Refractory Small cell lung cancer

Also known as: Small Cell Lung Cancer Recurrent / Recurrent Small Cell Lung Cancer

DrugDrug NameDrug Description
DB00531CyclophosphamidePrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [PubChem]
DB01229PaclitaxelPaclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. [Wikipedia]
DrugDrug NameTargetType
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelMultidrug resistance protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelATP-binding cassette sub-family G member 2transporter
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DrugDrug NamePhaseStatusCount
DB019337-Hydroxystaurosporine1Completed1
DB12109CPI-6131Completed1
DB01248Docetaxel1Terminated1
DB00762Irinotecan1Completed1
DB01229Paclitaxel1Completed1
DB00020Sargramostim1Terminated1
DB06287Temsirolimus1Completed1
DB00072Trastuzumab1Completed1
DB00361Vinorelbine1Completed1
DB00958Carboplatin1 / 2Active Not Recruiting1
DB00515Cisplatin1 / 2Active Not Recruiting1
DB00773Etoposide1 / 2Active Not Recruiting1
DB12117Mitometh1 / 2Active Not Recruiting1
DB12191Obatoclax1 / 2Completed1
DB12257Platinum1 / 2Active Not Recruiting1
DB11870RG-47331 / 2Terminated1
DB13017Rovalpituzumab Tesirine1 / 2Completed1
DB01268Sunitinib1 / 2Active Not Recruiting1
DB01030Topotecan1 / 2Completed1
DB019337-Hydroxystaurosporine2Completed1
DB08885Aflibercept2Completed1
DB11595Atezolizumab2Recruiting1
DB06362Becatecarin2Terminated1
DB00958Carboplatin2Completed1
DB00515Cisplatin2Completed1
DB05759Cixutumumab2Completed1
DB12250Cixutumumab2Completed1
DB01254Dasatinib2Completed1
DB00773Etoposide2Completed2
DB05899IT-1012Terminated1
DB00619Imatinib2Completed1
DB05707Isosorbide2Completed1
DB12117Mitometh2Completed1
DB09079Nintedanib2Completed1
DB12257Platinum2Completed1
DB06300Ponatinib2Recruiting1
DB08901Ponatinib2Recruiting1
DB06176Romidepsin2Completed2
DB11805Saracatinib2Completed1
DB00398Sorafenib2Completed1
DB00853Temozolomide2Terminated1
DB01030Topotecan2Completed2
DB01030Topotecan2Terminated1
DB08828Vismodegib2Completed1