Refractory Chronic Lymphocytic Leukemia

Also known as: Chronic lymphocytic leukemia refractory / Refractory CLL / Refractory Chronic lymphocytic leukemia / Chronic Lymphocytic Leukaemia Refractory

DrugDrug NameDrug Description
DB00480LenalidomideLenalidomide (initially known as CC-5013 and marketed as Revlimid® by Celgene) is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic modality, but has also shown efficacy in the hematological disorders known as the myelodysplastic syndromes. [Wikipedia] FDA approved on December 27, 2005.
DB06650OfatumumabOfatumumab is a human monoclonal antibody for the CD20 protein. Ofatumumab binds specifically to both the small and large extracellular loops of the CD20 molecule. The CD20 molecule is expressed on normal B lymphocytes (pre-B- to mature B-lymphocyte) and on B-cell CLL. The Fab domain of ofatumumab binds to the CD20 molecule and the Fc domain mediates immune effector functions to result in B-cell lysis in vitro. Ofatumumab received FDA approval on April 17, 2014, for use in combination with chlorambucil, for the treatment of previously untreated patients with CLL for whom fludarabine-based therapy is considered inappropriate. Ofatumumab was also approved by Health Canada on August 13th, 2012.
DB00526OxaliplatinOxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. It is typically administered in combination with fluorouracil and leucovorin in a combination known as Folfox for the treatment of colorectal cancer. Compared to cisplatin the two amine groups are replaced by cyclohexyldiamine for improved antitumour activity. The chlorine ligands are replaced by the oxalato bidentate derived from oxalic acid in order to improve water solubility. Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin®.
DrugDrug NamePhaseStatusCount
DB12707AR-421Active Not Recruiting1
DB00041Aldesleukin1Completed1
DB00087Alemtuzumab1Terminated1
DB05220Alisertib1Active Not Recruiting1
DB12442Alvespimycin1Terminated1
DB03496Alvocidib1Completed2
DB03496Alvocidib1Terminated1
DB06769Bendamustine1Active Not Recruiting1
DB06769Bendamustine1Recruiting1
DB06769Bendamustine1Terminated2
DB00188Bortezomib1Completed2
DB00188Bortezomib1Terminated1
DB11752Bryostatin 11Completed1
DB11666Buparlisib1Active Not Recruiting1
DB12109CPI-6131Terminated1
DB08889Carfilzomib1Completed1
DB00493Cefotaxime1Active Not Recruiting1
DB00493Cefotaxime1Completed2
DB00493Cefotaxime1Terminated1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Completed2
DB00531Cyclophosphamide1Not Yet Recruiting1
DB00531Cyclophosphamide1Terminated1
DB00091Cyclosporine1Completed1
DB01254Dasatinib1Completed1
DB01262Decitabine1Completed1
DB00380Dexrazoxane1Terminated1
DB00997Doxorubicin1Terminated1
DB00773Etoposide1Active Not Recruiting1
DB00773Etoposide1Terminated1
DB01590Everolimus1Recruiting1
DB01073Fludarabine1Active Not Recruiting1
DB01073Fludarabine1Completed4
DB01073Fludarabine1Not Yet Recruiting1
DB01073Fludarabine1Terminated1
DB09053Ibrutinib1Active Not Recruiting3
DB09053Ibrutinib1Recruiting1
DB09053Ibrutinib1Terminated1
DB00619Imatinib1Completed1
DB06186Ipilimumab1Completed1
DB00480Lenalidomide1Active Not Recruiting2
DB00480Lenalidomide1Completed2
DB00331Metformin1Recruiting1
DB00688Mycophenolate mofetil1Completed1
DB12191Obatoclax1Terminated2
DB06650Ofatumumab1Active Not Recruiting1
DB00526Oxaliplatin1Terminated1
DB00503Ritonavir1Recruiting1
DB00073Rituximab1Active Not Recruiting1
DB00073Rituximab1Completed3
DB00073Rituximab1Terminated4
DB06176Romidepsin1Completed1
DB06176Romidepsin1Recruiting1
DB11965SJG-1361Terminated1
DB11942Selinexor1Recruiting1
DB00398Sorafenib1Completed1
DB01268Sunitinib1Completed1
DB06398Tanespimycin1Terminated2
DB13881Tisagenlecleucel1Completed1
DB00313Valproic Acid1Completed1
DB00541Vincristine1Completed1
DB00541Vincristine1Terminated1
DB02546Vorinostat1Active Not Recruiting1
DB00087Alemtuzumab1 / 2Active Not Recruiting1
DB03496Alvocidib1 / 2Completed1
DB06769Bendamustine1 / 2Completed2
DB00262Carmustine1 / 2Active Not Recruiting2
DB00493Cefotaxime1 / 2Active Not Recruiting2
DB00531Cyclophosphamide1 / 2Active Not Recruiting2
DB00531Cyclophosphamide1 / 2Recruiting1
DB00091Cyclosporine1 / 2Active Not Recruiting4
DB00987Cytarabine1 / 2Active Not Recruiting2
DB12021Dinaciclib1 / 2Active Not Recruiting1
DB12121Entospletinib1 / 2Recruiting1
DB00773Etoposide1 / 2Active Not Recruiting2
DB01590Everolimus1 / 2Active Not Recruiting1
DB05076Fenretinide1 / 2Terminated1
DB01073Fludarabine1 / 2Active Not Recruiting5
DB01073Fludarabine1 / 2Recruiting1
DB09053Ibrutinib1 / 2Active Not Recruiting1
DB01042Melphalan1 / 2Active Not Recruiting2
DB00688Mycophenolate mofetil1 / 2Active Not Recruiting5
