Also known as: Plasma cell myeloma / Myelomas / Myelomatosis / Plasma cell myelomas / Myeloma / Myelomatosis multiple / Peripheral plasma cell myeloma / Multiple myeloma myelomatosis / Multiple myeloma with failed remission / Multiple Myeloma
DrugDrug NameDrug Description
DB09054IdelalisibIdelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies. More specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils. By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and adhesion, and reduced cell viability.
DrugDrug NamePhaseStatusCount
DB01234Dexamethasone0Active Not Recruiting1
DB01611Hydroxychloroquine0Completed1
DB12530Inebilizumab0Active Not Recruiting1
DB00480Lenalidomide0Active Not Recruiting1
DB00877Sirolimus0Completed1
DB00945Acetylsalicylic acid1Completed1
DB00087Alemtuzumab1Terminated1
DB01076Atorvastatin1Unknown Status1
DB00626Bacitracin1Completed1
DB00074Basiliximab1Recruiting1
DB06769Bendamustine1Active Not Recruiting1
DB06769Bendamustine1Completed1
DB00112Bevacizumab1Completed1
DB00188Bortezomib1Active Not Recruiting1
DB00188Bortezomib1Completed1
DB00188Bortezomib1Recruiting1
DB01008Busulfan1Completed1
DB08889Carfilzomib1Active Not Recruiting3
DB09110Coenzyme M1Terminated1
DB00531Cyclophosphamide1Recruiting1
DB00531Cyclophosphamide1Terminated1
DB00091Cyclosporine1Suspended1
DB01234Dexamethasone1Active Not Recruiting6
DB01234Dexamethasone1Completed1
DB01234Dexamethasone1Recruiting1
DB01234Dexamethasone1Terminated2
DB00099Filgrastim1Active Not Recruiting1
DB01073Fludarabine1Suspended1
DB01073Fludarabine1Terminated2
DB00441Gemcitabine1Completed1
DB00480Lenalidomide1Active Not Recruiting2
DB00480Lenalidomide1Completed2
DB00480Lenalidomide1Recruiting2
DB00480Lenalidomide1Terminated1
DB01042Melphalan1Completed1
DB01042Melphalan1Recruiting1
DB01042Melphalan1Terminated2
DB00688Mycophenolate mofetil1Suspended1
DB00994Neomycin1Completed1
DB00039Palifermin1Completed1
DB06603Panobinostat1Active Not Recruiting2
DB00019Pegfilgrastim1Recruiting1
DB06809Plerixafor1Recruiting1
DB00781Polymyxin B Sulfate1Completed1
DB08910Pomalidomide1Active Not Recruiting2
DB08910Pomalidomide1Terminated1
DB09345Pramocaine1Completed1
DB00073Rituximab1Completed1
DB00073Rituximab1Terminated1
DB00020Sargramostim1Recruiting1
DB00877Sirolimus1Terminated1
DB00755Tretinoin1Terminated1
DB04974AP19031 / 2Terminated1
DB00087Alemtuzumab1 / 2Active Not Recruiting1
DB00087Alemtuzumab1 / 2Terminated1
DB00026Anakinra1 / 2Active Not Recruiting1
DB01169Arsenic trioxide1 / 2Completed1
DB00188Bortezomib1 / 2Completed2
DB00188Bortezomib1 / 2Recruiting1
DB00188Bortezomib1 / 2Terminated1
DB01008Busulfan1 / 2Active Not Recruiting1
DB08889Carfilzomib1 / 2Completed1
DB00493Cefotaxime1 / 2Recruiting2
DB01211Clarithromycin1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Completed1
DB00531Cyclophosphamide1 / 2Recruiting2
DB01234Dexamethasone1 / 2Active Not Recruiting3
