Vascular Headache

Also known as: Vascular Headaches / Headache vascular / Vascular headache (disorder)

Drug	Drug Name	Drug Description
DB00201	Caffeine	A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB01495	Dichloralphenazone	Dichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension...
DB00696	Ergotamine	An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches.
DB13520	Metergoline	An ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. It is often used in situations where inhibition of prolactin is desirable.

Drug	Drug Name	Target	Type
DB00201	Caffeine	Adenosine receptor A1	target
DB00201	Caffeine	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	target
DB00201	Caffeine	Adenosine receptor A2a	target
DB00201	Caffeine	Cytochrome P450 1A2	enzyme
DB00201	Caffeine	Ryanodine receptor 1	target
DB00201	Caffeine	Cytochrome P450 3A4	enzyme
DB00201	Caffeine	Cytochrome P450 2E1	enzyme
DB00201	Caffeine	Cytochrome P450 2C8	enzyme
DB00201	Caffeine	Cytochrome P450 2C9	enzyme
DB00201	Caffeine	Cytochrome P450 1A1	enzyme
DB00201	Caffeine	Cytochrome P450 1B1	enzyme
DB00201	Caffeine	Cytochrome P450 2D6	enzyme
DB00201	Caffeine	Cyclic nucleotide phosphodiesterase	target
DB00201	Caffeine	DNA-dependent protein kinase catalytic subunit	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	target
DB00201	Caffeine	Inositol 1,4,5-trisphosphate receptor	target
DB00201	Caffeine	Serine-protein kinase ATM	target
DB00201	Caffeine	ATP-binding cassette sub-family G member 2	transporter
DB00201	Caffeine	Adenosine receptor A2b	target
DB00201	Caffeine	Adenosine receptor A3	target
DB00201	Caffeine	Phosphodiesterase enzymes	target
DB00696	Ergotamine	Alpha-1A adrenergic receptor	target
DB00696	Ergotamine	5-hydroxytryptamine receptor 1D	target
DB00696	Ergotamine	5-hydroxytryptamine receptor 1B	target
DB00696	Ergotamine	5-hydroxytryptamine receptor 2A	target
DB00696	Ergotamine	Alpha-2A adrenergic receptor	target
DB00696	Ergotamine	Dopamine D2 receptor	target
DB00696	Ergotamine	Cytochrome P450 3A4	enzyme
DB00696	Ergotamine	Alpha-1B adrenergic receptor	target
DB00696	Ergotamine	Alpha-1D adrenergic receptor	target
DB00696	Ergotamine	P-glycoprotein 1	transporter
DB00696	Ergotamine	D(1) dopamine receptor	target
DB00696	Ergotamine	5-hydroxytryptamine receptor 1A	target
DB00696	Ergotamine	5-hydroxytryptamine receptor 1F	target
DB00696	Ergotamine	5-hydroxytryptamine receptor 2C	target
DB00696	Ergotamine	5-hydroxytryptamine receptor 2B	target
DB00696	Ergotamine	Alpha-2C adrenergic receptor	target
DB13520	Metergoline	Sodium channel protein type 2 subunit alpha	target

Drug	Drug Name	Phase	Status	Count
DB00273	Topiramate	3	Completed	1