Headache

Also known as: Headaches / Headaches NEC / [D]Headache / Headache NOS / Cephalalgia / Cephalgia / Pain head / Head pain / Facial pain NOS

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB00201CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB14006Choline salicylateThe oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due...
DB04272Citric acidAn anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.
DB11278DL-MethylephedrineUsed as an antitussive and decongestant .
DB01050IbuprofenAn NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.
DB00788NaproxenAn NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidP-glycoprotein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineATP-binding cassette sub-family G member 2transporter
DB00201CaffeineAdenosine receptor A2btarget
DB00201CaffeineAdenosine receptor A3target
DB00201CaffeinePhosphodiesterase enzymestarget
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Btarget
DB14006Choline salicylateAcetylcholinesterasetarget
DB14006Choline salicylateCholine-phosphate cytidylyltransferase Atarget
DB14006Choline salicylatePhospholipase D2target
DB14006Choline salicylateCholinesterasetarget
DB14006Choline salicylatePhospholipase D1target
DB14006Choline salicylatePhosphoethanolamine/phosphocholine phosphatasetarget
DB14006Choline salicylateSolute carrier family 22 member 2transporter
DB14006Choline salicylateSolute carrier family 22 member 1transporter
DB14006Choline salicylateSolute carrier family 22 member 3transporter
DB14006Choline salicylateSolute carrier family 22 member 5transporter
DB14006Choline salicylateSolute carrier family 22 member 4transporter
DB14006Choline salicylateCholine/ethanolaminephosphotransferase 1enzyme
DB14006Choline salicylateCholine transporter-like protein 1transporter
DB14006Choline salicylateCholine transporter-like protein 4transporter
DB14006Choline salicylateCholine transporter-like protein 2transporter
DB14006Choline salicylateCholine transporter-like protein 3transporter
DB14006Choline salicylateCholine/ethanolamine kinaseenzyme
DB14006Choline salicylateCholine O-acetyltransferaseenzyme
DB14006Choline salicylateCholine kinase alphaenzyme
DB14006Choline salicylateCholine dehydrogenase, mitochondrialenzyme
DB14006Choline salicylateHigh affinity choline transporter 1transporter
DB14006Choline salicylateNeuronal acetylcholine receptor subunit alpha-7target
DB04272Citric acidCell division protein FtsZtarget
DB04272Citric acidAngiogenintarget
DB04272Citric acidBeta-lactamase 2target
DB04272Citric acidUridine-cytidine kinase 2target
DB04272Citric acidTumor necrosis factor ligand superfamily member 13Btarget
DB04272Citric acidBetaine--homocysteine S-methyltransferase 1target
DB04272Citric acidTryptophan--tRNA ligasetarget
DB04272Citric acidAldose reductasetarget
DB04272Citric acidCitrate synthase, mitochondrialtarget
DB04272Citric acidHeparan sulfate glucosamine 3-O-sulfotransferase 3A1target
DB04272Citric acidcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB04272Citric acidProto-oncogene tyrosine-protein kinase Srctarget
DB04272Citric acidRibonuclease pancreatictarget
DB04272Citric acidIsocitrate dehydrogenase [NADP]target
DB04272Citric acidGlycine N-methyltransferasetarget
DB04272Citric acidEosinophil cationic proteintarget
DB04272Citric acidBeta-lactamasetarget
DB04272Citric acidMolybdenum cofactor guanylyltransferasetarget
DB04272Citric acidFumarate hydratase class IItarget
DB04272Citric acid6-phosphogluconolactonasetarget
DB04272Citric acidOxygen-insensitive NAD(P)H nitroreductasetarget
DB04272Citric acidGag-Pro-Pol polyproteintarget
DB04272Citric acidL-amino-acid oxidasetarget
DB04272Citric acidMacrophage migration inhibitory factortarget
DB04272Citric acidCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target
DB04272Citric acid1-deoxy-D-xylulose 5-phosphate reductoisomerasetarget
DB04272Citric acidTryptophan synthase alpha chaintarget
DB04272Citric acidSialidasetarget