DB01234Dexamethasone1 / 2Completed2
DB01234Dexamethasone1 / 2Recruiting5
DB01234Dexamethasone1 / 2Terminated1
DB06317Elotuzumab1 / 2Recruiting2
DB00099Filgrastim1 / 2Recruiting3
DB09560Filgrastim1 / 2Recruiting1
DB00099Filgrastim1 / 2Terminated1
DB01073Fludarabine1 / 2Active Not Recruiting1
DB01073Fludarabine1 / 2Terminated2
DB09570Ixazomib1 / 2Active Not Recruiting1
DB09570Ixazomib1 / 2Recruiting2
DB00480Lenalidomide1 / 2Active Not Recruiting2
DB00480Lenalidomide1 / 2Completed2
DB00480Lenalidomide1 / 2Recruiting3
DB01042Melphalan1 / 2Completed3
DB01042Melphalan1 / 2Recruiting2
DB01042Melphalan1 / 2Terminated3
DB00959Methylprednisolone1 / 2Terminated1
DB00039Palifermin1 / 2Recruiting1
DB06603Panobinostat1 / 2Active Not Recruiting1
DB08910Pomalidomide1 / 2Completed1
DB08910Pomalidomide1 / 2Recruiting2
DB00635Prednisone1 / 2Completed1
DB09036Siltuximab1 / 2Completed1
DB00864Tacrolimus1 / 2Terminated1
DB01041Thalidomide1 / 2Active Not Recruiting1
DB04572Thiotepa1 / 2Terminated1
DB00126Vitamin C1 / 2Completed1
DB08916Afatinib2Recruiting1
DB00087Alemtuzumab2Terminated1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting2
DB06769Bendamustine2Withdrawn1
DB00188Bortezomib2Active Not Recruiting1
DB00188Bortezomib2Recruiting1
DB00188Bortezomib2Terminated1
DB00188Bortezomib2Unknown Status1
DB00188Bortezomib2Withdrawn2
DB01008Busulfan2Active Not Recruiting1
DB01008Busulfan2Completed1
DB01008Busulfan2Recruiting1
DB01008Busulfan2Withdrawn1
DB01197Captopril2Recruiting1
DB08889Carfilzomib2Withdrawn1
DB00493Cefotaxime2Recruiting2
DB00515Cisplatin2Recruiting1
DB00515Cisplatin2Withdrawn1
DB00631Clofarabine2Recruiting1
DB06189Clofarabine2Recruiting1
DB09110Coenzyme M2Recruiting1
DB08865Crizotinib2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Completed2
DB00531Cyclophosphamide2Recruiting5
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Unknown Status1
DB00531Cyclophosphamide2Withdrawn1
DB00091Cyclosporine2Active Not Recruiting1
DB00091Cyclosporine2Recruiting2
DB08912Dabrafenib2Recruiting1
DB09331Daratumumab2Not Yet Recruiting1
DB09331Daratumumab2Recruiting1
DB01254Dasatinib2Recruiting1
DB01254Dasatinib2Terminated1
DB12282Defactinib2Recruiting1
DB01234Dexamethasone2Active Not Recruiting4
DB01234Dexamethasone2Not Yet Recruiting1
DB01234Dexamethasone2Recruiting4
DB01234Dexamethasone2Unknown Status1
DB01234Dexamethasone2Withdrawn2
DB00514Dextromethorphan2Recruiting1
DB00586Diclofenac2Withdrawn1
DB01075Diphenhydramine2Recruiting2
DB00997Doxorubicin2Recruiting1
DB00997Doxorubicin2Withdrawn1
DB06317Elotuzumab2Recruiting1
DB00773Etoposide2Recruiting1
DB00773Etoposide2Withdrawn1
DB00927Famotidine2Recruiting1
DB00099Filgrastim2Active Not Recruiting3
DB00099Filgrastim2Completed1
DB00099Filgrastim2Recruiting1
DB00099Filgrastim2Terminated1
DB01073Fludarabine2Completed1
DB01073Fludarabine2Recruiting5
DB01073Fludarabine2Terminated1
DB00441Gemcitabine2Active Not Recruiting1
