Bacteremia

Also known as: Bacteraemia / [D]Unspecified bacteremia / Unspecified bacteraemia / Bacteraemia, unspecified / Unspecified bacteremia / Bacteremia, unspecified

DrugDrug NameDrug Description
DB01053BenzylpenicillinBenzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as *Bacillus anthracis*, *Corynebacterium diphtheriae*, and *Erysipelothrix rhusiopathiae*. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by *Neisseria meningitidis* and *Pasteurella*. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
DB00493CefotaximeCefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
DB00080DaptomycinDaptomycin is a naturally-occurring lipopeptide antibiotic that kills susceptible gram positive bacteria by disrupting their membrane potential. It is found in the soil bacterium called Streptomyces roseosporus. Antibiotics are used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Daptomycin will not work for colds, flu, or other virus infections. It was approved in September 2003 for the treatment of complicated skin and soft tissue infections. It has a safety profile similar to other agents commonly administered to treat gram-positive infections.
DB00916MetronidazoleMetronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics.[L3754] It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A18039] Metronidazole has been used as an antibiotic for several decades[L7429], with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
DB01082StreptomycinStreptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis. It is bactericidal due to effects that are not fully understood.
DrugDrug NameTargetType
DB01053BenzylpenicillinSolute carrier family 22 member 5transporter
DB01053BenzylpenicillinSolute carrier family 15 member 1transporter
DB01053BenzylpenicillinSolute carrier family 15 member 2transporter
DB01053BenzylpenicillinSolute carrier family 22 member 6transporter
DB01053BenzylpenicillinSolute carrier family 22 member 8transporter
DB01053BenzylpenicillinSolute carrier family 22 member 4transporter
DB01053BenzylpenicillinSolute carrier family 22 member 11transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
DB01053BenzylpenicillinPenicillin-binding protein 3target
DB01053BenzylpenicillinBeta-lactamase TEMtarget
DB01053BenzylpenicillinSolute carrier family 22 member 8target
DB01053BenzylpenicillinSolute carrier family 15 member 1target
DB01053BenzylpenicillinSolute carrier family 15 member 2target
DB00493CefotaximePenicillin-binding protein 3target
DB00493CefotaximeSolute carrier family 15 member 1transporter
DB00493CefotaximeSolute carrier family 15 member 2transporter
DB00493CefotaximeSolute carrier family 22 member 6transporter
DB00493CefotaximeSolute carrier family 22 member 8transporter
DB00493CefotaximeSolute carrier family 22 member 11transporter
DB00493CefotaximeSolute carrier family 22 member 7transporter
DB00493CefotaximePenicillin-binding protein 1btarget
DB00493CefotaximePenicillin-binding protein 2atarget
DB00493CefotaximePenicillin-binding protein 1Atarget
DB00493CefotaximePenicillin-binding protein 2Btarget
DB00493CefotaximeSolute carrier family 22 member 6target
DB00493CefotaximeSolute carrier family 22 member 8target
DB00493CefotaximeSolute carrier family 22 member 11target
DB00493CefotaximeSolute carrier family 22 member 7target
DB00493CefotaximeSolute carrier family 15 member 1target
DB00493CefotaximeSerum albumintarget
DB00493CefotaximeBeta-lactamasetarget
DB00493CefotaximeSolute carrier family 15 member 2target
DB00080DaptomycinBacterial outer membranetarget
DB00916MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
DB00916MetronidazoleCytochrome P450 2C9enzyme
DB00916MetronidazoleCytochrome P450 3A4enzyme
DB00916MetronidazoleCytochrome P450 2C8enzyme