DB04272Citric acidKHG/KDPG aldolasetarget
DB04272Citric acidCytochrome c peroxidasetarget
DB04272Citric acidHepatocyte growth factor-regulated tyrosine kinase substratetarget
DB04272Citric acidInvasintarget
DB04272Citric acidIntron-associated endonuclease 1target
DB04272Citric acidShort tail fiber proteintarget
DB04272Citric acidMalate dehydrogenase, mitochondrialtarget
DB04272Citric acidN5-carboxyaminoimidazole ribonucleotide mutasetarget
DB04272Citric acid50S ribosomal protein L4target
DB04272Citric acidCarboxypeptidase Btarget
DB04272Citric acidHexon proteintarget
DB04272Citric acidRiboflavin biosynthesis protein RibFtarget
DB04272Citric acidBeta-fructosidasetarget
DB04272Citric acidPutative stringent starvation protein Atarget
DB04272Citric acidCitrate synthasetarget
DB04272Citric acidRNA 3'-terminal phosphate cyclasetarget
DB04272Citric acidU6 snRNA-associated Sm-like protein LSm6target
DB04272Citric acidPleckstrin homology domain-containing family A member 1target
DB04272Citric acidFe(3+)-binding periplasmic proteintarget
DB04272Citric acidSignal recognition particle receptor FtsYtarget
DB04272Citric acidNicotinate-nucleotide adenylyltransferasetarget
DB04272Citric acidN utilization substance protein B homologtarget
DB04272Citric acidComplement component C8 gamma chaintarget
DB04272Citric acidRibonucleoside-diphosphate reductase subunit betatarget
DB04272Citric acidGlutamine synthetase 1target
DB04272Citric acidCitrate synthasetarget
DB04272Citric acidProstaglandin F synthasetarget
DB04272Citric acidAdenine phosphoribosyltransferasetarget
DB04272Citric acidGlucose-1-phosphate thymidylyltransferasetarget
DB04272Citric acidGlyoxalase family proteintarget
DB04272Citric acidLaccase domain protein YfiHtarget
DB04272Citric acidRibose-5-phosphate isomerase Atarget
DB04272Citric acidGMP synthase [glutamine-hydrolyzing]target
DB04272Citric acidInosine triphosphate pyrophosphatasetarget
DB04272Citric acidLysozymetarget
DB04272Citric acidGlycerol uptake operon antiterminator regulatory proteintarget
DB04272Citric acid3-carboxy-cis,cis-muconate cycloisomerasetarget
DB04272Citric acidPyruvate decarboxylasetarget
DB04272Citric acidSolute carrier organic anion transporter family member 2B1transporter
DB11278DL-MethylephedrineBeta-1 adrenergic receptortarget
DB11278DL-MethylephedrineAlpha-2A adrenergic receptortarget
DB11278DL-MethylephedrineAlpha adrenergic receptortarget
DB11278DL-MethylephedrineBeta adrenergic receptortarget
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenP-glycoprotein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB01050IbuprofenCytochrome P450 3A4enzyme
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenP-glycoprotein 1transporter
DB00788NaproxenUDP-glucuronosyltransferase 1-3enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-6enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-7enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-9enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-10enzyme
DB00788NaproxenSolute carrier family 22 member 8transporter
DrugDrug NamePhaseStatusCount
DB00281Lidocaine1Recruiting1
DB00959Methylprednisolone1Recruiting1
DB14007Pentetic acid1 / 2Terminated1
DB00457Prazosin1 / 2Recruiting1
DB09153Sodium chloride1 / 2Completed1
DB01593Zinc1 / 2Terminated1
DB00321Amitriptyline2Recruiting1
DB00297Bupivacaine2Completed1
DB09157Carbon dioxide2Completed1
DB00633Dexmedetomidine2Completed1
DB12158Filorexant2Completed1
DB00273Topiramate2Completed1
DB00273Topiramate2Withdrawn1
DB00653Magnesium sulfate2 / 3Withdrawn1
DB01233Metoclopramide2 / 3Withdrawn1
DB00316Acetaminophen3Terminated1
DB00945Acetylsalicylic acid3Terminated1
DB00321Amitriptyline3Terminated1
DB00321Amitriptyline3Unknown Status1
DB00083Botulinum toxin type A3Completed1
DB00297Bupivacaine3Completed1
DB00201Caffeine3Unknown Status1
DB01234Dexamethasone3Completed1
DB01234Dexamethasone3Terminated1
DB01050Ibuprofen3Unknown Status1
DB01221Ketamine3Completed1
DB01221Ketamine3Terminated1
DB00465Ketorolac3Completed1