DB08935Obinutuzumab1 / 2Active Not Recruiting1
DB08935Obinutuzumab1 / 2Recruiting1
DB06650Ofatumumab1 / 2Active Not Recruiting1
DB06603Panobinostat1 / 2Active Not Recruiting1
DB00073Rituximab1 / 2Active Not Recruiting1
DB00073Rituximab1 / 2Completed2
DB00073Rituximab1 / 2Terminated1
DB00864Tacrolimus1 / 2Active Not Recruiting1
DB07232Veliparib1 / 2Completed1
DB11581Venetoclax1 / 2Active Not Recruiting1
DB00087Alemtuzumab2Active Not Recruiting2
DB03496Alvocidib2Completed1
DB03496Alvocidib2Terminated1
DB09312Antilymphocyte immunoglobulin (horse)2Active Not Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Active Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB01076Atorvastatin2Recruiting1
DB00394Beclomethasone dipropionate2Completed1
DB00112Bevacizumab2Completed1
DB00112Bevacizumab2Withdrawn1
DB00188Bortezomib2Active Not Recruiting1
DB01008Busulfan2Active Not Recruiting1
DB01008Busulfan2Completed1
DB00262Carmustine2Recruiting1
DB04849Cediranib2Completed1
DB00493Cefotaxime2Active Not Recruiting1
DB00493Cefotaxime2Completed2
DB00493Cefotaxime2Recruiting1
DB00493Cefotaxime2Suspended1
DB00493Cefotaxime2Withdrawn1
DB00531Cyclophosphamide2Active Not Recruiting2
DB00531Cyclophosphamide2Completed2
DB00531Cyclophosphamide2Recruiting1
DB00531Cyclophosphamide2Suspended1
DB00531Cyclophosphamide2Withdrawn1
DB00091Cyclosporine2Active Not Recruiting3
DB00091Cyclosporine2Completed3
DB00091Cyclosporine2Recruiting2
DB00091Cyclosporine2Suspended1
DB00987Cytarabine2Recruiting1
DB01254Dasatinib2Active Not Recruiting1
DB01609Deferasirox2Terminated1
DB01234Dexamethasone2Active Not Recruiting1
DB00514Dextromethorphan2Active Not Recruiting1
DB00773Etoposide2Recruiting1
DB01073Fludarabine2Active Not Recruiting7
DB01073Fludarabine2Completed2
DB01073Fludarabine2Recruiting3
DB01073Fludarabine2Suspended1
DB01073Fludarabine2Terminated1
DB01073Fludarabine2Withdrawn2
DB09053Ibrutinib2Recruiting3
DB09054Idelalisib2Recruiting1
DB00480Lenalidomide2Suspended1
DB00480Lenalidomide2Terminated1
DB01042Melphalan2Active Not Recruiting1
DB01042Melphalan2Recruiting1
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Completed2
DB00959Methylprednisolone2Completed1
DB00688Mycophenolate mofetil2Active Not Recruiting7
DB00688Mycophenolate mofetil2Completed3
DB00688Mycophenolate mofetil2Recruiting3
DB00688Mycophenolate mofetil2Suspended1
DB00688Mycophenolate mofetil2Withdrawn1
DB00904Ondansetron2Completed1
DB09037Pembrolizumab2Recruiting1
DB00073Rituximab2Active Not Recruiting4
DB00073Rituximab2Terminated1
DB00073Rituximab2Withdrawn1
DB00877Sirolimus2Active Not Recruiting1
DB00877Sirolimus2Recruiting1
DB00398Sorafenib2Terminated1
DB12369Sotrastaurin2Withdrawn1
DB01268Sunitinib2Completed1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Active Not Recruiting4
DB00864Tacrolimus2Completed3
DB00864Tacrolimus2Recruiting1
DB00864Tacrolimus2Withdrawn1
DB06287Temsirolimus2Completed1
DB06287Temsirolimus2Terminated1
DB01041Thalidomide2Completed1
DB01041Thalidomide2Terminated1
DB11581Venetoclax2Recruiting1
DB02546Vorinostat2Completed1
DB00091Cyclosporine3Active Not Recruiting1
DB00091Cyclosporine3Completed1
DB01073Fludarabine3Active Not Recruiting1
DB01073Fludarabine3Completed1
DB00688Mycophenolate mofetil3Active Not Recruiting1
DB00688Mycophenolate mofetil3Completed1
DB00877Sirolimus3Completed1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableActive Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableActive Not Recruiting1
DB01169Arsenic trioxideNot AvailableTerminated1
DB01008BusulfanNot AvailableActive Not Recruiting1
DB00958CarboplatinNot AvailableActive Not Recruiting1
DB00262CarmustineNot AvailableActive Not Recruiting1
DB00493CefotaximeNot AvailableActive Not Recruiting1
DB00493CefotaximeNot AvailableRecruiting1
DB00531CyclophosphamideNot AvailableActive Not Recruiting1
DB00531CyclophosphamideNot AvailableRecruiting1
DB00091CyclosporineNot AvailableActive Not Recruiting3
DB00091CyclosporineNot AvailableRecruiting1
DB00773EtoposideNot AvailableActive Not Recruiting1
DB00773EtoposideNot AvailableTerminated1
DB00099FilgrastimNot AvailableTerminated2
DB01073FludarabineNot AvailableActive Not Recruiting3
DB01073FludarabineNot AvailableRecruiting1
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB01356LithiumNot AvailableCompleted1
DB01042MelphalanNot AvailableActive Not Recruiting2
DB00688Mycophenolate mofetilNot AvailableActive Not Recruiting3
DB00688Mycophenolate mofetilNot AvailableRecruiting1
DB00039PaliferminNot AvailableCompleted1
DB06809PlerixaforNot AvailableTerminated2
DB04572ThiotepaNot AvailableActive Not Recruiting1
DB01610ValganciclovirNot AvailableCompleted1