Hot Flushes

Also known as: Hot Flashes / Hot flush / Hot Flash / Climacteric flushing / Menopause flushing / Hot flushes menopausal / Menopausal hot flushes / Feeling of hot flushes / Hot flushes, menopausal / Flush hot / Flash hot / Hot flushes NOS

DrugDrug NameDrug Description
DB00575ClonidineAn alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.
DB06700DesvenlafaxineAn antidepressant agent and SNRI used for the treatment of major depressive disorders in adults.
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB01323St. John's WortAn herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety.
DrugDrug NameTargetType
DB00575ClonidineAlpha-2A adrenergic receptortarget
DB00575ClonidineCytochrome P450 2D6enzyme
DB00575ClonidineAlpha-2B adrenergic receptortarget
DB00575ClonidineAlpha-2C adrenergic receptortarget
DB00575ClonidineSolute carrier family 22 member 3transporter
DB00575ClonidineSolute carrier family 22 member 5transporter
DB00575ClonidineSolute carrier family 22 member 4transporter
DB00575ClonidineP-glycoprotein 1transporter
DB00575ClonidineCytochrome P450 1A2enzyme
DB00575ClonidineCytochrome P450 3A4enzyme
DB00575ClonidineCytochrome P450 1A1enzyme
DB00575ClonidineCytochrome P450 3A5enzyme
DB00575ClonidineAlpha-1A adrenergic receptortarget
DB00575ClonidineAlpha-1B adrenergic receptortarget
DB00575ClonidineAlpha-1D adrenergic receptortarget
DB00575ClonidineSerum albumincarrier
DB06700DesvenlafaxineCytochrome P450 3A4enzyme
DB06700DesvenlafaxineSodium-dependent serotonin transportertarget
DB06700DesvenlafaxineSodium-dependent noradrenaline transportertarget
DB06700DesvenlafaxineCytochrome P450 2D6enzyme
DB06700DesvenlafaxineSodium-dependent dopamine transportertarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DB01323St. John's WortP-glycoprotein 1transporter
DB01323St. John's WortCytochrome P450 3A4enzyme
DB01323St. John's WortCytochrome P450 2D6enzyme
DB01323St. John's WortCytochrome P450 2C19enzyme
DrugDrug NamePhaseStatusCount
DB00297Bupivacaine0Completed1
DB13975Black cohosh1Terminated1
DB05052MF1011Unknown Status1
DB13975Black cohosh1 / 2Completed1
DB01065Melatonin1 / 2Terminated1
DB15458Norleucine1 / 2Completed1
DB13975Black cohosh2Completed2
DB13975Black cohosh2Withdrawn1
DB00297Bupivacaine2Active Not Recruiting1
DB00297Bupivacaine2Recruiting2
DB00575Clonidine2Active Not Recruiting1
DB00286Conjugated estrogens2Completed1
DB00080Daptomycin2Completed1
DB06374Elacestrant2Completed1
DB06374Elacestrant2Terminated1
DB12235Estetrol2Completed1
DB00783Estradiol2Completed1
DB13952Estradiol acetate2Completed1
DB15669Fezolinetant2Completed1
DB00996Gabapentin2Active Not Recruiting1
DB00996Gabapentin2Completed1
DB05052MF1012Completed1
DB01377Magnesium oxide2Completed2
DB00603Medroxyprogesterone acetate2Completed1
DB01062Oxybutynin2Completed1
DB15264PD-02996852Completed1
DB00715Paroxetine2Completed1
DB00734Risperidone2Recruiting1
DB09153Sodium chloride2Active Not Recruiting1
DB09153Sodium chloride2Recruiting1
DB01591Solifenacin2Active Not Recruiting1
DB01323St. John's Wort2Terminated1
DB00675Tamoxifen2Completed1
DB11558Toluene2Completed1
DB15530Trifolium pratense pollen2Completed1
DB01708Prasterone2 / 3Completed1
DB13975Black cohosh3Unknown Status1
DB00215Citalopram3Completed1
DB00286Conjugated estrogens3Completed1
DB04839Cyproterone acetate3Completed1
DB06700Desvenlafaxine3Completed1
DB01395Drospirenone3Completed1
DB00783Estradiol3Completed4
DB00783Estradiol3Recruiting1
DB15669Fezolinetant3Active Not Recruiting1
DB15669Fezolinetant3Recruiting4
DB00996Gabapentin3Completed7
DB00014Goserelin3Recruiting1
DB05052MF1013Unknown Status1
DB00603Medroxyprogesterone acetate3Completed2
DB00351Megestrol acetate3Completed1
DB01062Oxybutynin3Completed1
DB00715Paroxetine3Completed1
DB01708Prasterone3Completed1
DB00230Pregabalin3Completed1
DB00396Progesterone3Completed1
DB00391Sulpiride3Completed1
DB09317Synthetic Conjugated Estrogens, A3Completed1
DB00624Testosterone3Completed1
DB00285Venlafaxine3Completed1
DB00285Venlafaxine3Terminated1
DB00297Bupivacaine4Recruiting1
DB06700Desvenlafaxine4Terminated1
DB00783Estradiol4Completed1
DB00644Gonadorelin4Completed1
DB12007Isoflavone4Completed1
DB00007Leuprolide4Completed2
DB00367Levonorgestrel4Completed1
DB01224Quetiapine4Completed1
DB14101Soy isoflavones4Completed1
DB09068Vortioxetine4Completed1
DB13975Black cohoshNot AvailableCompleted1
DB00215CitalopramNot AvailableActive Not Recruiting1
DB00286Conjugated estrogensNot AvailableTerminated1
DB00286Conjugated estrogensNot AvailableUnknown Status1
DB01175EscitalopramNot AvailableActive Not Recruiting1
DB01175EscitalopramNot AvailableCompleted1
DB00783EstradiolNot AvailableCompleted1
DB00783EstradiolNot AvailableTerminated1
DB00783EstradiolNot AvailableUnknown Status1
DB00472FluoxetineNot AvailableEnrolling by Invitation1
DB00996GabapentinNot AvailableActive Not Recruiting1
DB00996GabapentinNot AvailableCompleted2
DB00715ParoxetineNot AvailableTerminated1
DB00396ProgesteroneNot AvailableCompleted1
DB00396ProgesteroneNot AvailableUnknown Status1
DB01104SertralineNot AvailableActive Not Recruiting1
DB00675TamoxifenNot AvailableActive Not Recruiting1
DB00285VenlafaxineNot AvailableActive Not Recruiting1
DB00285VenlafaxineNot AvailableCompleted2
DB00285VenlafaxineNot AvailableWithdrawn1
DB06684VilazodoneNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted1