Refractory Hodgkin Lymphoma

Also known as: Refractory Hodgkin lymphoma / Hodgkin's disease refractory / Refractory Hodgkin's lymphoma / Refractory Hodgkin's disease / Hodgkin's disease NOS refractory

DrugDrug NameDrug Description
DB06769BendamustineAn antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
DB08870Brentuximab vedotinA CD30-directed antibody-drug conjugate used to treat various types of lymphoma.
DB00958CarboplatinA alkylating agent used to treat advanced ovarian cancer.
DB00262CarmustineAn alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others.
DB00515CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
DB01206LomustineAn alkylating agent used as a part of chemotherapeutic regimens for the treatment of primary and metastatic brain tumors as well as refractory or relapsed Hodgkin's disease in addition to surgical and/or radiotherapeutic treatments.
DB09035NivolumabA PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
DrugDrug NameTargetType
DB06769BendamustineCytochrome P450 1A2enzyme
DB08870Brentuximab vedotinTumor necrosis factor receptor superfamily member 8target
DB08870Brentuximab vedotinCytochrome P450 3A4enzyme
DB08870Brentuximab vedotinATP-binding cassette sub-family B member 5transporter
DB00958CarboplatinDNAtarget
DB00958CarboplatinHigh affinity copper uptake protein 1transporter
DB00958CarboplatinProbable low affinity copper uptake protein 2transporter
DB00958CarboplatinXanthine dehydrogenase/oxidaseenzyme
DB00958CarboplatinMyeloperoxidaseenzyme
DB00958CarboplatinGlutathione S-transferase theta-1enzyme
DB00958CarboplatinMetallothionein-1Aenzyme
DB00958CarboplatinMetallothionein-2enzyme
DB00958CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00958CarboplatinGlutathione S-transferase Penzyme
DB00958CarboplatinGlutathione S-transferase Mu 1enzyme
DB00958CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00958CarboplatinCopper-transporting ATPase 1transporter
DB00958CarboplatinCopper-transporting ATPase 2transporter
DB00958CarboplatinATP-binding cassette sub-family G member 2transporter
DB00958CarboplatinCanalicular multispecific organic anion transporter 1transporter
DB00262CarmustineGlutathione reductase, mitochondrialtarget
DB00262CarmustineDNAtarget
DB00262CarmustineRNAtarget
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinP-glycoprotein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB01206LomustineDNAtarget
DB01206LomustineCytochrome P450 3A4enzyme
DB01206LomustineCytochrome P450 2D6enzyme
DB01206LomustineStathmin-4target
DB09035NivolumabProgrammed cell death protein 1target
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide0Recruiting1
DB00091Cyclosporine0Recruiting1
DB01073Fludarabine0Recruiting1
DB00688Mycophenolate mofetil0Recruiting1
DB09035Nivolumab0Recruiting1
DB09037Pembrolizumab0Recruiting1
DB05220Alisertib1Completed1
DB05015Belinostat1Suspended1
DB08870Brentuximab vedotin1Active Not Recruiting1
DB08870Brentuximab vedotin1Recruiting1
DB01008Busulfan1Recruiting1
DB08889Carfilzomib1Suspended1
DB00531Cyclophosphamide1Recruiting1
DB00091Cyclosporine1Recruiting1
DB09331Daratumumab1Suspended1
DB01590Everolimus1Active Not Recruiting1
DB01073Fludarabine1Recruiting1
DB09502Fludeoxyglucose (18F)1Suspended1
DB13134Fluorine F-181Suspended1
DB00441Gemcitabine1Recruiting1
DB00441Gemcitabine1Suspended1
DB00160L-Alanine1Recruiting2
DB00480Lenalidomide1Recruiting1
DB00888Mechlorethamine1Recruiting2
DB01042Melphalan1Recruiting2
DB00688Mycophenolate mofetil1Recruiting1
DB09035Nivolumab1Suspended1
DB08935Obinutuzumab1Suspended1
DB09074Olaparib1Recruiting1
DB09037Pembrolizumab1Recruiting1
DB09037Pembrolizumab1Suspended1
DB00738Pentamidine1Recruiting1
DB00073Rituximab1Recruiting2
DB00073Rituximab1Suspended1
DB06176Romidepsin1Completed1
DB06176Romidepsin1Suspended1
DB00877Sirolimus1Active Not Recruiting1
DB00864Tacrolimus1Recruiting1
DB00072Trastuzumab1Suspended1
DB00661Verapamil1Recruiting1
DB02546Vorinostat1Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)1 / 2Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)1 / 2Recruiting1
DB06769Bendamustine1 / 2Recruiting1
DB02379Beta-D-Glucose1 / 2Active Not Recruiting2
DB02379Beta-D-Glucose1 / 2Recruiting1
DB08870Brentuximab vedotin1 / 2Recruiting2
DB01008Busulfan1 / 2Recruiting1
DB00958Carboplatin1 / 2Recruiting1
DB00262Carmustine1 / 2Active Not Recruiting2
DB00631Clofarabine1 / 2Recruiting1
DB06189Clofarabine1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Active Not Recruiting2
DB00531Cyclophosphamide1 / 2Recruiting1
DB00091Cyclosporine1 / 2Active Not Recruiting1
DB00987Cytarabine1 / 2Active Not Recruiting2
DB00773Etoposide1 / 2Active Not Recruiting2
DB00773Etoposide1 / 2Recruiting1
DB01073Fludarabine1 / 2Active Not Recruiting2
DB00441Gemcitabine1 / 2Recruiting2
DB01181Ifosfamide1 / 2Recruiting1
DB06186Ipilimumab1 / 2Recruiting2
DB00160L-Alanine1 / 2Active Not Recruiting2
DB00888Mechlorethamine1 / 2Active Not Recruiting2
DB01042Melphalan1 / 2Active Not Recruiting2
DB12498Mogamulizumab1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Active Not Recruiting2
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting3
DB09037Pembrolizumab1 / 2Recruiting1
DB00073Rituximab1 / 2Recruiting1
DB00864Tacrolimus1 / 2Active Not Recruiting1
DB00864Tacrolimus1 / 2Recruiting1
DB02379Beta-D-Glucose2Recruiting1
DB08870Brentuximab vedotin2Completed1
DB08870Brentuximab vedotin2Recruiting3
DB00958Carboplatin2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Recruiting1
DB00091Cyclosporine2Active Not Recruiting1
DB00773Etoposide2Recruiting1
DB15223Flotetuzumab2Not Yet Recruiting1
DB01073Fludarabine2Active Not Recruiting1
DB09053Ibrutinib2Active Not Recruiting1
DB09053Ibrutinib2Recruiting2
DB01181Ifosfamide2Recruiting1
DB12154Itacitinib2Terminated1
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB06132Nivolumab2Recruiting2
DB09035Nivolumab2Recruiting3
DB05471SGN-302Recruiting1
DB12887Tazemetostat2Recruiting1
DB00091Cyclosporine3Active Not Recruiting1
DB00091Cyclosporine3Completed1
DB01073Fludarabine3Active Not Recruiting1
DB01073Fludarabine3Completed1
DB00688Mycophenolate mofetil3Active Not Recruiting1
DB00688Mycophenolate mofetil3Completed1
DB00877Sirolimus3Completed1