Seizures

Also known as: Seizure / Convulsions / Convulsion (NOS) / Convulsion / Convulsions NOS / Fit / Fitting / Convulsion disorder / Fits NOS

DrugDrug NameDrug Description
DB01320FosphenytoinFosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
DB00252PhenytoinAn anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
DB00697TizanidineTizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury [T574]. It may also be caused by musculoskeletal injury [A177583]. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition. Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm [FDA label].
DrugDrug NameTargetType
DB01320FosphenytoinSodium channel protein type 5 subunit alphatarget
DB01320FosphenytoinCytochrome P450 2C19enzyme
DB01320FosphenytoinCytochrome P450 2B6enzyme
DB01320FosphenytoinCytochrome P450 2C9enzyme
DB01320FosphenytoinCytochrome P450 3A4enzyme
DB01320FosphenytoinSerum albumincarrier
DB01320FosphenytoinCytochrome P450 1A2enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-6enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-9enzyme
DB01320FosphenytoinCytochrome P450 2D6enzyme
DB01320FosphenytoinThyroxine-binding globulincarrier
DB00252PhenytoinSodium channel protein type 5 subunit alphatarget
DB00252PhenytoinSodium channel protein type 1 subunit alphatarget
DB00252PhenytoinCytochrome P450 2C8enzyme
DB00252PhenytoinCytochrome P450 2C19enzyme
DB00252PhenytoinCytochrome P450 2C9enzyme
DB00252PhenytoinCytochrome P450 2B6enzyme
DB00252PhenytoinCytochrome P450 3A5enzyme
DB00252PhenytoinSerum albumincarrier
DB00252PhenytoinCytochrome P450 3A4enzyme
DB00252PhenytoinSolute carrier organic anion transporter family member 1C1transporter
DB00252PhenytoinMultidrug resistance protein 1transporter
DB00252PhenytoinCanalicular multispecific organic anion transporter 1transporter
DB00252PhenytoinCytochrome P450 11B1, mitochondrialenzyme
DB00252PhenytoinCytochrome P450 2C18enzyme
DB00252PhenytoinCytochrome P450 3A7enzyme
DB00252PhenytoinNuclear receptor subfamily 1 group I member 2target
DB00252PhenytoinSodium channel subunit beta-1target
DB00252PhenytoinSodium channel protein type 3 subunit alphatarget
DB00252PhenytoinUDP-glucuronosyltransferase 1-1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-6enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-9enzyme
DB00252PhenytoinCytochrome P450 2D6enzyme
DB00252PhenytoinThyroxine-binding globulincarrier
DB00697TizanidineAlpha-2 adrenergic receptorstarget
DB00697TizanidineCytochrome P450 1A2enzyme
DB00697TizanidineNischarintarget
DB00697TizanidineAlpha-1 adrenergic receptorstarget
DrugDrug NamePhaseStatusCount
DB00887Bumetanide1Completed1
DB09061Cannabidiol1Active Not Recruiting2
DB01202Levetiracetam1Completed1
DB00683Midazolam1Completed1
DB00776Oxcarbazepine1Completed2
DB06201Rufinamide1Completed1
DB00273Topiramate1Completed1
DB00313Valproic Acid1Completed1
DB09061Cannabidiol1 / 2Completed1
DB00555Lamotrigine1 / 2Completed1
DB01202Levetiracetam1 / 2Completed4
DB00316Acetaminophen2Recruiting1
DB00490Buspirone2Terminated1
DB00349Clobazam2Completed1
DB00829Diazepam2Completed1
DB00254Doxycycline2Recruiting1
DB01050Ibuprofen2Recruiting1
DB01202Levetiracetam2Completed2
DB00683Midazolam2Completed1
DB08883Perampanel2Recruiting1
DB00230Pregabalin2Completed1
DB12646SGS-7422Completed1
DB12367Selurampanel2Completed1
DB00273Topiramate2Completed5
DB00169Cholecalciferol2 / 3Completed1
DB00186Lorazepam2 / 3Withdrawn1
DB09061Cannabidiol3Active Not Recruiting1
DB09061Cannabidiol3Completed1
DB09061Cannabidiol3Enrolling by Invitation1
DB00564Carbamazepine3Completed2
DB12338Carisbamate3Terminated1
DB00349Clobazam3Completed1
DB00829Diazepam3Completed1
DB00593Ethosuximide3Completed1
DB04953Ezogabine3Completed1
DB00996Gabapentin3Completed1
DB00555Lamotrigine3Completed2
DB01202Levetiracetam3Terminated1
DB00186Lorazepam3Completed1
DB00230Pregabalin3Completed1
DB00273Topiramate3Completed10
DB00273Topiramate3Terminated1
DB00313Valproic Acid3Completed2
DB00564Carbamazepine4Completed1
DB04953Ezogabine4Terminated1
DB06218Lacosamide4Terminated1
DB01202Levetiracetam4Recruiting3
DB01202Levetiracetam4Terminated1
DB01202Levetiracetam4Withdrawn1
DB00683Midazolam4Recruiting1
DB00252Phenytoin4Terminated1
DB00252Phenytoin4Unknown Status1
DB00230Pregabalin4Completed1
DB00273Topiramate4Completed2
DB00302Tranexamic acid4Not Yet Recruiting1
DB00313Valproic Acid4Completed1
DB06151AcetylcysteineNot AvailableWithdrawn1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB00559BosentanNot AvailableRecruiting1
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00828FosfomycinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB01221KetamineNot AvailableActive Not Recruiting1
DB00598LabetalolNot AvailableRecruiting1
DB06218LacosamideNot AvailableCompleted1
DB01202LevetiracetamNot AvailableCompleted7
DB01202LevetiracetamNot AvailableWithdrawn1
DB08815LurasidoneNot AvailableRecruiting1
DB14009Medical CannabisNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00776OxcarbazepineNot AvailableCompleted3
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableRecruiting1
DB00684TobramycinNot AvailableRecruiting1
DB00273TopiramateNot AvailableCompleted1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00313Valproic AcidNot AvailableCompleted1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00661VerapamilNot AvailableUnknown Status1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1