Liver Cirrhosis

Also known as: Cirrhosis, Liver / Cirrhosis / Cirrhosis (of liver) NOS / Cirrhosis of liver / Cirrhosis liver / Hepatic cirrhosis NOS / Hepatic cirrhosis

DrugDrug NameDrug Description
DB00903Etacrynic acidA compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
DB00421SpironolactoneA potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
DB01015SulfamethoxazoleA bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
DB00384TriamtereneA pteridine that is used as a mild diuretic.
DrugDrug NameTargetType
DB00903Etacrynic acidSolute carrier family 12 member 1target
DB00903Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1target
DB00903Etacrynic acidGlutathione S-transferase A2enzyme
DB00903Etacrynic acidSerum albumincarrier
DB00903Etacrynic acidSolute carrier family 22 member 6transporter
DB00903Etacrynic acidLymphoid enhancer-binding factor 1target
DB00903Etacrynic acidGlutathione S-transferase Ptarget
DB00421SpironolactoneMineralocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 2C8enzyme
DB00421SpironolactoneCanalicular multispecific organic anion transporter 1transporter
DB00421SpironolactoneMultidrug resistance protein 1transporter
DB00421SpironolactoneSolute carrier organic anion transporter family member 1A2transporter
DB00421SpironolactoneCytochrome P450 11B1, mitochondrialenzyme
DB00421SpironolactoneAndrogen receptortarget
DB00421SpironolactoneProgesterone receptortarget
DB00421SpironolactoneGlucocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 11B2, mitochondrialtarget
DB00421Spironolactone17alpha-hydroxylasetarget
DB00421Spironolactone17,20-desmolasetarget
DB00421Spironolactone3-oxo-5-alpha-steroid 4-dehydrogenasetarget
DB00421SpironolactoneSex hormone-binding globulintarget
DB00421SpironolactoneVoltage-dependent calcium channeltarget
DB00421SpironolactoneDihydrotestosterone receptortarget
DB00421SpironolactoneNuclear receptor subfamily 1 group I member 2target
DB00421SpironolactoneBile salt export pumptransporter
DB01015SulfamethoxazoleBifunctional protein FolCtarget
DB01015SulfamethoxazoleCytochrome P450 2C9enzyme
DB01015SulfamethoxazoleSerum albumincarrier
DB01015SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
DB01015SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
DB01015SulfamethoxazoleProstaglandin G/H synthase 1enzyme
DB01015SulfamethoxazoleUDP-glucuronosyltransferase 1-9enzyme
DB01015SulfamethoxazoleDihydropteroate synthasetarget
DB01015SulfamethoxazoleCytochrome P450 2C8enzyme
DB01015SulfamethoxazoleCytochrome P450 3A4enzyme
DB01015SulfamethoxazoleGlutathione S-transferase Ptarget
DB01015SulfamethoxazoleBile salt export pumptransporter
DB00384TriamtereneAmiloride-sensitive sodium channel subunit gammatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit alphatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit betatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit deltatarget
DB00384TriamtereneCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB01611Hydroxychloroquine0Completed1
DB00203Sildenafil0Recruiting1
DB01394Colchicine1Unknown Status1
DB06210Eltrombopag1Completed1
DB00153Ergocalciferol1Withdrawn1
DB00099Filgrastim1Completed1
DB12340Navitoclax1Recruiting1
DB00203Sildenafil1Terminated1
DB09143Sonidegib1Active Not Recruiting1
DB00398Sorafenib1Recruiting1
DB11815Tilarginine1Completed1
DB11815Tilarginine1Unknown Status1
DB06026Tivantinib1Completed1
