Headaches
all indicationsAlso known as: Headache / Cephalgia / Cephalalgia / Headaches / Head Pain / [D]Headache / Headache NOS / Pain head / Facial pain NOS
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB00945 | Acetylsalicylic acid | The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) |
| DB06681 | Belatacept | Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. It is produced through recombinant DNA technology in mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes. It is approved for the treatment of rheumatoid arthritis. Belatacept selectively blocks the process of T-cell activation. It was developed by Bristol-Myers-Squibb. It differs from abatacept (Orencia) by only 2 amino acids. FDA approved on June 15, 2011. |
| DB00083 | Botulinum Toxin Type A | Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation. |
| DB01050 | Ibuprofen | Ibuprofen, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. |
| DB09054 | Idelalisib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies. More specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils. By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and adhesion, and reduced cell viability. |
| DB00788 | Naproxen | An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. |
| Drug | Drug Name | Phase | Status | Count |
|---|---|---|---|---|
| DB01240 | Epoprostenol | 1 | Terminated | 1 |
| DB00457 | Prazosin | 1 / 2 | Recruiting | 1 |
| DB09153 | Sodium Chloride | 1 / 2 | Completed | 1 |
| DB09145 | Water | 1 / 2 | Completed | 1 |
| DB00297 | Bupivacaine | 2 | Completed | 1 |
| DB09157 | Carbon dioxide | 2 | Completed | 1 |
| DB00633 | Dexmedetomidine | 2 | Completed | 1 |
| DB12158 | Filorexant | 2 | Completed | 1 |
| DB00273 | Topiramate | 2 | Completed | 1 |
| DB00653 | Magnesium Sulfate | 2 / 3 | Withdrawn | 1 |
| DB01233 | Metoclopramide | 2 / 3 | Withdrawn | 1 |
| DB00316 | Acetaminophen | 3 | Terminated | 1 |
| DB00945 | Acetylsalicylic acid | 3 | Terminated | 1 |
| DB00321 | Amitriptyline | 3 | Terminated | 1 |
| DB00321 | Amitriptyline | 3 | Unknown Status | 1 |
| DB00083 | Botulinum Toxin Type A | 3 | Completed | 1 |
| DB00297 | Bupivacaine | 3 | Completed | 1 |
| DB00201 | Caffeine | 3 | Unknown Status | 1 |
| DB01234 | Dexamethasone | 3 | Recruiting | 1 |
| DB01234 | Dexamethasone | 3 | Terminated | 1 |
| DB01075 | Diphenhydramine | 3 | Recruiting | 1 |
| DB01050 | Ibuprofen | 3 | Unknown Status | 1 |
| DB01221 | Ketamine | 3 | Recruiting | 1 |
| DB01221 | Ketamine | 3 | Terminated | 1 |
| DB00465 | Ketorolac | 3 | Recruiting | 1 |
| DB01233 | Metoclopramide | 3 | Recruiting | 1 |
| DB00788 | Naproxen | 3 | Withdrawn | 2 |
| DB00952 | Naratriptan | 3 | Withdrawn | 2 |
| DB06614 | Peramivir | 3 | Completed | 1 |
| DB06614 | Peramivir | 3 | Terminated | 1 |
| DB00860 | Prednisolone | 3 | Completed | 1 |
| DB00433 | Prochlorperazine | 3 | Terminated | 1 |
| DB00571 | Propranolol | 3 | Completed | 1 |
| DB00669 | Sumatriptan | 3 | Completed | 1 |
| DB00273 | Topiramate | 3 | Completed | 4 |
| DB00273 | Topiramate | 3 | Terminated | 1 |
| DB00316 | Acetaminophen | 4 | Completed | 1 |
| DB00945 | Acetylsalicylic acid | 4 | Completed | 1 |
| DB00321 | Amitriptyline | 4 | Terminated | 1 |
| DB00297 | Bupivacaine | 4 | Recruiting | 1 |
| DB01234 | Dexamethasone | 4 | Recruiting | 1 |
| DB01075 | Diphenhydramine | 4 | Completed | 1 |
| DB01628 | Etoricoxib | 4 | Completed | 1 |
| DB01628 | Etoricoxib | 4 | Unknown Status | 1 |
| DB00813 | Fentanyl | 4 | Not Yet Recruiting | 1 |
| DB00502 | Haloperidol | 4 | Active Not Recruiting | 1 |
| DB01050 | Ibuprofen | 4 | Completed | 1 |
| DB01221 | Ketamine | 4 | Completed | 1 |
| DB00465 | Ketorolac | 4 | Completed | 1 |
| DB01233 | Metoclopramide | 4 | Completed | 1 |
| DB00904 | Ondansetron | 4 | Completed | 1 |
| DB00230 | Pregabalin | 4 | Withdrawn | 1 |
| DB00433 | Prochlorperazine | 4 | Completed | 1 |
| DB00433 | Prochlorperazine | 4 | Recruiting | 1 |
| DB00571 | Propranolol | 4 | Terminated | 1 |
| DB00852 | Pseudoephedrine | 4 | Completed | 1 |
| DB09153 | Sodium Chloride | 4 | Active Not Recruiting | 1 |
| DB09153 | Sodium Chloride | 4 | Recruiting | 1 |
| DB08816 | Ticagrelor | 4 | Recruiting | 1 |
| DB00273 | Topiramate | 4 | Completed | 1 |
| DB00273 | Topiramate | 4 | Terminated | 1 |
