Malaria caused by Plasmodium falciparum

Also known as: MALARIA, FALCIPARUM / Malaria caused by plasmodium falciparum / Falciparum malaria / Malaria,Falciparum / Plasmodium falciparum infection / P.falciparum / Pernicious malaria / Falciparum malaria (malignant tertian) / Plasmodium falciparum malaria

DrugDrug NameDrug Description
DB01117AtovaquoneAn antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.
DB01190ClindamycinA lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.
DB01131ProguanilA medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.
DB00908QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
DB00468QuinineAn alkaloid used to treat uncomplicated Plasmodium falciparum malaria.
DrugDrug NameTargetType
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneCytochrome btarget
DB01117AtovaquoneCytochrome P450 2C9enzyme
DB01117AtovaquoneCytochrome P450 3A4enzyme
DB01117AtovaquoneP-glycoprotein 1transporter
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190ClindamycinCytochrome P450 3A5enzyme
DB01190ClindamycinAlpha-1-acid glycoprotein 1carrier
DB01190ClindamycinP-glycoprotein 1transporter
DB01190Clindamycin50S ribosomal protein L1target
DB01131ProguanilBifunctional dihydrofolate reductase-thymidylate synthasetarget
DB01131ProguanilDihydrofolate reductasetarget
DB01131ProguanilCytochrome P450 2C19enzyme
DB01131ProguanilCytochrome P450 2D6enzyme
DB01131ProguanilCytochrome P450 2C9enzyme
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineP-glycoprotein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00908QuinidineBile salt export pumptransporter
DB00908QuinidineCytochrome P450 2C8enzyme
DB00468QuininePlatelet glycoprotein IXtarget
DB00468QuinineIntermediate conductance calcium-activated potassium channel protein 4target
DB00468QuinineCytochrome P450 3A4enzyme
DB00468QuinineCytochrome P450 3A5enzyme
DB00468QuinineCytochrome P450 1A1enzyme
DB00468QuinineCytochrome P450 2D6enzyme
DB00468QuinineCytochrome P450 1A2enzyme
DB00468QuinineCytochrome P450 2C8enzyme
DB00468QuinineCytochrome P450 2C9enzyme
DB00468QuinineCytochrome P450 2C19enzyme
DB00468QuinineCytochrome P450 2E1enzyme
DB00468QuinineCytochrome P450 3A7enzyme
DB00468QuinineSolute carrier family 22 member 2transporter
DB00468QuinineSolute carrier family 22 member 1transporter
DB00468QuinineSolute carrier family 22 member 5transporter
DB00468QuinineP-glycoprotein 1transporter
DB00468QuinineSolute carrier organic anion transporter family member 1A2transporter
DB00468QuinineSolute carrier family 22 member 4transporter
DB00468QuinineFe(II)-protoporphyrin IXtarget
DB00468QuinineSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB00613Amodiaquine1Completed1
DB11809Artefenomel1Completed1
DB06697Artemether1Completed1
DB06697Artemether1Recruiting1
DB11638Artenimol1Completed1
DB11638Artenimol1Recruiting1
DB09274Artesunate1Completed1
DB01117Atovaquone1Completed1
DB12397DSM-2651Completed1
DB06708Lumefantrine1Completed1
DB06708Lumefantrine1Recruiting1
DB09112Nitrous acid1Not Yet Recruiting1
DB13941Piperaquine1Completed1
DB01131Proguanil1Completed1
DB00205Pyrimethamine1Recruiting1
DB10283Rabies virus inactivated antigen, A1Completed1
DB13085Riamet1Completed1
DB13085Riamet1Recruiting1
DB01299Sulfadoxine1Recruiting1
DB00125Arginine1 / 2Completed1
DB06697Artemether1 / 2Not Yet Recruiting1
DB01117Atovaquone1 / 2Terminated1
DB00207Azithromycin1 / 2Withdrawn1
DB06708Lumefantrine1 / 2Not Yet Recruiting1
DB05144PEV3A1 / 2Completed1
DB13941Piperaquine1 / 2Not Yet Recruiting1
DB01087Primaquine1 / 2Not Yet Recruiting1
DB00205Pyrimethamine1 / 2Not Yet Recruiting1
DB10283Rabies virus inactivated antigen, A1 / 2Recruiting1