DB01233Metoclopramide3Completed1
DB00788Naproxen3Withdrawn2
DB00952Naratriptan3Withdrawn2
DB06614Peramivir3Completed1
DB06614Peramivir3Terminated1
DB00860Prednisolone3Completed1
DB00433Prochlorperazine3Terminated1
DB00571Propranolol3Completed1
DB00273Topiramate3Completed4
DB00273Topiramate3Terminated1
DB00316Acetaminophen4Completed2
DB00316Acetaminophen4Enrolling by Invitation1
DB00316Acetaminophen4Not Yet Recruiting1
DB00945Acetylsalicylic acid4Completed1
DB00321Amitriptyline4Terminated1
DB00297Bupivacaine4Recruiting1
DB00201Caffeine4Not Yet Recruiting1
DB01234Dexamethasone4Recruiting1
DB00633Dexmedetomidine4Recruiting1
DB01075Diphenhydramine4Completed1
DB01075Diphenhydramine4Recruiting1
DB01628Etoricoxib4Completed1
DB01628Etoricoxib4Unknown Status1
DB00813Fentanyl4Not Yet Recruiting1
DB00502Haloperidol4Completed1
DB00741Hydrocortisone4Completed1
DB01050Ibuprofen4Completed1
DB01221Ketamine4Completed1
DB00465Ketorolac4Completed1
DB00465Ketorolac4Enrolling by Invitation1
DB00742Mannitol4Completed1
DB01233Metoclopramide4Completed1
DB00334Olanzapine4Completed1
DB00904Ondansetron4Completed1
DB00230Pregabalin4Withdrawn1
DB00433Prochlorperazine4Completed1
DB00433Prochlorperazine4Recruiting1
DB00818Propofol4Recruiting1
DB00571Propranolol4Terminated1
DB00852Pseudoephedrine4Completed1
DB09153Sodium chloride4Completed1
DB09153Sodium chloride4Recruiting1
DB08816Ticagrelor4Completed1
DB00273Topiramate4Completed1
DB00273Topiramate4Terminated1
DB00193Tramadol4Completed1
DB00620Triamcinolone4Recruiting1
DB00316AcetaminophenNot AvailableCompleted2
DB00819AcetazolamideNot AvailableCompleted1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic acidNot AvailableRecruiting1
DB00181BaclofenNot AvailableCompleted1
DB00559BosentanNot AvailableRecruiting1
DB00083Botulinum toxin type ANot AvailableActive Not Recruiting1
DB00083Botulinum toxin type ANot AvailableCompleted1
DB00297BupivacaineNot AvailableCompleted1
DB06774CapsaicinNot AvailableCompleted1
DB00411CarbamoylcholineNot AvailableCompleted2
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00318CodeineNot AvailableCompleted1
DB00924CyclobenzaprineNot AvailableCompleted1
DB00586DiclofenacNot AvailableCompleted1
DB12789DinoprostNot AvailableCompleted1
DB01075DiphenhydramineNot AvailableCompleted1
DB01240EpoprostenolNot AvailableUnknown Status1
DB00977EthinylestradiolNot AvailableCompleted1
DB14491Ferrous fumarateNot AvailableCompleted1
DB00712FlurbiprofenNot AvailableCompleted1
DB00828FosfomycinNot AvailableRecruiting1
DB00996GabapentinNot AvailableCompleted1
DB00502HaloperidolNot AvailableRecruiting1
DB01050IbuprofenNot AvailableCompleted2
DB01221KetamineNot AvailableCompleted2
DB00598LabetalolNot AvailableRecruiting1
DB00825LevomentholNot AvailableCompleted2
DB00281LidocaineNot AvailableCompleted1
DB08815LurasidoneNot AvailableRecruiting1
DB09337Medical airNot AvailableCompleted1
DB00814MeloxicamNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01233MetoclopramideNot AvailableCompleted1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00717NorethisteroneNot AvailableCompleted1
DB00497OxycodoneNot AvailableRecruiting1
DB09140OxygenNot AvailableCompleted1
DB00652PentazocineNot AvailableCompleted1
DB00312PentobarbitalNot AvailableRecruiting1
DB00319PiperacillinNot AvailableRecruiting1
DB00750PrilocaineNot AvailableCompleted1
DB00818PropofolNot AvailableRecruiting1
DB00728RocuroniumNot AvailableRecruiting1
DB00533RofecoxibNot AvailableCompleted1
DB00296RopivacaineNot AvailableCompleted1
DB00658SevelamerNot AvailableRecruiting1
DB01236SevofluraneNot AvailableRecruiting1
DB09153Sodium chlorideNot AvailableCompleted1
DB00421SpironolactoneNot AvailableRecruiting1
DB00669SumatriptanNot AvailableCompleted1
DB01606TazobactamNot AvailableRecruiting1
DB00697TizanidineNot AvailableCompleted1
DB00684TobramycinNot AvailableRecruiting1
DB00273TopiramateNot AvailableCompleted1
DB00273TopiramateNot AvailableWithdrawn1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1