Itching

Also known as: ITCH / Pruritus / Pruritus NOS / Pruritis / Unspecified pruritic disorder / Pruritus cutaneous / Itchy skin / Itchy

DrugDrug NameDrug Description
DB04890BepotastineBepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name Talion. It is available in oral and opthalmic dosage forms in Japan. The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve.
DB00196FluconazoleFluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.[A174325]
DB14539Hydrocortisone acetateNot Available
DB14543Hydrocortisone probutateNot Available
DB14156Synthetic camphorNot Available
DB14487Zinc acetateNot Available
DrugDrug NameTargetType
DB04890BepotastineHistamine H1 receptortarget
DB00196FluconazoleCytochrome P450 3A4enzyme
DB00196FluconazoleCytochrome P450 2C9enzyme
DB00196FluconazoleCytochrome P450 2C19enzyme
DB00196FluconazoleMultidrug resistance protein 1transporter
DB00196FluconazoleLanosterol 14-alpha demethylasetarget
DB00196FluconazoleCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateAnnexin A1target
DB14539Hydrocortisone acetateGlucocorticoid receptortarget
DB14539Hydrocortisone acetateSex hormone-binding globulincarrier
DB14539Hydrocortisone acetateCytochrome P450 3A4enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A7enzyme
DB14539Hydrocortisone acetateMultidrug resistance protein 1transporter
DB14539Hydrocortisone acetateSolute carrier organic anion transporter family member 1A2transporter
DB14539Hydrocortisone acetateATP-binding cassette sub-family G member 2transporter
DB14539Hydrocortisone acetateCytochrome P450 11B1, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 11B2, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 2C8enzyme
DB14539Hydrocortisone acetateCorticosteroid-binding globulincarrier
DB14539Hydrocortisone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14539Hydrocortisone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14539Hydrocortisone acetateSolute carrier family 22 member 8transporter
DB14543Hydrocortisone probutateAnnexin A1target
DB14543Hydrocortisone probutateGlucocorticoid receptortarget
DB14543Hydrocortisone probutateSex hormone-binding globulincarrier
DB14543Hydrocortisone probutateCytochrome P450 3A4enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A5enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A7enzyme
DB14543Hydrocortisone probutateMultidrug resistance protein 1transporter
DB14543Hydrocortisone probutateSolute carrier organic anion transporter family member 1A2transporter
DB14543Hydrocortisone probutateATP-binding cassette sub-family G member 2transporter
DB14543Hydrocortisone probutateCytochrome P450 11B1, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 11B2, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 2C8enzyme
DB14543Hydrocortisone probutateCorticosteroid-binding globulincarrier
DB14543Hydrocortisone probutateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14543Hydrocortisone probutate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14543Hydrocortisone probutateSolute carrier family 22 member 8transporter
DB14487Zinc acetateB1 bradykinin receptortarget
DB14487Zinc acetateMethylated-DNA--protein-cysteine methyltransferasetarget
DB14487Zinc acetateFructose-bisphosphate aldolase Atarget
DB14487Zinc acetateElongation factor 1-alpha 1target
DB14487Zinc acetateAlpha-enolasetarget
DB14487Zinc acetateGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB14487Zinc acetateNucleoside diphosphate kinase Atarget
DB14487Zinc acetateProtein disulfide-isomerasetarget
DB14487Zinc acetateProtein disulfide-isomerase A3target
DB14487Zinc acetatePeroxiredoxin-1target
DB14487Zinc acetatePhosphoserine phosphatasetarget
DB14487Zinc acetateTriosephosphate isomerasetarget
DB14487Zinc acetateElongation factor Tu, mitochondrialtarget
DB14487Zinc acetateEstrogen receptor alphatarget
DB14487Zinc acetateInterleukin-3target
DB14487Zinc acetateMetallothionein-2target
DB14487Zinc acetateCopper chaperone for superoxide dismutasetarget
DB14487Zinc acetateHistone deacetylase 1target
DB14487Zinc acetateHistone deacetylase 4target
DB14487Zinc acetateDNA-3-methyladenine glycosylasetarget
DB14487Zinc acetateSemenogelin-1target
DB14487Zinc acetateSuperoxide dismutase [Cu-Zn]target
DB14487Zinc acetateHistone deacetylase 8target
DB14487Zinc acetateApoptosis regulatory protein Sivatarget
DB14487Zinc acetateGlycine receptor subunit alpha-1target
DB14487Zinc acetateE3 ubiquitin-protein ligase Mdm2target
DB14487Zinc acetateInsulintarget
DB14487Zinc acetateUtrophintarget
DB14487Zinc acetateAspartoacylasetarget
DB14487Zinc acetateProtein S100-A8target
DB14487Zinc acetateProtein S100-A9target
DB14487Zinc acetateMatrix metalloproteinase-9target
DB14487Zinc acetateTumor protein p73target
DB14487Zinc acetateProtein S100-A2target
DB14487Zinc acetateCellular tumor antigen p53target
DB14487Zinc acetateMetallothionein-3target
DB14487Zinc acetateProgrammed cell death protein 6target
DB14487Zinc acetateDAN domain family member 5target
DB14487Zinc acetateMetallothionein-1Atarget
