Complicated UTI caused by Escherichia coli

Also known as: Complicated Urinary Tract Infection caused by Escherichia Coli

Drugs
Drugs and Targets

Drug	Drug Name	Drug Description
DB00537	Ciprofloxacin	A second generation fluoroquinolone used to treat various susceptible bacterial infections.
DB12107	Vaborbactam	A beta lactamase inhibitor used to treat complicated urinary tract infections.

Drug	Drug Name	Target	Type
DB00537	Ciprofloxacin	DNA gyrase subunit A	target
DB00537	Ciprofloxacin	DNA topoisomerase 4 subunit A	target
DB00537	Ciprofloxacin	DNA topoisomerase 2-alpha	target
DB00537	Ciprofloxacin	Cytochrome P450 1A2	enzyme
DB00537	Ciprofloxacin	Cytochrome P450 3A4	enzyme
DB00537	Ciprofloxacin	Cytochrome P450 3A5	enzyme
DB00537	Ciprofloxacin	Cytochrome P450 3A7	enzyme
DB00537	Ciprofloxacin	P-glycoprotein 1	transporter
DB00537	Ciprofloxacin	Potassium voltage-gated channel subfamily H member 2	target
DB00537	Ciprofloxacin	DNA gyrase subunit A	target
DB00537	Ciprofloxacin	DNA topoisomerase 4 subunit A	target
DB00537	Ciprofloxacin	DNA topoisomerase 4 subunit B	target
DB00537	Ciprofloxacin	DNA gyrase subunit A	target
DB00537	Ciprofloxacin	Multidrug resistance protein MdtK	target
DB00537	Ciprofloxacin	Gyrase A	target
DB00537	Ciprofloxacin	DNA gyrase subunit A	target
DB00537	Ciprofloxacin	Multidrug and toxin extrusion protein 1	transporter
DB00537	Ciprofloxacin	Multidrug and toxin extrusion protein 2	transporter
DB00537	Ciprofloxacin	Serum albumin	carrier
DB12107	Vaborbactam	Beta-lactamase	target
DB12107	Vaborbactam	Carbapenem-hydrolyzing beta-lactamase KPC	target
DB12107	Vaborbactam	Beta-lactamase (KPC-2)	target
DB12107	Vaborbactam	Beta-lactamase CTX-M	target
DB12107	Vaborbactam	Beta-lactamase (blaSHV)	target
DB12107	Vaborbactam	Beta-lactamase SHV-1	target
DB12107	Vaborbactam	Beta-lactamase TEM	target
DB12107	Vaborbactam	Beta-lactamase (MIR-1)	target
DB12107	Vaborbactam	Beta-lactamase	target

Drug	Drug Name	Phase	Status	Count