Type 2 Diabetes Mellitus Completed Phase 2 Trials for Metformin (DB00331)

Also known as: Diabetes Mellitus Non-insulin-dependent / Type-2 Diabetes Mellitus / Diabetes Mellitus Type 2 (T2DM) / Diabetes Mellitus Type-2 / Type 2 Diabetes (T2DM) / Diabetes, Type 2 / Diabetes Mellitus, Type 2 (T2DM) / Diabetes Mellitus´╝îType 2 / Diabetes Type II / Type-II Diabetes Mellitus / Diabetes Mellitus 2 Type / T2DM / Diabetes Mellitus Type II / Type II Diabetes / Diabetes Mellitus, Type 2 / Type 2 Diabetes Mellitus (T2DM) / Diabetes Type Two / Diabetes Mellitus - Type 2 / Diabetes, Type II / Non-Insulin-Dependent Diabetes Mellitus / Diabetes Mellitus. Type 2 / Diabetes Type 2 / Type 2 Diabetes Mellitus (T2D) / Type 2 Diabetes (T2D) / Type II; Diabetes / Type II Diabetes Mellitus / Diabetes Mellitus, Type II / NIDDM / Type-2 Diabetes / Type 2 Diabetes Mellitus(T2DM) / Type 2 Diabetes / Type 2-diabetes / Noninsulin Dependent Diabetes Mellitus, Type II / Diabetes Mellitus Type 2 / Type Two Diabetes Mellitus / T2DM (Type 2 Diabetes Mellitus) / Type-2-diabetes Mellitus / Diabetes mellitus -adult onset / Diabetes mellitus non insulin-dep / Maturity onset diabetes / Diabetes mellitus maturity onset

IndicationStatusPhase
DBCOND0029752 (Type 2 Diabetes Mellitus)Completed2
clinicaltrials.gov IdentifierTitlePurposeDrugs
NCT00698230Safety and Efficacy of INCB013739 Plus Metformin Compared to Metformin Alone on Glycemic Control in Type 2 DiabeticsTreatment
NCT00263276A Trial of BMS-512148 in Patients With Type 2 Diabetes MellitusTreatment
NCT00443755Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin ResistanceTreatment
NCT00871936A Comparison of SLx-4090 in Combination With Metformin Versus Metformin Therapy Alone in Patients With Type 2 DiabetesTreatment
NCT01969318Efficacy and Safety Study of SP2086 in Combination With Metformin in Patients With Type 2 DiabetesPrevention
NCT01117584A Study to Evaluate the Effect of ASP1941 in Combination With Metformin in Adult Patients With Type 2 Diabetes MellitusTreatment
NCT02973321A Study to Assess the Safety and Efficacy of SAR425899 in Patients With Type 2 Diabetes MellitusTreatment
NCT01217073A Dose-Range Finding Study in Participants With Type 2 Diabetes (MK-3102-006)Treatment
NCT02004886A Study to Assess the Safety, Tolerability and Glucose-Lowering Efficacy of MK-0893 in Participants With Type 2 Diabetes Mellitus (MK-0893-005)Treatment
NCT02091362A Study of LY2409021 on Blood Pressure and Pulse Rate in Participants With Type 2 Diabetes MellitusBasic Science
NCT01240759Safety and Efficacy of S-707106 in Subjects With Type 2 Diabetes Mellitus and Inadequate Glycemic Control With Metformin TherapyTreatment
NCT02151461Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic PatientsTreatment
NCT02435277An Extension Protocol to Evaluate Dose Comparisons of Leucine-Metformin Combinations in Type 2 Diabetic PatientsTreatment
NCT00110851Safety and Efficacy Study of PN2034 in Type 2 Diabetes Patients on Concomitant Rosiglitazone and Metformin (or Avandamet)Treatment
NCT00420511Beta-Cell Function and Sitagliptin Trial (BEST)Treatment
NCT00605475Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 in Patients With Type 2 DiabetesTreatment
NCT00792935A Study to Test MK-0941 in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-0941-017)Treatment
NCT00901979A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM)Treatment
NCT00971243Efficacy and Safety of MP-513 in Combination With Metformin in Patients With Type 2 DiabetesTreatment
NCT01068860To Compare the Effect of a Subcutaneous Canakinumab Administration to Placebo in Patients With Impaired Glucose Tolerance or Patients With Type 2 Diabetes With Differing Baseline Diabetes TherapiesTreatment
NCT01175473Effects of Lixisenatide Compared to Liraglutide on the Postprandial Plasma Glucose in Patients With Type 2 DiabetesTreatment
NCT01425580Liraglutide and Heart Failure in Type 2 DiabetesTreatment