DB11094Vitamin D1Withdrawn1
DB11121Chloroxylenol1 / 2Completed1
DB00530Erlotinib1 / 2Recruiting1
DB01205Flumazenil1 / 2Withdrawn1
DB00709Lamivudine1 / 2Unknown Status1
DB05914Mesenchymal Stem Cells1 / 2Recruiting1
DB05914Mesenchymal Stem Cells1 / 2Unknown Status2
DB00104Octreotide1 / 2Completed1
DB09153Sodium Chloride1 / 2Completed1
DB09153Sodium Chloride1 / 2Withdrawn1
DB01586Ursodeoxycholic acid1 / 2Unknown Status1
DB00181Baclofen2Completed1
DB00559Bosentan2Terminated1
DB00564Carbamazepine2Recruiting1
DB11758Cenicriviroc2Enrolling by Invitation1
DB05868Ciluprevir2Completed1
DB13130Ciluprevir2Completed1
DB00872Conivaptan2Completed1
DB05408Emricasan2Active Not Recruiting1
DB05408Emricasan2Completed3
DB05408Emricasan2Terminated1
DB00700Eplerenone2Withdrawn1
DB01590Everolimus2Unknown Status1
DB00695Furosemide2Completed1
DB06170Glycerol phenylbutyrate2Completed1
DB12321Ifetroban2Completed1
DB00033Interferon gamma-1b2Completed1
DB00581Lactulose2Completed1
DB00211Midodrine2Completed1
DB12539Oltipraz2Completed1
DB00811Ribavirin2Completed1
DB01220Rifaximin2Completed1
DB01220Rifaximin2Unknown Status1
DB05794Serelaxin2Completed1
DB00641Simvastatin2Completed1
DB00641Simvastatin2Recruiting1
DB08934Sofosbuvir2Completed1
DB02638Terlipressin2Recruiting1
DB00373Timolol2Completed1
DB06212Tolvaptan2Completed1
DB01136Carvedilol2 / 3Recruiting1
DB00438Ceftazidime2 / 3Terminated1
DB11121Chloroxylenol2 / 3Recruiting1
DB00080Daptomycin2 / 3Terminated1
DB09255Dextran2 / 3Completed1
DB00760Meropenem2 / 3Terminated1
DB00211Midodrine2 / 3Active Not Recruiting1
DB01059Norfloxacin2 / 3Unknown Status1
DB00019Pegfilgrastim2 / 3Completed1
DB00008Peginterferon alfa-2a2 / 3Completed1
DB00082Pegvisomant2 / 3Completed1
DB00571Propranolol2 / 3Recruiting2
DB00811Ribavirin2 / 3Completed1
DB01220Rifaximin2 / 3Recruiting1
DB01098Rosuvastatin2 / 3Recruiting1
DB00360Sapropterin2 / 3Completed1
DB00052Somatotropin2 / 3Recruiting1
DB02638Terlipressin2 / 3Completed2
DB06212Tolvaptan2 / 3Active Not Recruiting1
DB01373Calcium3Not Yet Recruiting2
DB01373Calcium3Recruiting2
DB06724Calcium Carbonate3Not Yet Recruiting2
DB06724Calcium Carbonate3Recruiting1
DB01136Carvedilol3Completed1
DB00515Cisplatin3Terminated1
DB00924Cyclobenzaprine3Not Yet Recruiting1
DB09102Daclatasvir3Completed1
DB09183Dasabuvir3Completed1
DB01234Dexamethasone3Terminated1
DB00841Dobutamine3Completed1
DB00965Ethiodized oil3Terminated1
DB00099Filgrastim3Completed1
DB00996Gabapentin3Completed1
DB00996Gabapentin3Not Yet Recruiting1
DB00441Gemcitabine3Terminated1
DB00062Human Serum Albumin3Completed1
DB00062Human Serum Albumin3Terminated1
DB00741Hydrocortisone3Recruiting1
DB00028Immune Globulin Human3Completed1
DB00105Interferon alfa-2b3Completed1
DB00709Lamivudine3Completed2
DB09027Ledipasvir3Completed1
DB00331Metformin3Terminated1
DB00423Methocarbamol3Recruiting1
DB00264Metoprolol3Completed1
DB00683Midazolam3Recruiting1
DB06230Nalmefene3Not Yet Recruiting1
DB01059Norfloxacin3Recruiting1
DB01059Norfloxacin3Terminated1
DB09296Ombitasvir3Completed1
DB01173Orphenadrine3Recruiting1
DB00526Oxaliplatin3Terminated1
DB09297Paritaprevir3Completed1
DB00008Peginterferon alfa-2a3Completed2
DB00022Peginterferon alfa-2b3Completed3
DB00022Peginterferon alfa-2b3Terminated1
DB00806Pentoxifylline3Completed1
DB00230Pregabalin3Completed1
DB00818Propofol3Recruiting1
DB00571Propranolol3Completed1
DB00571Propranolol3Recruiting1