DB00412Rosiglitazone1 / 2Completed1
DB01299Sulfadoxine1 / 2Not Yet Recruiting1
DB11809Artefenomel2Completed1
DB06697Artemether2Completed1
DB11638Artenimol2Completed1
DB09274Artesunate2Active Not Recruiting1
DB09274Artesunate2Completed3
DB00207Azithromycin2Completed2
DB00207Azithromycin2Terminated1
DB14547Chloride ion2Completed1
DB00608Chloroquine2Completed1
DB00608Chloroquine2Terminated1
DB11603Human rabies virus immune globulin2Completed1
DB09241Methylene blue2Completed1
DB13941Piperaquine2Completed1
DB01087Primaquine2Completed1
DB12975Pyronaridine2Completed1
DB00468Quinine2Completed1
DB10283Rabies virus inactivated antigen, A2Completed1
DB06697Artemether2 / 3Completed1
DB11638Artenimol2 / 3Completed1
DB09274Artesunate2 / 3Completed2
DB01117Atovaquone2 / 3Completed1
DB00207Azithromycin2 / 3Completed3
DB00207Azithromycin2 / 3Terminated1
DB00608Chloroquine2 / 3Completed3
DB00608Chloroquine2 / 3Terminated1
DB06708Lumefantrine2 / 3Completed1
DB00358Mefloquine2 / 3Completed2
DB13941Piperaquine2 / 3Completed1
DB01087Primaquine2 / 3Completed1
DB01131Proguanil2 / 3Completed1
DB00205Pyrimethamine2 / 3Terminated1
DB01299Sulfadoxine2 / 3Terminated1
DB00316Acetaminophen3Not Yet Recruiting1
DB00613Amodiaquine3Completed2
DB00613Amodiaquine3Not Yet Recruiting1
DB06697Artemether3Completed1
DB11638Artenimol3Completed1
DB11638Artenimol3Not Yet Recruiting1
DB09274Artesunate3Completed4
DB09274Artesunate3Not Yet Recruiting1
DB00608Chloroquine3Completed1
DB12314Chlorproguanil3Completed2
DB10583Clostridium tetani toxoid antigen (formaldehyde inactivated)3Not Yet Recruiting1
DB00250Dapsone3Completed2
DB06708Lumefantrine3Completed1
DB13941Piperaquine3Completed1
DB13941Piperaquine3Not Yet Recruiting1
DB01087Primaquine3Completed2
DB00205Pyrimethamine3Completed1
DB00205Pyrimethamine3Unknown Status1
DB01299Sulfadoxine3Completed1
DB01299Sulfadoxine3Unknown Status1
DB00613Amodiaquine4Active Not Recruiting1
DB00613Amodiaquine4Completed5
DB00613Amodiaquine4Terminated1
DB00613Amodiaquine4Withdrawn1
DB06697Artemether4Completed6
DB06697Artemether4Recruiting1
DB06697Artemether4Terminated1
DB13132Artemisinin4Completed1
DB11638Artenimol4Active Not Recruiting1
DB11638Artenimol4Completed3
DB09274Artesunate4Completed6
DB09274Artesunate4Terminated1
DB09274Artesunate4Unknown Status1
DB09274Artesunate4Withdrawn1
DB00608Chloroquine4Completed3
DB12314Chlorproguanil4Completed2
DB00250Dapsone4Completed2
DB06708Lumefantrine4Completed6
DB06708Lumefantrine4Recruiting1
DB06708Lumefantrine4Terminated1
DB00358Mefloquine4Completed1
DB00358Mefloquine4Unknown Status1
DB13941Piperaquine4Active Not Recruiting1
DB13941Piperaquine4Completed2
DB01087Primaquine4Completed1
DB01087Primaquine4Not Yet Recruiting1
DB01087Primaquine4Recruiting1
DB01131Proguanil4Active Not Recruiting1
DB00205Pyrimethamine4Completed2
DB12975Pyronaridine4Completed1
DB01299Sulfadoxine4Active Not Recruiting1
DB01299Sulfadoxine4Completed2
DB00613AmodiaquineNot AvailableCompleted3
DB06697ArtemetherNot AvailableCompleted3
DB11638ArtenimolNot AvailableCompleted1
DB09274ArtesunateNot AvailableCompleted8
DB01117AtovaquoneNot AvailableCompleted2
DB01117AtovaquoneNot AvailableSuspended1
DB00608ChloroquineNot AvailableCompleted2
DB12496Dihydroxyacetone phosphateNot AvailableActive Not Recruiting1
DB06708LumefantrineNot AvailableCompleted3
DB00358MefloquineNot AvailableCompleted1
DB00358MefloquineNot AvailableSuspended1
DB13941PiperaquineNot AvailableCompleted2
DB01087PrimaquineNot AvailableCompleted1
DB01131ProguanilNot AvailableCompleted2
DB01131ProguanilNot AvailableSuspended1
DB00205PyrimethamineNot AvailableCompleted6
DB13085RiametNot AvailableCompleted1
DB01299SulfadoxineNot AvailableCompleted6