DB00441Gemcitabine2Withdrawn1
DB09570Ixazomib2Active Not Recruiting1
DB09570Ixazomib2Not Yet Recruiting1
DB09570Ixazomib2Recruiting3
DB00130L-Glutamine2Withdrawn1
DB00480Lenalidomide2Active Not Recruiting3
DB00480Lenalidomide2Not Yet Recruiting1
DB00480Lenalidomide2Recruiting4
DB00480Lenalidomide2Withdrawn1
DB01042Melphalan2Active Not Recruiting2
DB01042Melphalan2Completed1
DB01042Melphalan2Recruiting4
DB01042Melphalan2Terminated2
DB01042Melphalan2Withdrawn2
DB00563Methotrexate2Terminated1
DB00959Methylprednisolone2Recruiting1
DB00959Methylprednisolone2Withdrawn1
DB01017Minocycline2Active Not Recruiting2
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Recruiting5
DB00688Mycophenolate mofetil2Terminated1
DB01024Mycophenolic acid2Recruiting1
DB01024Mycophenolic acid2Terminated1
DB00220Nelfinavir2Active Not Recruiting1
DB09035Nivolumab2Recruiting1
DB09330Osimertinib2Recruiting1
DB09073Palbociclib2Recruiting1
DB00039Palifermin2Active Not Recruiting1
DB00039Palifermin2Withdrawn1
DB00019Pegfilgrastim2Completed1
DB00019Pegfilgrastim2Unknown Status1
DB09037Pembrolizumab2Active Not Recruiting1
DB00299Penciclovir2Active Not Recruiting1
DB00552Pentostatin2Active Not Recruiting1
DB06366Pertuzumab2Recruiting1
DB06809Plerixafor2Active Not Recruiting1
DB06809Plerixafor2Completed2
DB06809Plerixafor2Recruiting1
DB08910Pomalidomide2Recruiting1
DB00635Prednisone2Terminated1
DB00165Pyridoxine2Withdrawn1
DB10415Rabbit2Recruiting2
DB00863Ranitidine2Recruiting1
DB00073Rituximab2Recruiting1
DB00020Sargramostim2Recruiting1
DB00020Sargramostim2Terminated1
DB00641Simvastatin2Withdrawn1
DB00877Sirolimus2Recruiting1
DB01268Sunitinib2Recruiting1
DB00864Tacrolimus2Recruiting3
DB00864Tacrolimus2Terminated2
DB01041Thalidomide2Active Not Recruiting1
DB01041Thalidomide2Recruiting1
DB01041Thalidomide2Withdrawn1
DB01030Topotecan2Completed1
DB08911Trametinib2Recruiting1
DB05773Trastuzumab emtansine2Recruiting1
DB00361Vinorelbine2Completed1
DB08828Vismodegib2Recruiting1
DB02546Vorinostat2Withdrawn1
DB01593Zinc2Recruiting1
DB00399Zoledronic acid2Withdrawn1
DB06605Apixaban3Recruiting1
DB00188Bortezomib3Active Not Recruiting1
DB01008Busulfan3Active Not Recruiting1
DB08889Carfilzomib3Not Yet Recruiting1
DB00091Cyclosporine3Active Not Recruiting1
DB01234Dexamethasone3Completed1
DB01234Dexamethasone3Not Yet Recruiting1
DB01234Dexamethasone3Recruiting1
DB00997Doxorubicin3Completed1
DB00099Filgrastim3Active Not Recruiting1
DB01073Fludarabine3Active Not Recruiting1
DB00480Lenalidomide3Active Not Recruiting2
DB01042Melphalan3Active Not Recruiting1
DB00688Mycophenolate mofetil3Active Not Recruiting1
DB08910Pomalidomide3Recruiting1
DB00541Vincristine3Completed1
DB01008Busulfan4Completed1
DB01073Fludarabine4Completed1
DB00125L-Arginine4Completed1
DB00480LenalidomideNot AvailableTerminated1
DB06809PlerixaforNot AvailableCompleted1
DB01041ThalidomideNot AvailableTerminated1