Upper respiratory tract hypersensitivity reaction, site unspecified

Also known as: Upper respiratory allergies / Allergy / Hypersensitivity NOS / Hypersensitivity reaction / Allergy NOS / Hypersensitivity reaction (NOS) / Reaction hypersensitivity (NOS) / Allergic reaction / Hypersensitivity / Allergic reaction NOS / Reaction allergic (NOS) / Allergic reaction (NOS) / HYSN / Hypersensitivity symptom

DrugDrug NameDrug Description
DB00341CetirizineA potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. [PubChem]
DB00405DexbrompheniramineDexbrompheniramine maleate is an antihistamine used to treat allergic conditions such as hay fever or urticaria.
DB01075DiphenhydramineDiphenhydramine, also known commercially as Benadryl, is a first generation antihistamine that is used primarily for the treatment of seasonal allergies. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system. While its use in in allergies has largely fallen out of favour due to this sedative effect, diphenhydramine has been repurposed for use within many OTC (over the counter) cough-and-cold medications that have been marketed for "night time" use. Diphenhydramine is also used in combination with [DB14132] as the anti-nausea drug [DB00985] where it is utilized primarily for its antagonism of H1 histamine receptors within the vestibular system [A1540]. Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid [A1539]. As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
DrugDrug NamePhaseStatusCount