Immune Thrombocytopenic Purpura ( ITP )

Also known as: Immune Thrombocytopenic Purpura (ITP) / Immune Thrombocytopenic Purpura / Werlhof's disease / ITP / Purpura, Thrombocytopenic, Idiopathic / Hemorrhagic (thrombocytopenic) purpura / Werlhof's syndrome / Idiopathic purpura / Idiopathic thrombocytopenic purpura

DrugDrug NameDrug Description
DB00570VinblastineAntitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
DB00541VincristineVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
DrugDrug NameTargetType
DB00570VinblastineTubulin beta chaintarget
DB00570VinblastineTranscription factor AP-1target
DB00570VinblastineCytochrome P450 3A4enzyme
DB00570VinblastineMultidrug resistance protein 1transporter
DB00570VinblastineMultidrug resistance-associated protein 1transporter
DB00570VinblastineCanalicular multispecific organic anion transporter 1transporter
DB00570VinblastineMultidrug resistance-associated protein 6transporter
DB00570VinblastineBile salt export pumptransporter
DB00570VinblastineTubulin alpha-1A chaintarget
DB00570VinblastineTubulin delta chaintarget
DB00570VinblastineTubulin epsilon chaintarget
DB00570VinblastineTubulin gamma-1 chaintarget
DB00570VinblastineCytochrome P450 2D6enzyme
DB00570VinblastineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineTubulin beta chaintarget
DB00541VincristineCytochrome P450 3A4enzyme
DB00541VincristineCytochrome P450 3A5enzyme
DB00541VincristineCytochrome P450 3A7enzyme
DB00541VincristineMultidrug resistance protein 1transporter
DB00541VincristineCanalicular multispecific organic anion transporter 2transporter
DB00541VincristineSolute carrier family 22 member 3transporter
DB00541VincristineMultidrug resistance-associated protein 1transporter
DB00541VincristineMultidrug resistance-associated protein 7transporter
DB00541VincristineCanalicular multispecific organic anion transporter 1transporter
DB00541VincristineBile salt export pumptransporter
DB00541VincristineATP-binding cassette sub-family G member 2transporter
DB00541VincristineTubulin alpha-4A chaintarget
DB00541VincristineRalA-binding protein 1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B1transporter
DB00541VincristineSolute carrier organic anion transporter family member 1B3transporter
DrugDrug NamePhaseStatusCount
DB00028Immune Globulin Human1 / 2Recruiting1
DB00073Rituximab1 / 2Completed1
DB01234Dexamethasone2Completed2
DB06210Eltrombopag2Completed1
DB06210Eltrombopag2Recruiting1
DB00073Rituximab2Completed1
DB05209Rozrolimupab2Completed1
DB12330Blisibimod2 / 3Withdrawn1
DB00531Cyclophosphamide2 / 3Completed1
DB00898Ethanol2 / 3Completed1
DB00635Prednisone2 / 3Completed1
DB00073Rituximab2 / 3Completed1
DB00541Vincristine2 / 3Completed1
DB06210Eltrombopag3Active Not Recruiting1
DB06210Eltrombopag3Recruiting1
DB12010Fostamatinib3Active Not Recruiting1
DB12010Fostamatinib3Completed2
DB00028Immune Globulin Human3Active Not Recruiting1
DB00028Immune Globulin Human3Completed4
DB00959Methylprednisolone3Completed1
DB00635Prednisone3Terminated1
DB06646Tamatinib3Active Not Recruiting1
DB00028Immune Globulin Human4Completed1
DB06210EltrombopagNot AvailableCompleted1
DB12010FostamatinibNot AvailableNo Longer Available1
DB00073RituximabNot AvailableCompleted1
DB05332RomiplostimNot AvailableCompleted1
DB00877SirolimusNot AvailableCompleted1
DB06646TamatinibNot AvailableNo Longer Available1
DB00755TretinoinNot AvailableCompleted1