DB00571Propranolol3Terminated1
DB00811Ribavirin3Completed8
DB00811Ribavirin3Terminated1
DB01220Rifaximin3Completed1
DB01220Rifaximin3Recruiting3
DB00503Ritonavir3Completed1
DB06228Rivaroxaban3Recruiting1
DB00641Simvastatin3Completed2
DB00641Simvastatin3Not Yet Recruiting1
DB09153Sodium Chloride3Recruiting1
DB08934Sofosbuvir3Completed2
DB00864Tacrolimus3Completed1
DB01265Telbivudine3Completed2
DB02638Terlipressin3Completed1
DB01284Tetracosactide3Recruiting1
DB00373Timolol3Completed1
DB06212Tolvaptan3Completed5
DB00682Warfarin3Recruiting1
DB00945Acetylsalicylic acid4Completed1
DB00945Acetylsalicylic acid4Recruiting1
DB00718Adefovir Dipivoxil4Completed1
DB06403Ambrisentan4Withdrawn1
DB01060Amoxicillin4Unknown Status1
DB00207Azithromycin4Unknown Status1
DB00074Basiliximab4Completed1
DB01136Carvedilol4Enrolling by Invitation1
DB01136Carvedilol4Recruiting4
DB00493Cefotaxime4Completed1
DB00493Cefotaxime4Unknown Status1
DB01212Ceftriaxone4Completed1
DB11121Chloroxylenol4Completed1
DB11121Chloroxylenol4Recruiting1
DB00537Ciprofloxacin4Completed1
DB00537Ciprofloxacin4Withdrawn1
DB00766Clavulanic acid4Unknown Status1
DB09102Daclatasvir4Active Not Recruiting1
DB00975Dipyridamole4Completed1
DB00975Dipyridamole4Recruiting1
DB00442Entecavir4Completed2
DB00442Entecavir4Recruiting1
DB00813Fentanyl4Unknown Status1
DB00695Furosemide4Completed2
DB08884Gadoxetic acid4Active Not Recruiting1
DB00062Human Serum Albumin4Recruiting1
DB01598Imipenem4Unknown Status1
DB01309Insulin Glulisine4Unknown Status1
DB00030Insulin Human4Unknown Status1
DB00047Insulin glargine4Unknown Status1
DB01020Isosorbide Mononitrate4Completed1
DB00581Lactulose4Completed1
DB00581Lactulose4Terminated1
DB00581Lactulose4Unknown Status1
DB09027Ledipasvir4Active Not Recruiting1
DB00454Meperidine4Completed1
DB00331Metformin4Recruiting1
DB09241Methylene blue4Completed1
DB00959Methylprednisolone4Completed1
DB00683Midazolam4Completed1
DB00683Midazolam4Unknown Status1
DB00211Midodrine4Completed1
DB01024Mycophenolic acid4Completed1
DB01203Nadolol4Completed2
DB08813Nadroparin4Completed1
DB08813Nadroparin4Not Yet Recruiting1
DB08813Nadroparin4Recruiting2
DB01059Norfloxacin4Completed1
DB00104Octreotide4Completed1
DB01132Pioglitazone4Completed1
DB00457Prazosin4Completed1
DB00635Prednisone4Completed1
DB00818Propofol4Unknown Status1
DB00571Propranolol4Completed1
DB00571Propranolol4Recruiting2
DB00571Propranolol4Unknown Status3
DB00980Ramelteon4Completed1
DB00811Ribavirin4Active Not Recruiting1
DB01220Rifaximin4Completed2
DB01220Rifaximin4Recruiting1
DB01220Rifaximin4Terminated1
DB01220Rifaximin4Unknown Status2
DB00268Ropinirole4Enrolling by Invitation1
DB00641Simvastatin4Unknown Status2
DB09153Sodium Chloride4Completed1
DB08934Sofosbuvir4Active Not Recruiting2
DB00421Spironolactone4Completed1
DB00421Spironolactone4Recruiting1
DB00421Spironolactone4Unknown Status1
DB00864Tacrolimus4Completed1
DB00820Tadalafil4Withdrawn1
DB01265Telbivudine4Unknown Status1
DB02638Terlipressin4Active Not Recruiting1
DB02638Terlipressin4Completed1
DB02638Terlipressin4Suspended1
DB04900Thymalfasin4Completed2
DB06212Tolvaptan4Completed1
DB00302Tranexamic acid4Recruiting1
DB00512Vancomycin4Unknown Status1
DB00862Vardenafil4Recruiting1
DB00163Vitamin E4Enrolling by Invitation1
DB00682Warfarin4Completed1
DB00682Warfarin4Not Yet Recruiting1
DB00682Warfarin4Recruiting2
DB00718Adefovir DipivoxilNot AvailableCompleted1
