Also known as: Refractory Non Hodgkin Lymphoma / Refractory Non-Hodgkin Lymphoma / Refractory Non-Hodgkin's lymphoma / Refractory Non-Hodgkin Lympoma / Refractory Non-Hodgkin-Lymphoma / Non-Hodgkin's lymphoma refractory / Non-Hodgkin's lymphoma NOS refractory
DrugDrug NameDrug Description
DB00958CarboplatinAn organoplatinum compound that possesses antineoplastic activity. [PubChem]
DB00262CarmustineA cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
DB00515CisplatinCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
DB01073FludarabineFludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. [Wikipedia]
DB00526OxaliplatinOxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. It is typically administered in combination with fluorouracil and leucovorin in a combination known as Folfox for the treatment of colorectal cancer. Compared to cisplatin the two amine groups are replaced by cyclohexyldiamine for improved antitumour activity. The chlorine ligands are replaced by the oxalato bidentate derived from oxalic acid in order to improve water solubility. Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin®.
DrugDrug NameTargetType
DB00958CarboplatinDNAtarget
DB00958CarboplatinHigh affinity copper uptake protein 1transporter
DB00958CarboplatinProbable low affinity copper uptake protein 2transporter
DB00958CarboplatinXanthine dehydrogenase/oxidaseenzyme
DB00958CarboplatinMyeloperoxidaseenzyme
DB00958CarboplatinGlutathione S-transferase theta-1enzyme
DB00958CarboplatinMetallothionein-1Aenzyme
DB00958CarboplatinMetallothionein-2enzyme
DB00958CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00958CarboplatinGlutathione S-transferase Penzyme
DB00958CarboplatinGlutathione S-transferase Mu 1enzyme
DB00958CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00958CarboplatinCopper-transporting ATPase 1transporter
DB00958CarboplatinCopper-transporting ATPase 2transporter
DB00958CarboplatinATP-binding cassette sub-family G member 2transporter
DB00958CarboplatinCanalicular multispecific organic anion transporter 1transporter
DB00262CarmustineGlutathione reductase, mitochondrialtarget
DB00262CarmustineDNAtarget
DB00262CarmustineCytochrome P450 1A2enzyme
DB00262CarmustineRNAtarget
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB01073FludarabineDNA polymerase alpha catalytic subunittarget
DB01073FludarabineRibonucleoside-diphosphate reductase large subunittarget
DB01073FludarabineEquilibrative nucleoside transporter 1transporter
DB01073FludarabineDNAtarget
DB01073FludarabineDeoxycytidine kinasetarget
DB01073FludarabineSolute carrier family 28 member 3transporter
DB00526OxaliplatinDNAtarget
DB00526OxaliplatinSolute carrier family 22 member 2transporter
DB00526OxaliplatinSolute carrier family 22 member 1transporter
DB00526OxaliplatinHigh affinity copper uptake protein 1transporter
DB00526OxaliplatinSolute carrier family 22 member 3transporter
DB00526OxaliplatinATP-binding cassette sub-family G member 2transporter
DB00526OxaliplatinCytochrome P450 1A1enzyme
DB00526OxaliplatinCytochrome P450 1A2enzyme
DB00526OxaliplatinCytochrome P450 1B1enzyme
DB00526OxaliplatinCytochrome P450 2E1enzyme
DB00526OxaliplatinGlutathione S-transferase theta-1enzyme
DB00526OxaliplatinMetallothionein-1Aenzyme
DB00526OxaliplatinMetallothionein-2enzyme
DB00526OxaliplatinMyeloperoxidaseenzyme
DB00526OxaliplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00526OxaliplatinGlutathione S-transferase Penzyme
DB00526OxaliplatinGlutathione S-transferase Mu 1enzyme
DB00526OxaliplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00526OxaliplatinCanalicular multispecific organic anion transporter 1transporter
DB00526OxaliplatinCopper-transporting ATPase 2transporter
DB00526OxaliplatinCopper-transporting ATPase 1transporter
DrugDrug NamePhaseStatusCount
DB00262Carmustine1 / 2Active Not Recruiting1
DB00493Cefotaxime1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Active Not Recruiting1
DB00091Cyclosporine1 / 2Active Not Recruiting1
DB00987Cytarabine1 / 2Active Not Recruiting1
DB00773Etoposide1 / 2Active Not Recruiting1
DB01073Fludarabine1 / 2Active Not Recruiting1
DB06186Ipilimumab1 / 2Recruiting1
DB01042Melphalan1 / 2Active Not Recruiting1
DB00688Mycophenolate mofetil1 / 2Active Not Recruiting1
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting1
DB00877Sirolimus1 / 2Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting1
DB00262Carmustine2Recruiting1
DB00493Cefotaxime2Recruiting1
DB00531Cyclophosphamide2Recruiting1
DB00091Cyclosporine2Recruiting1
DB00987Cytarabine2Recruiting1
DB12147Erdafitinib2Not Yet Recruiting1
DB00773Etoposide2Recruiting1
DB01073Fludarabine2Recruiting1
DB00078Ibritumomab tiuxetan2Completed1
DB00078Ibritumomab tiuxetan2Recruiting1
DB12167LY-30234142Recruiting1
DB01042Melphalan2Recruiting1
DB00688Mycophenolate mofetil2Recruiting2
DB09074Olaparib2Recruiting1
DB00073Rituximab2Recruiting1
DB11689Selumetinib2Recruiting1
DB00864Tacrolimus2Recruiting1
DB12887Tazemetostat2Recruiting1
DB08881Vemurafenib2Recruiting1
DB13104X-3962Recruiting1
DB08870Brentuximab vedotinNot AvailableActive Not Recruiting1
DB00493CefotaximeNot AvailableRecruiting1
DB00531CyclophosphamideNot AvailableRecruiting1
DB00091CyclosporineNot AvailableRecruiting1
DB01073FludarabineNot AvailableRecruiting1
DB00688Mycophenolate mofetilNot AvailableRecruiting1