Neutropenias

Also known as: Neutropenia

DrugDrug NameDrug Description
DB00787AcyclovirA guanosine analog antiviral drug that acts as an antimetabolite. Aciclovir is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles). Aciclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. Currently approved drugs for the treatment of herpes labialis (cold sores) exhibit low levels of efficacy due to the limited ability of the drugs to penetrate the skin to the site where the herpes virus is replicating. Iontophoresis uses electric current to enhance the delivery of drugs through the skin.
DB00099FilgrastimChemotherapy-induced neutropenia (CIN) is a common and serious complication of myelosuppressive chemotherapy. It is associated with significant morbidity and mortality and can increase the cost of cancer therapy. In these cases, colony stimulating factor is necessary to restore important cells for immune function [A35591]. For over twenty years, granulocyte colony-stimulating factors (G-CSFs; filgrastims) have been a pillar of treatment and prevention of CIN, and have been found to reduce the risk of neutropenia across various patient settings, decrease the incidence of febrile neutropenia, reduce the incidence of infection, reduce the requirement for treatment with antibiotics, and accelerate neutrophil recovery [A35591]. Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analog. It is marketed as the brand name _Neupogen_ by Amgen (initially approved in 1998) and as _Nivestym_, a biosimilar agent by Pfizer. Nivestym was approved by the FDA on July 20th, 2018 [L3735]. Between 1998 and the present, Neupogen/filgrastim has been approved for various indications [L3744]. _Tbo-filgrastim_, which is marketed by Sicor Biotech and FDA approved on August 29, 2012, contains the same active ingredient as Neupogen and is biologically similar, but it is formulated to be short-acting [F719]. On March 6, 2015, the FDA approved the biosimilar Zarxio (filgrastim-sndz) and is indicated for use in the same conditions as Neupogen. Zarxio is marketed by Sandoz [L3742].
DB13200LipegfilgrastimLipegfilgrastim, previously known as XM22, is a pegylated, recombinant granulocyte colony-stimulating factor (G-CSF) that was synthetized using a highly site-specific glycoPEGylation technology [A32665]. It is used as an alternate to [DB00019] for prophylactic use in cancer patients receiving chemotherapy and at risk for developing chemotherapy-induced neutropenia. Since July 2013, lipegfilgrastim is marketed by the EMA as Lonquex for subcutaneously injection, where it is administered once following cytotoxic chemotherapy for each chemotherapy cycle in adult patients being treated with cytotoxic chemotherapy for malignancy. It aims to reduce the duration of neutropenia and the incidence of febrile neutropenia. Neutropenia and febrile neutropenia (FN) are frequent and potentially fatal complications that occur from myelosuppressive anticancer treatments [A32665]. Severe chemotherapy-induced neutropenia and febrile neutropenia significantly increases the risk for life-threatening infection and sepsis. Granulocyte colony-stimulating factors (G-CSFs) were introduced in the 1980's to the clinical setting to stimulate neutrophil proliferation and differentiation, thereby reducing the duration and severity of chemotherapy-induced neutropenia [A32665]. Lipegfilgrastim is a covalent conjugate of [DB00099] with a single methoxy polyethylene glycol (PEG) molecule via a carbohydrate linker consisting of glycine, N-acetylneuraminic acid and N-acetylgalactosamine [L2441]. The average molecular mass of lipegfilgrastim comprises 18,798 Da for [DB00099], 203 Da for GalNAc, 338 Da for glycylsialic acid and approximately 20,000 Da for PEG [L2449]. PEG moiety protects the active molecule from enzyme degradation, which allows longer half-life of drug and less frequent dosing-schedule in addition to acceptable safety and efficacy profile [A32665].
DB01263PosaconazolePosaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
DB00020SargramostimSargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
DB00582VoriconazoleVoriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections.
DrugDrug NameTargetType
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB00099FilgrastimGranulocyte colony-stimulating factor receptortarget
DB00099FilgrastimNeutrophil elastasetarget
DB13200LipegfilgrastimGranulocyte colony-stimulating factor receptortarget
DB01263PosaconazoleCytochrome P450 3A4enzyme
DB01263PosaconazoleMultidrug resistance protein 1transporter
DB01263PosaconazoleLanosterol 14-alpha demethylasetarget
DB00020SargramostimGranulocyte-macrophage colony-stimulating factor receptor subunit alphatarget
DB00020SargramostimBone marrow proteoglycantarget
DB00020SargramostimInterleukin-3 receptor subunit alphatarget
DB00020SargramostimCytokine receptor common subunit betatarget
DB00020SargramostimSyndecan-2target
DB00582VoriconazoleCytochrome P450 2C19enzyme
DB00582VoriconazoleCytochrome P450 3A4enzyme
DB00582VoriconazoleCytochrome P450 2C9enzyme
DB00582VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00582VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00582VoriconazoleCytochrome P450 3A5enzyme
DB00582VoriconazoleCytochrome P450 3A7enzyme