DB00626BacitracinNot AvailableRecruiting1
DB00181BaclofenNot AvailableUnknown Status1
DB08873BoceprevirNot AvailableCompleted1
DB01136CarvedilolNot AvailableCompleted1
DB01136CarvedilolNot AvailableNot Yet Recruiting1
DB01136CarvedilolNot AvailableRecruiting4
DB00229CefotiamNot AvailableActive Not Recruiting1
DB00229CefotiamNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableActive Not Recruiting1
DB09102DaclatasvirNot AvailableCompleted1
DB09183DasabuvirNot AvailableCompleted1
DB00035DesmopressinNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableUnknown Status1
DB00442EntecavirNot AvailableActive Not Recruiting1
DB00442EntecavirNot AvailableRecruiting1
DB00199ErythromycinNot AvailableCompleted1
DB00199ErythromycinNot AvailableUnknown Status1
DB09150Fludeoxyglucose F-18Not AvailableNot Yet Recruiting1
DB05276Hepatitis B Immune GlobulinNot AvailableCompleted1
DB00062Human Serum AlbuminNot AvailableActive Not Recruiting1
DB00062Human Serum AlbuminNot AvailableSuspended1
DB00062Human Serum AlbuminNot AvailableTerminated1
DB00581LactuloseNot AvailableCompleted3
DB00581LactuloseNot AvailableWithdrawn2
DB00709LamivudineNot AvailableActive Not Recruiting1
DB00709LamivudineNot AvailableCompleted1
DB09027LedipasvirNot AvailableCompleted1
DB00583LevocarnitineNot AvailableCompleted1
DB13139LevosalbutamolNot AvailableNot Yet Recruiting1
DB00760MeropenemNot AvailableRecruiting1
DB00683MidazolamNot AvailableCompleted1
DB00211MidodrineNot AvailableCompleted1
DB00211MidodrineNot AvailableWithdrawn1
DB08813NadroparinNot AvailableWithdrawn1
DB00994NeomycinNot AvailableRecruiting1
DB00994NeomycinNot AvailableUnknown Status1
DB00104OctreotideNot AvailableUnknown Status1
DB09296OmbitasvirNot AvailableCompleted1
DB00338OmeprazoleNot AvailableCompleted1
DB09297ParitaprevirNot AvailableCompleted1
DB09287Polyethylene glycolNot AvailableCompleted1
DB09287Polyethylene glycolNot AvailableWithdrawn1
DB00781Polymyxin B sulfateNot AvailableRecruiting1
DB00761Potassium chlorideNot AvailableCompleted1
DB00761Potassium chlorideNot AvailableWithdrawn1
DB09345PramocaineNot AvailableRecruiting1
DB00818PropofolNot AvailableCompleted1
DB00818PropofolNot AvailableUnknown Status1
DB00571PropranololNot AvailableCompleted3
DB00571PropranololNot AvailableRecruiting1
DB00811RibavirinNot AvailableCompleted1
DB01220RifaximinNot AvailableActive Not Recruiting1
DB01220RifaximinNot AvailableCompleted2
DB01220RifaximinNot AvailableNot Yet Recruiting1
DB01220RifaximinNot AvailableRecruiting2
DB00503RitonavirNot AvailableCompleted1
DB00020SargramostimNot AvailableRecruiting1
DB06290SimeprevirNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableWithdrawn1
DB01390Sodium bicarbonateNot AvailableCompleted1
DB01390Sodium bicarbonateNot AvailableWithdrawn1
DB09472Sodium sulfateNot AvailableCompleted1
DB09472Sodium sulfateNot AvailableWithdrawn1
DB08934SofosbuvirNot AvailableCompleted1
DB09099SomatostatinNot AvailableCompleted1
DB09099SomatostatinNot AvailableRecruiting1
DB09099SomatostatinNot AvailableUnknown Status1
DB00820TadalafilNot AvailableRecruiting1
DB05521TelaprevirNot AvailableCompleted1
DB02638TerlipressinNot AvailableCompleted1
DB02638TerlipressinNot AvailableNot Yet Recruiting1
DB02638TerlipressinNot AvailableUnknown Status1
DB00682WarfarinNot AvailableRecruiting1
DB00682WarfarinNot AvailableWithdrawn1
DB00425ZolpidemNot AvailableCompleted1