NCT01476475Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Combination Versus Insulin Glargine Alone on Top of Metformin in Type 2 Diabetic PatientsTreatment
NCT01596504Pharmacodynamic Effects of Lixisenatide Compared to Liraglutide in Patients With Type 2 Diabetes Not Adequately Controlled With Insulin Glargine With or Without MetforminTreatment
NCT01658501Phase 2b Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Assess the PD Response and Safety of Three Dose Levels of (PB1023) Injection Following 20 Weeks of Weekly SC Dosing in Adults With T2DMTreatment
NCT02434744Study of KD026 in Combination With Metformin in Subjects With Type 2 Diabetes MellitusTreatment
NCT02205528A Study of Once-Daily NNC0090-2746 in Participants With Type 2 Diabetes Inadequately Controlled With MetforminTreatment
NCT01729403A Study of The Effect of Aleglitazar on Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled With MetforminTreatment
NCT00316758A Study to Evaluate the Long-Term Safety and Tolerability of GK Activator (2) in Patients With Type 2 Diabetes.Treatment
NCT00266253A Study of GK Activator (2) in Patients With Type 2 Diabetes Mellitus Treated With a Stable Dose of MetforminTreatment
NCT00111631A Study of DPP-IV Inhibitor in Patients With Type 2 DiabetesTreatment
NCT00454233A Safety and Efficacy Study With YM543 in Type 2 Diabetes Mellitus SubjectsTreatment
NCT01071850A Study to Evaluate the Effect of ASP1941 in Adult Patients With Type 2 Diabetes MellitusTreatment
NCT01059825Study Of Safety And Efficacy Of Ertugliflozin (PF-04971729, MK-8835) In Participants With Type 2 Diabetes (MK-8835-016)Treatment
NCT02500628Heart Rate Variability in Response to Metformin ChallengeDiagnostic
NCT02202161A Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 Administered With Metformin to Type 2 Diabetes PatientsTreatment
NCT01929863Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 in Type 2 Diabetes Patients Taking MetforminTreatment
NCT00631488A Study to Test the Effectiveness and Safety of MK0893 in Combination With Other Drugs Used to Treat Type 2 Diabetes (0893-015)Treatment
NCT01340664An Efficacy, Safety, and Tolerability Study of Canagliflozin in the Treatment of Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin MonotherapyTreatment
NCT00614055Comparison of Two NN5401 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 DiabetesTreatment
NCT00613951Comparison of Two NN5401 Formulations Versus Biphasic Insulin Aspart 30, All in Combination With Metformin in Subjects With Type 2 DiabetesTreatment
NCT01511198Efficacy and Safety of Metformin and Liraglutide in Obese Subjects With Type 2 Diabetes Previously Treated With an Oral Hypoglycemic AgentTreatment
NCT01511172Effect of Liraglutide as add-on to Metformin Compared to Either Liraglutide or Metformin Alone, or to a Combination of Metformin and a SU (Sulphonylurea) Agent in Subjects With Type 2 DiabetesTreatment
NCT00611884Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 DiabetesTreatment
NCT01935804Effect of Pioglitazone Versus Metformin on Bone Health in Postmenopausal Women With Type 2 DiabetesTreatment
NCT0078903512 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic PatientsTreatment
NCT00881530Empagliflozin (BI 10773) in Type Two Diabetes (T2D) Patients, Open Label ExtensionTreatment
NCT00290940Evaluation of Glucose Lowering Effect, Safety and Tolerability of CS-917Treatment
NCT00328172Efficacy and Safety of 3 Doses of BI1356 (Linagliptin) in Type 2 Diabetes PatientsTreatment
NCT00672386A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 DiabetesTreatment
NCT01111955Safety Study of BMS-823778 in Subjects With Type 2 DiabetesTreatment
NCT01046422Safety Study of BMS-770767 in Subjects With Type 2 DiabetesTreatment
NCT00481663A Study of Different Doses of Sitagliptin (MK-0431) in Participants With Type 2 Diabetes Mellitus (MK-0431-014)Treatment