| DB00620 | Triamcinolone | 4 | Recruiting | 1 |
| DB00316 | Acetaminophen | Not Available | Completed | 1 |
| DB00819 | Acetazolamide | Not Available | Completed | 1 |
| DB00802 | Alfentanil | Not Available | Recruiting | 1 |
| DB01238 | Aripiprazole | Not Available | Recruiting | 1 |
| DB00181 | Baclofen | Not Available | Enrolling by Invitation | 1 |
| DB00083 | Botulinum Toxin Type A | Not Available | Active Not Recruiting | 1 |
| DB00083 | Botulinum Toxin Type A | Not Available | Completed | 1 |
| DB00297 | Bupivacaine | Not Available | Enrolling by Invitation | 1 |
| DB06774 | Capsaicin | Not Available | Enrolling by Invitation | 1 |
| DB00411 | Carbachol | Not Available | Completed | 2 |
| DB00438 | Ceftazidime | Not Available | Recruiting | 1 |
| DB00369 | Cidofovir | Not Available | Recruiting | 1 |
| DB00537 | Ciprofloxacin | Not Available | Recruiting | 1 |
| DB00363 | Clozapine | Not Available | Recruiting | 1 |
| DB00318 | Codeine | Not Available | Completed | 1 |
| DB00924 | Cyclobenzaprine | Not Available | Enrolling by Invitation | 1 |
| DB01234 | Dexamethasone | Not Available | Recruiting | 1 |
| DB00829 | Diazepam | Not Available | Recruiting | 1 |
| DB00586 | Diclofenac | Not Available | Enrolling by Invitation | 1 |
| DB12789 | Dinoprost | Not Available | Completed | 1 |
| DB00917 | Dinoprostone | Not Available | Completed | 1 |
| DB01075 | Diphenhydramine | Not Available | Completed | 1 |
| DB00668 | Epinephrine | Not Available | Enrolling by Invitation | 1 |
| DB01240 | Epoprostenol | Not Available | Unknown Status | 1 |
| DB00712 | Flurbiprofen | Not Available | Enrolling by Invitation | 1 |
| DB01320 | Fosphenytoin | Not Available | Recruiting | 1 |
| DB00996 | Gabapentin | Not Available | Enrolling by Invitation | 1 |
| DB00502 | Haloperidol | Not Available | Recruiting | 1 |
| DB01109 | Heparin | Not Available | Recruiting | 1 |
| DB00327 | Hydromorphone | Not Available | Recruiting | 1 |
| DB01050 | Ibuprofen | Not Available | Completed | 1 |
| DB01221 | Ketamine | Not Available | Completed | 1 |
| DB01221 | Ketamine | Not Available | Enrolling by Invitation | 1 |
| DB01202 | Levetiracetam | Not Available | Recruiting | 1 |
| DB00281 | Lidocaine | Not Available | Enrolling by Invitation | 1 |
| DB08815 | Lurasidone | Not Available | Recruiting | 1 |
| DB09337 | Medical air | Not Available | Completed | 1 |
| DB00814 | Meloxicam | Not Available | Enrolling by Invitation | 1 |
| DB00825 | Menthol | Not Available | Completed | 1 |
| DB00825 | Menthol | Not Available | Enrolling by Invitation | 1 |
| DB00760 | Meropenem | Not Available | Recruiting | 1 |
| DB00959 | Methylprednisolone | Not Available | Recruiting | 1 |
| DB01233 | Metoclopramide | Not Available | Completed | 1 |
| DB00683 | Midazolam | Not Available | Recruiting | 1 |
| DB01618 | Molindone | Not Available | Recruiting | 1 |
| DB00295 | Morphine | Not Available | Recruiting | 1 |
| DB00622 | Nicardipine | Not Available | Recruiting | 1 |
| DB00334 | Olanzapine | Not Available | Recruiting | 2 |
| DB00198 | Oseltamivir | Not Available | Recruiting | 1 |
| DB09140 | Oxygen | Not Available | Completed | 1 |
| DB00652 | Pentazocine | Not Available | Completed | 1 |
| DB00312 | Pentobarbital | Not Available | Recruiting | 1 |
| DB00750 | Prilocaine | Not Available | Enrolling by Invitation | 1 |
| DB00818 | Propofol | Not Available | Recruiting | 1 |
| DB01224 | Quetiapine | Not Available | Recruiting | 1 |
| DB00734 | Risperidone | Not Available | Recruiting | 1 |
| DB00533 | Rofecoxib | Not Available | Completed | 1 |
| DB00296 | Ropivacaine | Not Available | Completed | 1 |
| DB00669 | Sumatriptan | Not Available | Enrolling by Invitation | 1 |
| DB00373 | Timolol | Not Available | Recruiting | 1 |
| DB00697 | Tizanidine | Not Available | Enrolling by Invitation | 1 |
| DB00684 | Tobramycin | Not Available | Recruiting | 1 |
| DB00273 | Topiramate | Not Available | Enrolling by Invitation | 1 |
| DB00273 | Topiramate | Not Available | Recruiting | 1 |
| DB00273 | Topiramate | Not Available | Withdrawn | 1 |
| DB00313 | Valproic Acid | Not Available | Recruiting | 1 |
| DB00682 | Warfarin | Not Available | Recruiting | 1 |
| DB01593 | Zinc | Not Available | Completed | 1 |
| DB00246 | Ziprasidone | Not Available | Recruiting | 1 |