Seizures

Also known as: Seizure / Convulsions / Convulsion (NOS) / Convulsion / Convulsions NOS / Fit / Fitting / Convulsion disorder / Fits NOS

DrugDrug NameDrug Description
DB01320FosphenytoinFosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
DB00683MidazolamA short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. [PubChem] Midazolam is a schedule IV drug in the United States.
DB00252PhenytoinAn anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [PubChem]
DB00313Valproic AcidValproic acid, supplied as the sodium salt valproate semisodium or divalproex sodium, is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. Typically supplied in the sodium salt form (CAS number: 76584-70-8). Valproic Acid is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.
DrugDrug NameTargetType
DB01320FosphenytoinSodium channel protein type 5 subunit alphatarget
DB01320FosphenytoinCytochrome P450 2C19enzyme
DB01320FosphenytoinCytochrome P450 2B6enzyme
DB01320FosphenytoinCytochrome P450 2C9enzyme
DB01320FosphenytoinCytochrome P450 3A4enzyme
DB01320FosphenytoinSerum albumincarrier
DB01320FosphenytoinCytochrome P450 1A2enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-6enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-9enzyme
DB01320FosphenytoinCytochrome P450 2D6enzyme
DB00683MidazolamCytochrome P450 3A4enzyme
DB00683MidazolamCytochrome P450 3A5enzyme
DB00683MidazolamCytochrome P450 3A7enzyme
DB00683MidazolamCytochrome P450 2B6enzyme
DB00683MidazolamCytochrome P450 4B1enzyme
DB00683MidazolamUDP-glucuronosyltransferase 1-4enzyme
DB00683MidazolamCytochrome P450 2E1enzyme
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-1target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-2target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-3target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-4target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-5target
DB00683MidazolamGamma-aminobutyric acid receptor subunit beta-1target
DB00683MidazolamGamma-aminobutyric acid receptor subunit beta-3target
DB00683MidazolamGamma-aminobutyric acid receptor subunit beta-2target
DB00683MidazolamGamma-aminobutyric acid receptor subunit alpha-6target
DB00683MidazolamGamma-aminobutyric acid receptor subunit gamma-1target
DB00683MidazolamGamma-aminobutyric acid receptor subunit gamma-2target
DB00683MidazolamGamma-aminobutyric acid receptor subunit gamma-3target
DB00683MidazolamGamma-aminobutyric acid receptor subunit deltatarget
DB00683MidazolamGamma-aminobutyric acid receptor subunit epsilontarget
DB00683MidazolamGamma-aminobutyric acid receptor subunit pitarget
DB00683MidazolamGamma-aminobutyric acid receptor subunit rho-1target
DB00683MidazolamGamma-aminobutyric acid receptor subunit rho-2target
DB00683MidazolamGamma-aminobutyric acid receptor subunit rho-3target
DB00683MidazolamGamma-aminobutyric acid receptor subunit thetatarget
DB00683MidazolamMultidrug resistance protein 1transporter
DB00683MidazolamSolute carrier family 22 member 1transporter
DB00683MidazolamBile salt export pumptransporter
DB00252PhenytoinSodium channel protein type 5 subunit alphatarget
DB00252PhenytoinSodium channel protein type 1 subunit alphatarget
DB00252PhenytoinCytochrome P450 2C8enzyme
DB00252PhenytoinCytochrome P450 2C19enzyme
DB00252PhenytoinCytochrome P450 2C9enzyme
DB00252PhenytoinCytochrome P450 2B6enzyme
DB00252PhenytoinCytochrome P450 3A5enzyme
DB00252PhenytoinSerum albumincarrier
DB00252PhenytoinCytochrome P450 3A4enzyme
DB00252PhenytoinSolute carrier organic anion transporter family member 1C1transporter
DB00252PhenytoinMultidrug resistance protein 1transporter
DB00252PhenytoinCanalicular multispecific organic anion transporter 1transporter
DB00252PhenytoinCytochrome P450 11B1, mitochondrialenzyme
DB00252PhenytoinCytochrome P450 2C18enzyme
DB00252PhenytoinCytochrome P450 3A7enzyme
DB00252PhenytoinNuclear receptor subfamily 1 group I member 2target
DB00252PhenytoinSodium channel subunit beta-1target
DB00252PhenytoinSodium channel protein type 3 subunit alphatarget
DB00252PhenytoinUDP-glucuronosyltransferase 1-1enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-6enzyme
DB00252PhenytoinUDP-glucuronosyltransferase 1-9enzyme
DB00252PhenytoinCytochrome P450 2D6enzyme
DB00313Valproic Acid4-aminobutyrate aminotransferase, mitochondrialtarget
DB00313Valproic AcidHistone deacetylase 9target
DB00313Valproic AcidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00313Valproic AcidCytochrome P450 2A6enzyme
DB00313Valproic AcidCytochrome P450 2B6enzyme
DB00313Valproic AcidCytochrome P450 2C9enzyme
DB00313Valproic AcidSolute carrier family 22 member 5transporter
DB00313Valproic AcidSolute carrier family 22 member 6transporter
DB00313Valproic AcidSolute carrier family 22 member 8transporter
DB00313Valproic AcidMonocarboxylate transporter 1transporter
DB00313Valproic AcidSolute carrier family 22 member 7transporter
DB00313Valproic AcidCytochrome P450 3A5enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-9enzyme
DB00313Valproic AcidProstaglandin G/H synthase 1enzyme
DB00313Valproic AcidCytochrome P450 1A2enzyme
DB00313Valproic AcidCytochrome P450 2C18enzyme
DB00313Valproic AcidCytochrome P450 2C19enzyme
DB00313Valproic AcidCytochrome P450 2C8enzyme
DB00313Valproic AcidCytochrome P450 3A4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-8enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-10enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-6enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-3enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B7enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B15enzyme
DB00313Valproic Acid2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSodium channel proteintarget
DB00313Valproic AcidHistone deacetylase 2target
DB00313Valproic AcidPeroxisome proliferator-activated receptor alphatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor deltatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor gammatarget
DB00313Valproic AcidSerum albumincarrier
DB00313Valproic AcidUDP-glucuronosyltransferase 1-1enzyme
DB00313Valproic AcidSolute carrier organic anion transporter family member 2B1transporter
DrugDrug NamePhaseStatusCount
DB00887Bumetanide1Active Not Recruiting1
DB09061Cannabidiol1Active Not Recruiting1
DB09061Cannabidiol1Recruiting1
DB01202Levetiracetam1Completed1
DB00683Midazolam1Completed1
DB00776Oxcarbazepine1Completed2
DB06201Rufinamide1Completed1
DB00273Topiramate1Completed1
DB00313Valproic Acid1Completed1
DB09061Cannabidiol1 / 2Completed1
DB00555Lamotrigine1 / 2Completed1
DB01202Levetiracetam1 / 2Completed4
DB00316Acetaminophen2Recruiting1
DB00490Buspirone2Terminated1
DB00349Clobazam2Completed1
DB00829Diazepam2Completed1
DB00254Doxycycline2Recruiting1
DB01050Ibuprofen2Recruiting1
DB01202Levetiracetam2Completed2
DB00683Midazolam2Completed1
DB00230Pregabalin2Completed1
DB12646SGS-7422Active Not Recruiting1
DB12367Selurampanel2Completed1
DB00273Topiramate2Completed5
DB00169Cholecalciferol2 / 3Active Not Recruiting1
DB00186Lorazepam2 / 3Withdrawn1
DB09061Cannabidiol3Active Not Recruiting1
DB09061Cannabidiol3Completed1
DB09061Cannabidiol3Enrolling by Invitation1
DB00564Carbamazepine3Completed2
DB12338Carisbamate3Terminated1
DB00349Clobazam3Completed1
DB00829Diazepam3Completed1
DB00593Ethosuximide3Completed1
DB04953Ezogabine3Completed1
DB00996Gabapentin3Completed1
DB00555Lamotrigine3Completed2
DB01202Levetiracetam3Terminated1
DB00186Lorazepam3Completed1
DB00230Pregabalin3Completed1
DB00273Topiramate3Completed10
DB00273Topiramate3Terminated1
DB00313Valproic Acid3Completed2
DB00564Carbamazepine4Completed1
DB04953Ezogabine4Terminated1
DB06218Lacosamide4Terminated1
DB01202Levetiracetam4Recruiting3
DB01202Levetiracetam4Terminated1
DB01202Levetiracetam4Withdrawn1
DB00683Midazolam4Recruiting1
DB00252Phenytoin4Terminated1
DB00252Phenytoin4Unknown Status1
DB00230Pregabalin4Completed1
DB00273Topiramate4Completed2
DB00313Valproic Acid4Completed1
DB06151AcetylcysteineNot AvailableWithdrawn1
DB00802AlfentanilNot AvailableRecruiting1
DB01238AripiprazoleNot AvailableRecruiting1
DB00438CeftazidimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB00829DiazepamNot AvailableRecruiting1
DB01320FosphenytoinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB01109HeparinNot AvailableRecruiting1
DB00327HydromorphoneNot AvailableRecruiting1
DB01221KetamineNot AvailableActive Not Recruiting1
DB06218LacosamideNot AvailableCompleted1
DB01202LevetiracetamNot AvailableCompleted7
DB01202LevetiracetamNot AvailableRecruiting1
DB01202LevetiracetamNot AvailableWithdrawn1
DB08815LurasidoneNot AvailableRecruiting1
DB00760MeropenemNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00683MidazolamNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00295MorphineNot AvailableRecruiting1
DB00622NicardipineNot AvailableRecruiting1
DB00334OlanzapineNot AvailableRecruiting1
DB00198OseltamivirNot AvailableRecruiting1
DB00776OxcarbazepineNot AvailableCompleted3
DB00312PentobarbitalNot AvailableRecruiting1
DB00818PropofolNot AvailableRecruiting1
DB01224QuetiapineNot AvailableRecruiting1
DB00734RisperidoneNot AvailableRecruiting1
DB00373TimololNot AvailableRecruiting1
DB00684TobramycinNot AvailableRecruiting1
DB00273TopiramateNot AvailableCompleted1
DB00273TopiramateNot AvailableRecruiting1
DB00313Valproic AcidNot AvailableCompleted1
DB00313Valproic AcidNot AvailableRecruiting1
DB00661VerapamilNot AvailableUnknown Status1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1