DB14487Zinc acetateAlpha-1B-glycoproteintarget
DB14487Zinc acetateAlpha-2-macroglobulintarget
DB14487Zinc acetateAngiotensinogentarget
DB14487Zinc acetateAlpha-2-HS-glycoproteintarget
DB14487Zinc acetateSerum amyloid P-componenttarget
DB14487Zinc acetateApolipoprotein A-Itarget
DB14487Zinc acetateApolipoprotein A-IItarget
DB14487Zinc acetateApolipoprotein A-IVtarget
DB14487Zinc acetateApolipoprotein B receptortarget
DB14487Zinc acetateApolipoprotein Etarget
DB14487Zinc acetateApolipoprotein L1target
DB14487Zinc acetateComplement C1q subcomponent subunit Btarget
DB14487Zinc acetateComplement C1q subcomponent subunit Ctarget
DB14487Zinc acetateComplement C1r subcomponenttarget
DB14487Zinc acetateComplement C1s subcomponenttarget
DB14487Zinc acetateComplement C3target
DB14487Zinc acetateComplement C4-Btarget
DB14487Zinc acetateC4b-binding protein alpha chaintarget
DB14487Zinc acetateC4b-binding protein beta chaintarget
DB14487Zinc acetateComplement C5target
DB14487Zinc acetateLys-63-specific deubiquitinase BRCC36target
DB14487Zinc acetateComplement component C8 alpha chaintarget
DB14487Zinc acetateComplement component C8 beta chaintarget
DB14487Zinc acetateComplement component C8 gamma chaintarget
DB14487Zinc acetateComplement factor Btarget
DB14487Zinc acetateComplement factor Htarget
DB14487Zinc acetateComplement factor Itarget
DB14487Zinc acetateClusterintarget
DB14487Zinc acetateCeruloplasmintarget
DB14487Zinc acetateCarboxypeptidase N catalytic chaintarget
DB14487Zinc acetateCarboxypeptidase N subunit 2target
DB14487Zinc acetateDermcidintarget
DB14487Zinc acetateDesmoplakintarget
DB14487Zinc acetateCoagulation factor XIItarget
DB14487Zinc acetateCoagulation factor XIII B chaintarget
DB14487Zinc acetateProthrombintarget
DB14487Zinc acetateFicolin-3target
DB14487Zinc acetateFibrinogen alpha chaintarget
DB14487Zinc acetateFibronectintarget
DB14487Zinc acetateGelsolintarget
DB14487Zinc acetateHemoglobin subunit alphatarget
DB14487Zinc acetateHemoglobin subunit betatarget
DB14487Zinc acetateHaptoglobin-related proteintarget
DB14487Zinc acetateHornerintarget
DB14487Zinc acetateInsulin-like growth factor-binding protein complex acid labile subunittarget
DB14487Zinc acetateIg alpha-1 chain C regiontarget
DB14487Zinc acetateIg mu chain C regiontarget
DB14487Zinc acetateImmunoglobulin kappa variable 1-17target
DB14487Zinc acetateIg kappa chain V-III region GOLtarget
DB14487Zinc acetateImmunoglobulin lambda variable 3-21target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H1target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H2target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H3target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H4target
DB14487Zinc acetateImmunoglobulin J chaintarget
DB14487Zinc acetateJunction plakoglobintarget
DB14487Zinc acetatePlasma kallikreintarget
DB14487Zinc acetateKininogen-1target
DB14487Zinc acetateKeratin, type II cytoskeletal 1target
DB14487Zinc acetateKeratin, type I cytoskeletal 10target
DB14487Zinc acetateKeratin, type I cytoskeletal 14target
DB14487Zinc acetateKeratin, type I cytoskeletal 16target
DB14487Zinc acetateKeratin, type II cytoskeletal 2 epidermaltarget
DB14487Zinc acetateKeratin, type II cytoskeletal 5target
DB14487Zinc acetateKeratin, type II cytoskeletal 6Atarget
DB14487Zinc acetateKeratin, type I cytoskeletal 9target
DB14487Zinc acetateAlpha-1-acid glycoprotein 2target
DB14487Zinc acetateN-acetylmuramoyl-L-alanine amidasetarget
DB14487Zinc acetateSerum paraoxonase/arylesterase 1target
DB14487Zinc acetatePregnancy zone proteintarget
DB14487Zinc acetateProtein S100-A7target
DB14487Zinc acetateSelenoprotein Ptarget
DB14487Zinc acetateAlpha-1-antitrypsintarget
DB14487Zinc acetateAlpha-1-antichymotrypsintarget
DB14487Zinc acetateKallistatintarget
DB14487Zinc acetateCorticosteroid-binding globulintarget
DB14487Zinc acetateHeparin cofactor 2target
DB14487Zinc acetateSex hormone-binding globulintarget
DB14487Zinc acetateSerotransferrintarget
DB14487Zinc acetateTransthyretintarget
DB14487Zinc acetateVitronectintarget
DB14487Zinc acetateAmyloid-like protein 1target
DB14487Zinc acetateAmyloid-like protein 2target
DB14487Zinc acetateAmyloid beta A4 proteintarget
DB14487Zinc acetatePoly [ADP-ribose] polymerase 1target
DB14487Zinc acetateCarbonic anhydrase 1enzyme
DB14487Zinc acetateCarboxypeptidase Eenzyme
DB14487Zinc acetateAlcohol dehydrogenase 1Cenzyme
DB14487Zinc acetateInsulin-degrading enzymeenzyme
DB14487Zinc acetateSuperoxide dismutase [Cu-Zn]enzyme
DrugDrug NamePhaseStatusCount
DB00240Alclometasone2Completed1
DB05676Apremilast2Active Not Recruiting1
DB00673Aprepitant2Completed1
DB00950Fexofenadine2Completed1
DB06717Fosaprepitant2Completed1
DB00635Prednisone2Completed1
DB00996Gabapentin3Completed1
DB00764Mometasone3Unknown Status1
DB01075DiphenhydramineNot AvailableCompleted1
DB01142DoxepinNot AvailableNot Yet Recruiting1
DB00724ImiquimodNot AvailableNot Yet Recruiting1
DB00281LidocaineNot AvailableRecruiting1
DB00904OndansetronNot AvailableCompleted1