DB00582VoriconazoleProstaglandin G/H synthase 1enzyme
DB00582VoriconazoleLanosterol 14-alpha demethylasetarget
DB00582VoriconazoleCytochrome P450 2B6enzyme
DrugDrug NamePhaseStatusCount
DB00958Carboplatin1Completed2
DB01413Cefepime1Completed1
DB00091Ciclosporin1Completed2
DB00631Clofarabine1Completed1
DB01248Docetaxel1Completed1
DB00445Epirubicin1Completed1
DB00016Erythropoietin1Terminated1
DB00099Filgrastim1Completed3
DB00099Filgrastim1Terminated1
DB00544Fluorouracil1Completed1
DB00762Irinotecan1Completed1
DB04845Ixabepilone1Completed1
DB00480Lenalidomide1Completed1
DB00650Leucovorin1Completed1
DB00526Oxaliplatin1Completed1
DB01229Paclitaxel1Completed1
DB00019Pegfilgrastim1Completed3
DB00019Pegfilgrastim1Unknown Status1
DB01174Phenobarbital1Completed1
DB06809Plerixafor1Completed1
DB01263Posaconazole1Completed1
DB00020Sargramostim1Terminated1
DB01030Topotecan1Completed1
DB05237rhMBL1Withdrawn1
DB00362Anidulafungin1 / 2Completed2
DB00091Ciclosporin1 / 2Completed1
DB00531Cyclophosphamide1 / 2Completed3
DB00445Epirubicin1 / 2Completed1
DB01073Fludarabine1 / 2Completed1
DB00582Voriconazole1 / 2Completed1
DB01143Amifostine2Completed1
DB01143Amifostine2Unknown Status1
DB00681Amphotericin B2Completed1
DB11720Angiotensin 1-72Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB00023Asparaginase Escherichia coli2Completed1
DB00520Caspofungin2Completed1
DB00091Ciclosporin2Completed2
DB00515Cisplatin2Completed2
DB00531Cyclophosphamide2Completed3
DB00987Cytarabine2Completed4
DB00987Cytarabine2Unknown Status1
DB00080Daptomycin2Completed1
DB00012Darbepoetin alfa2Completed1
DB00694Daunorubicin2Completed2
DB01262Decitabine2Completed1
DB01234Dexamethasone2Completed1
DB01248Docetaxel2Completed2
DB00997Doxorubicin2Completed3
DB00773Etoposide2Completed4
DB00099Filgrastim2Completed9
DB09560Filgrastim2Completed1
DB00099Filgrastim2Recruiting2
DB01177Idarubicin2Completed1
DB01181Ifosfamide2Completed1
DB01167Itraconazole2Completed1
DB00650Leucovorin2Completed1
DB00825Levomenthol2Completed1
DB01033Mercaptopurine2Completed1
DB00563Methotrexate2Completed1
DB00959Methylprednisolone2Completed1
DB01141Micafungin2Unknown Status1
DB01204Mitoxantrone2Unknown Status1
DB00019Pegfilgrastim2Completed7
DB00019Pegfilgrastim2Recruiting2
DB00635Prednisone2Completed1
DB10415Rabbit2Completed1
DB00352Tioguanine2Completed1
DB01030Topotecan2Completed1
DB00541Vincristine2Completed2
DB00582Voriconazole2Completed1
DB01060Amoxicillin3Terminated1
DB00681Amphotericin B3Completed1
DB00276Amsacrine3Completed1
DB00276Amsacrine3Unknown Status1
DB00362Anidulafungin3Terminated1
DB00112Bevacizumab3Completed1
DB00262Carmustine3Completed1
DB00520Caspofungin3Completed1
DB00520Caspofungin3Terminated1
DB01413Cefepime3Unknown Status1
DB14733Ceftobiprole medocaril3Terminated1
DB00537Ciprofloxacin3Terminated1
DB00537Ciprofloxacin3Unknown Status1
DB00531Cyclophosphamide3Recruiting1
DB00531Cyclophosphamide3Unknown Status1
DB00987Cytarabine3Completed1
DB00987Cytarabine3Unknown Status1
DB00694Daunorubicin3Unknown Status1
DB01234Dexamethasone3Completed1
DB01248Docetaxel3Recruiting1
DB00898Ethanol3Completed1
DB00773Etoposide3Completed1
DB00773Etoposide3Unknown Status1
DB00099Filgrastim3Completed4
DB00099Filgrastim3Unknown Status1
DB00196Fluconazole3Completed1
DB01177Idarubicin3Completed1
DB01177Idarubicin3Unknown Status1
DB01137Levofloxacin3Completed1
DB01137Levofloxacin3Unknown Status1
DB01204Mitoxantrone3Completed1
DB01204Mitoxantrone3Unknown Status1
DB00019Pegfilgrastim3Active Not Recruiting2
DB00019Pegfilgrastim3Completed2
DB00019Pegfilgrastim3Not Yet Recruiting1
DB00019Pegfilgrastim3Recruiting2
DB06809Plerixafor3Active Not Recruiting1
DB01263Posaconazole3Completed1
DB00352Tioguanine3Unknown Status1
DB00755Tretinoin3Unknown Status1
DB00582Voriconazole3Completed1
DB00016Erythropoietin4Terminated1
DB00099Filgrastim4Unknown Status1
DB01167Itraconazole4Completed3
DB01141Micafungin4Unknown Status1
DB00019Pegfilgrastim4Completed1
DB00019Pegfilgrastim4Unknown Status1
DB01263Posaconazole4Completed1
DB01015Sulfamethoxazole4Completed1
DB00440Trimethoprim4Completed1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableCompleted1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB00559BosentanNot AvailableRecruiting1
DB01008BusulfanNot AvailableCompleted1
DB00520CaspofunginNot AvailableCompleted1
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableTerminated1
DB01147CloxacillinNot AvailableCompleted1
DB00363ClozapineNot AvailableRecruiting1
DB00531CyclophosphamideNot AvailableCompleted1
DB00080DaptomycinNot AvailableWithdrawn1
DB00828FosfomycinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB01598ImipenemNot AvailableCompleted1
DB00598LabetalolNot AvailableRecruiting1
DB13144LenograstimNot AvailableRecruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00218MoxifloxacinNot AvailableTerminated1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00319PiperacillinNot AvailableCompleted1
DB00319PiperacillinNot AvailableUnknown Status1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableRecruiting1
DB01606TazobactamNot AvailableCompleted1
DB01606TazobactamNot AvailableUnknown Status1
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1
DB00512VancomycinNot AvailableWithdrawn1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1