DB00916MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
DB00916MetronidazoleAnaerobic bacterial DNAtarget
DB00916MetronidazoleProtozoal DNAtarget
DB00916MetronidazoleP-glycoprotein 1transporter
DB00916MetronidazoleCytochrome P450 2A6enzyme
DB00916MetronidazoleCytochrome P450 3A5enzyme
DB00916MetronidazoleCytochrome P450 3A7enzyme
DB01082Streptomycin30S ribosomal protein S12target
DB01082Streptomycin16S rRNAtarget
DB01082StreptomycinSolute carrier family 22 member 6transporter
DB01082StreptomycinProtein-arginine deiminase type-4target
DrugDrug NamePhaseStatusCount
DB00878Chlorhexidine1Completed1
DB01060Amoxicillin2Active Not Recruiting1
DB01060Amoxicillin2Completed1
DB00415Ampicillin2Recruiting1
DB01327Cefazolin2Completed1
DB00493Cefotaxime2Recruiting1
DB14733Ceftobiprole medocaril2Withdrawn1
DB01147Cloxacillin2Completed1
DB06219Dalbavancin2Terminated1
DB06219Dalbavancin2Unknown Status1
DB00080Daptomycin2Completed1
DB00080Daptomycin2Recruiting1
DB00080Daptomycin2Unknown Status1
DB00798Gentamicin2Recruiting1
DB00607Nafcillin2Completed1
DB00713Oxacillin2Completed1
DB06402Telavancin2Completed1
DB00512Vancomycin2Completed1
DB00803Colistin2 / 3Unknown Status1
DB06211Doripenem2 / 3Unknown Status1
DB00994Neomycin2 / 3Unknown Status1
DB00646Nystatin2 / 3Unknown Status1
DB00781Polymyxin B2 / 3Unknown Status1
DB00512Vancomycin2 / 3Unknown Status1
DB01053Benzylpenicillin3Terminated1
DB01327Cefazolin3Terminated2
DB01147Cloxacillin3Terminated1
DB00803Colistin3Recruiting1
DB00080Daptomycin3Completed1
DB00080Daptomycin3Terminated1
DB00485Dicloxacillin3Completed1
DB00898Ethanol3Unknown Status1
DB01598Imipenem3Recruiting1
DB00601Linezolid3Completed1
DB00601Linezolid3Terminated1
DB00760Meropenem3Completed1
DB00218Moxifloxacin3Completed1
DB00607Nafcillin3Terminated1
DB06610Omiganan3Completed1
DB00713Oxacillin3Completed1
DB00713Oxacillin3Terminated1
DB09324Sulbactam3Recruiting1
DB06402Telavancin3Terminated1
DB12107Vaborbactam3Completed1
DB00512Vancomycin3Completed1
DB00512Vancomycin3Terminated2
DB01060Amoxicillin4Recruiting1
DB01413Cefepime4Completed1
DB06590Ceftaroline fosamil4Completed1
DB06590Ceftaroline fosamil4Terminated1
DB00438Ceftazidime4Terminated1
DB00878Chlorhexidine4Completed2
DB00766Clavulanic acid4Recruiting1
DB00080Daptomycin4Active Not Recruiting1
DB00080Daptomycin4Completed2
DB00080Daptomycin4Terminated2
DB00080Daptomycin4Unknown Status1
DB00668Epinephrine4Completed1
DB00898Ethanol4Completed2
DB00798Gentamicin4Completed1
DB01109Heparin4Completed1
DB01109Heparin4Unknown Status1
DB02325Isopropyl alcohol4Completed2
DB01137Levofloxacin4Completed1
DB00281Lidocaine4Completed1
DB00601Linezolid4Terminated2
DB00601Linezolid4Unknown Status1
DB00760Meropenem4Not Yet Recruiting1
DB00760Meropenem4Terminated1
DB12624Octenidine4Completed1
DB00319Piperacillin4Not Yet Recruiting1
DB00319Piperacillin4Terminated1
DB06812Povidone-iodine4Completed1
DB03175Propyl alcohol4Completed1
DB09153Sodium chloride4Unknown Status1
DB09154Sodium citrate4Completed1
DB01606Tazobactam4Not Yet Recruiting1
DB01606Tazobactam4Terminated1
DB06149Teicoplanin4Unknown Status1
DB00560Tigecycline4Unknown Status1
DB00685Trovafloxacin4Completed1
DB00512Vancomycin4Completed1
DB00512Vancomycin4Not Yet Recruiting1
DB00512Vancomycin4Terminated3
DB00512Vancomycin4Unknown Status1
DB01060AmoxicillinNot AvailableCompleted1
DB00878ChlorhexidineNot AvailableCompleted3
DB00766Clavulanic acidNot AvailableCompleted1
DB00303ErtapenemNot AvailableRecruiting1
DB00898EthanolNot AvailableTerminated1
DB01109HeparinNot AvailableCompleted1
DB08958HexetidineNot AvailableCompleted1
DB05247IodineNot AvailableCompleted1
DB02325Isopropyl alcoholNot AvailableCompleted1
DB06812Povidone-iodineNot AvailableCompleted1
DB11119Sodium iodideNot AvailableCompleted1
DB00512VancomycinNot AvailableCompleted1