Withdrawn1
DB00776Oxcarbazepine2 / 3Completed1
DB05541Brivaracetam3Completed2
DB05541Brivaracetam3Enrolling by Invitation1
DB00564Carbamazepine3Completed1
DB06119Cenobamate3Active Not Recruiting1
DB06218Lacosamide3Completed8
DB01202Levetiracetam3Completed6
DB14977Padsevonil3Terminated1
DB08883Perampanel3Completed2
DB00230Pregabalin3Completed8
DB00273Topiramate3Completed1
DB00313Valproic acid3Completed1
DB00313Valproic acid3Terminated1
DB00909Zonisamide3Completed2
DB00564Carbamazepine4Completed1
DB09119Eslicarbazepine acetate4Completed1
DB00996Gabapentin4Completed1
DB00776Oxcarbazepine4Completed1
DB08883Perampanel4Completed1
DB00230Pregabalin4Completed2
DB00230Pregabalin4Terminated1
DB00909Zonisamide4Completed1
DB09119Eslicarbazepine acetateNot AvailableCompleted1
DB06218LacosamideNot AvailableCompleted1
DB06218LacosamideNot AvailableNot Yet Recruiting1
DB08883PerampanelNot AvailableCompleted6
DB08883PerampanelNot AvailableNo Longer Available1
DB00909ZonisamideNot AvailableCompleted1