Letterer-Siwe disease

Also known as: Unifocal Langerhans-cell histiocytosis / Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis / Langerhans cell histiocytosis, disseminated (morphologic abnormality) / Langerhans cell histiocytosis, disseminated (disorder) / Chronic idiopathic xanthomatosis / Langerhans' cell granulomatosis / Langerhans' cell histiocytosis / Langerhans' cell histiocytosis (morphologic abnormality) / Histiocytosis, Langerhans-Cell / Langerhans cell histiocytosis (disorder)

Drugs
Drugs and Targets

Drug	Drug Name	Drug Description
DB00570	Vinblastine	A vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Drug	Drug Name	Target	Type
DB00570	Vinblastine	Tubulin beta chain	target
DB00570	Vinblastine	Transcription factor AP-1	target
DB00570	Vinblastine	Cytochrome P450 3A4	enzyme
DB00570	Vinblastine	P-glycoprotein 1	transporter
DB00570	Vinblastine	Multidrug resistance-associated protein 1	transporter
DB00570	Vinblastine	Canalicular multispecific organic anion transporter 1	transporter
DB00570	Vinblastine	Multidrug resistance-associated protein 6	transporter
DB00570	Vinblastine	Bile salt export pump	transporter
DB00570	Vinblastine	Tubulin alpha-1A chain	target
DB00570	Vinblastine	Tubulin delta chain	target
DB00570	Vinblastine	Tubulin epsilon chain	target
DB00570	Vinblastine	Tubulin gamma-1 chain	target
DB00570	Vinblastine	Cytochrome P450 2D6	enzyme
DB00570	Vinblastine	Solute carrier organic anion transporter family member 1B1	transporter

Drug	Drug Name	Phase	Status	Count