Acute attack of hereditary angioedema

Also known as: Acute attacks Hereditary angioedema / Acute attacks of hereditary angioedema / Hereditary angioedema attack / Hereditary angioedema C1 inhibitor deficiency / Hereditary angioedema / Hereditary angioneurotic edema (disorder) / Angioedemas, Hereditary / C1 esterase inhibitor deficiency

Drug	Drug Name	Drug Description
DB15982	Berotralstat	An inhibitor of plasma kallikrein used for prophylaxis of angioedema attacks in patients with hereditary angioedema.
DB09228	Conestat alfa	A recombinant C1INH used for the treatment of acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency in adults.
DB05311	Ecallantide	A kallikrein inhibitor used to prevent and treat acute attacks caused by Hereditary Angioedema (HAE).
DB06404	Human C1-esterase inhibitor	A C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema.
DB06196	Icatibant	A bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE).
DB14597	Lanadelumab	A monoclonal antibody targeted against kallikrein which is used to treat attacks of hereditary angioedema.

Drug	Drug Name	Target	Type
DB15982	Berotralstat	Cytochrome P450 2D6	enzyme
DB15982	Berotralstat	Cytochrome P450 3A4	enzyme
DB15982	Berotralstat	P-glycoprotein 1	transporter
DB15982	Berotralstat	ATP-binding cassette sub-family G member 2	transporter
DB15982	Berotralstat	Plasma kallikrein	target
DB09228	Conestat alfa	Complement C1r subcomponent	target
DB09228	Conestat alfa	Complement C1s subcomponent	target
DB09228	Conestat alfa	Plasma kallikrein	target
DB09228	Conestat alfa	Coagulation factor XII	target
DB09228	Conestat alfa	Prothrombin	target
DB09228	Conestat alfa	Coagulation factor XI	target
DB09228	Conestat alfa	Tissue-type plasminogen activator	target
DB05311	Ecallantide	Plasma kallikrein	target
DB06404	Human C1-esterase inhibitor	Complement C1r subcomponent	target
DB06404	Human C1-esterase inhibitor	Complement C1s subcomponent	target
DB06404	Human C1-esterase inhibitor	Plasma kallikrein	target
DB06404	Human C1-esterase inhibitor	Coagulation factor XII	target
DB06404	Human C1-esterase inhibitor	Prothrombin	target
DB06404	Human C1-esterase inhibitor	Coagulation factor XI	target
DB06404	Human C1-esterase inhibitor	Tissue-type plasminogen activator	target
DB06196	Icatibant	B2 bradykinin receptor	target
DB06196	Icatibant	Aminopeptidase N	target
DB14597	Lanadelumab	Plasma kallikrein	target

Drug	Drug Name	Phase	Status	Count
DB18303	Deucrictibant	2	Active Not Recruiting	1
DB18303	Deucrictibant	2	Completed	1
DB18303	Deucrictibant	2 / 3	Recruiting	1