Prophylaxis of preeclampsia

Also known as: Pre-eclampsia / Toxemia of pregnancy / Pre Eclampsia / Unspecified pre-eclampsia, unspecified trimester / Toxaemia of pregnancy / Pre-eclamptic toxaemia / Pre-eclampsia toxaemia / Pre-eclampsia toxemia

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidThe prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
DB00999HydrochlorothiazideA thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
DB00653Magnesium sulfateA small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidSerum albumincarrier
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidSolute carrier family 22 member 7transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C8enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidNuclear factor NF-kappa-Btarget
DB00999HydrochlorothiazideSolute carrier family 12 member 3target
DB00999HydrochlorothiazideCarbonic anhydrase 1target
DB00999HydrochlorothiazideCarbonic anhydrase 2target
DB00999HydrochlorothiazideSolute carrier family 22 member 6transporter
DB00999HydrochlorothiazideCalcium-activated potassium channel subunit alpha-1target
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DrugDrug NamePhaseStatusCount
DB05794Serelaxin1Suspended1
DB00169Cholecalciferol1 / 2Completed1
DB00653Magnesium sulfate1 / 2Completed1
DB01373Calcium2Completed1
DB00076Digoxin Immune Fab (Ovine)2Completed1
DB01275Hydralazine2Completed1
DB00598Labetalol2Completed1
DB00175Pravastatin2Recruiting1
DB00203Sildenafil2Terminated1
DB00633Dexmedetomidine2 / 3Completed1
DB00155L-Citrulline2 / 3Recruiting1
DB04465Lactose2 / 3Recruiting1
DB00945Acetylsalicylic acid3Suspended1
DB01076Atorvastatin3Completed1
DB01373Calcium3Completed1
DB00736Esomeprazole3Recruiting1
DB00999Hydrochlorothiazide3Recruiting1
DB00125L-Arginine3Completed1
DB00653Magnesium sulfate3Completed1
DB00929Misoprostol3Completed1
DB00316Acetaminophen4Active Not Recruiting1
DB00316Acetaminophen4Completed1
DB00945Acetylsalicylic acid4Completed3
DB01364Ephedrine4Recruiting1
DB01050Ibuprofen4Active Not Recruiting1
DB01050Ibuprofen4Completed1
DB00598Labetalol4Recruiting1
DB00968Methyldopa4Recruiting1
DB01115Nifedipine4Recruiting1
DB00388Phenylephrine4Recruiting1
DB00899Remifentanil4Unknown Status1
DB09153Sodium chloride4Unknown Status1
DB01364EphedrineNot AvailableRecruiting1
DB00736EsomeprazoleNot AvailableRecruiting1
DB00653Magnesium sulfateNot AvailableActive Not Recruiting1
DB00653Magnesium sulfateNot AvailableCompleted1
DB00331MetforminNot AvailableRecruiting1
DB00968MethyldopaNot AvailableActive Not Recruiting1
DB01115NifedipineNot AvailableCompleted1
DB00393NimodipineNot AvailableCompleted1
DB00107OxytocinNot AvailableRecruiting1
DB00396ProgesteroneNot AvailableWithdrawn1