Prophylaxis of Malaria

Also known as: Malaria Prophylaxis / Malarial prophylaxis / Administration of prophylactic antimalarial (procedure)

Drug	Drug Name	Drug Description
DB00608	Chloroquine	An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.
DB01087	Primaquine	An antimalarial indicated to prevent relapse of vivax malaria.

Drug	Drug Name	Target	Type
DB00608	Chloroquine	Tumor necrosis factor	target
DB00608	Chloroquine	Toll-like receptor 9	target
DB00608	Chloroquine	Glutathione S-transferase A2	target
DB00608	Chloroquine	Cytochrome P450 2D6	enzyme
DB00608	Chloroquine	Cytochrome P450 3A4	enzyme
DB00608	Chloroquine	Cytochrome P450 1A1	enzyme
DB00608	Chloroquine	Cytochrome P450 2C8	enzyme
DB00608	Chloroquine	Cytochrome P450 3A5	enzyme
DB00608	Chloroquine	Glutathione S-transferase	target
DB00608	Chloroquine	P-glycoprotein 1	transporter
DB00608	Chloroquine	Serum albumin	carrier
DB00608	Chloroquine	alpha1-acid glycoprotein	carrier
DB00608	Chloroquine	High mobility group protein B1	target
DB00608	Chloroquine	Glutathione S-transferase Mu 1	target
DB00608	Chloroquine	Angiotensin-converting enzyme 2	target
DB01087	Primaquine	Cytochrome P450 1A1	enzyme
DB01087	Primaquine	Cytochrome P450 1A2	enzyme
DB01087	Primaquine	Cytochrome P450 3A4	enzyme
DB01087	Primaquine	Keratin, type II cytoskeletal 7	target
DB01087	Primaquine	Cytochrome P450 1B1	enzyme
DB01087	Primaquine	Cytochrome P450 2D6	enzyme
DB01087	Primaquine	Ribosyldihydronicotinamide dehydrogenase [quinone]	target
DB01087	Primaquine	Fe(II)-protoporphyrin IX	target
DB01087	Primaquine	P-glycoprotein 1	transporter

Drug	Drug Name	Phase	Status	Count
DB00207	Azithromycin	1	Completed	1
DB00608	Chloroquine	1	Completed	1