Interstitial Cystitis

Also known as: Cystitis, Interstitial / Interstitial Cystitides / Cystitis interstitial / Cystitis ulcerative

DrugDrug NameDrug Description
DB00091CiclosporinCyclosporine is a lipophilic cyclic polypeptide formed by 11 amino acids that presents powerful immunosuppressive and immunomodulatory properties.[A174088] It is isolated from the fungus _Beauveria nivea_ and it was first formulated as an injectable ethanolic solution in 1980 followed by a vegetable oil formulation in 1990.[A174049] This drug was first discovered in 1970 by Sandoz.[A174076] On the FDA records, the first approved product was registered by the company West-Ward Pharmaceuticals International in 1999.[L5149]
DB01093Dimethyl sulfoxideA highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
DB01109HeparinUnfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate.
DrugDrug NameTargetType
DB00091CiclosporinCalcium signal-modulating cyclophilin ligandtarget
DB00091CiclosporinPeptidyl-prolyl cis-trans isomerase Atarget
DB00091CiclosporinCalcineurin subunit B type 2target
DB00091CiclosporinCytochrome P450 3A5enzyme
DB00091CiclosporinCytochrome P450 3A4enzyme
DB00091CiclosporinCytochrome P450 3A7enzyme
DB00091CiclosporinMultidrug resistance protein 1transporter
DB00091CiclosporinCanalicular multispecific organic anion transporter 2transporter
DB00091CiclosporinBile salt export pumptransporter
DB00091CiclosporinSolute carrier organic anion transporter family member 1A2transporter
DB00091CiclosporinIleal sodium/bile acid cotransportertransporter
DB00091CiclosporinSodium/bile acid cotransportertransporter
DB00091CiclosporinSolute carrier family 22 member 6transporter
DB00091CiclosporinMultidrug resistance-associated protein 7transporter
DB00091CiclosporinCanalicular multispecific organic anion transporter 1transporter
DB00091CiclosporinATP-binding cassette sub-family G member 2transporter
DB00091CiclosporinSolute carrier organic anion transporter family member 1B1transporter
DB00091CiclosporinCytochrome P450 2C19enzyme
DB00091CiclosporinCytochrome P450 2C8enzyme
DB00091CiclosporinCytochrome P450 2C9enzyme
DB00091CiclosporinCytochrome P450 2D6enzyme
DB00091CiclosporinPeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CiclosporinSolute carrier organic anion transporter family member 1B3transporter
DB01093Dimethyl sulfoxideTransthyretincarrier
DB01093Dimethyl sulfoxideCytochrome P450 2C19enzyme
DB01093Dimethyl sulfoxideCytochrome P450 2D6enzyme
DB01093Dimethyl sulfoxideCytochrome P450 3A4enzyme
DB01109HeparinAntithrombin-IIItarget
DB01109HeparinCoagulation factor Xtarget
DB01109HeparinP-selectintarget
DB01109HeparinHeparanaseenzyme
DB01109HeparinFibroblast growth factor receptor 4target
DB01109HeparinFibroblast growth factor 4target
DB01109HeparinFibroblast growth factor 19target
DB01109HeparinFibroblast growth factor receptor 1target
DB01109HeparinFibroblast growth factor 1target
DB01109HeparinFibroblast growth factor receptor 2target
DB01109HeparinFibroblast growth factor 2target
DB01109HeparinPlatelet factor 4target
DB01109HeparinHepatocyte growth factortarget
DB01109HeparinThyroxine-binding globulincarrier
DrugDrug NamePhaseStatusCount
DB016325-O-phosphono-alpha-D-ribofuranosyl diphosphate1Not Yet Recruiting1
DB06774Capsaicin1 / 2Completed1
DB13012AQX-11252Completed1
DB00174Asparagine2Completed1
DB00083Botulinum toxin type A2Completed1
DB00091Ciclosporin2Completed1
DB11074Dimethicone2Not Yet Recruiting1
DB01093Dimethyl sulfoxide2Terminated1
DB00668Epinephrine2Recruiting1
DB12102Fulranumab2Terminated1
DB01109Heparin2Recruiting1
DB00281Lidocaine2Recruiting2
DB00540Nortriptyline2Not Yet Recruiting1
DB11058Petrolatum2Not Yet Recruiting1
DB12143Rezatomidine2Terminated1
DB00133Serine2Completed1
DB09153Sodium chloride2Completed1
DB12335Tanezumab2Terminated1
DB00620Triamcinolone2Recruiting1
DB13012AQX-11253Active Not Recruiting1
DB00051Adalimumab3Completed1
DB00321Amitriptyline3Completed1
DB08904Certolizumab pegol3Completed1
DB08893Mirabegron3Recruiting1
DB00688Mycophenolate mofetil3Terminated1
DB00043Omalizumab3Completed1
DB00083Botulinum toxin type A4Completed2
DB00633Dexmedetomidine4Completed1
DB00977Ethinylestradiol4Recruiting1
DB00996Gabapentin4Terminated1
DB00465Ketorolac4Completed1
DB00717Norethisterone4Recruiting1
DB00686Pentosan Polysulfate4Terminated1
DB09153Sodium chloride4Completed1
DB09301Chondroitin sulfateNot AvailableRecruiting1
DB01093Dimethyl sulfoxideNot AvailableUnknown Status2
DB00668EpinephrineNot AvailableTerminated1
DB00668EpinephrineNot AvailableWithdrawn1
DB06716FospropofolNot AvailableWithdrawn1
DB08818Hyaluronic acidNot AvailableRecruiting1
DB00281LidocaineNot AvailableTerminated1
DB00281LidocaineNot AvailableWithdrawn1
DB00107OxytocinNot AvailableCompleted1
DB12278PropiverineNot AvailableCompleted1