Opioid Dependence

Also known as: Opioid type dependence, unspecified use / Unspecified opioid dependence / Opiate Dependence / Dependence on opiates / Opioid type dependence

DrugDrug NameDrug Description
DB00921BuprenorphineA partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.
DB01183NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
DB00704NaltrexoneA narcotic antagonist used in opioid overdose.
DrugDrug NameTargetType
DB00921BuprenorphineKappa-type opioid receptortarget
DB00921BuprenorphineMu-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 3A4enzyme
DB00921BuprenorphineCytochrome P450 2D6enzyme
DB00921BuprenorphineP-glycoprotein 1transporter
DB00921BuprenorphineATP-binding cassette sub-family G member 2transporter
DB00921BuprenorphineCytochrome P450 2C9enzyme
DB00921BuprenorphineCytochrome P450 3A5enzyme
DB00921BuprenorphineCytochrome P450 2C8enzyme
DB00921BuprenorphineCytochrome P450 3A7enzyme
DB00921BuprenorphineDelta-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 2C18enzyme
DB00921BuprenorphineCytochrome P450 2C19enzyme
DB00921BuprenorphineNociceptin receptortarget
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneP-glycoprotein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DB00704NaltrexoneMu-type opioid receptortarget
DB00704NaltrexoneKappa-type opioid receptortarget
DB00704NaltrexoneDelta-type opioid receptortarget
DB00704NaltrexoneHCG20471, isoform CRA_ctarget
DB00704NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
DrugDrug NamePhaseStatusCount
DB00497Oxycodone0Recruiting1
DB00107Oxytocin0Completed1
DB00734Risperidone0Recruiting1
DB00246Ziprasidone0Recruiting1
DB00673Aprepitant1Completed1
DB00921Buprenorphine1Completed3
DB00260Cycloserine1Completed1
DB00343Diltiazem1Completed1
DB00996Gabapentin1Completed1
DB00327Hydromorphone1Completed1
DB00270Isradipine1Completed1
DB04948Lofexidine1Completed3
DB04871Lorcaserin1Completed1
DB00333Methadone1Completed3
DB01183Naloxone1Completed2
DB00704Naltrexone1Completed2
DB01115Nifedipine1Completed1
DB01273Varenicline1Completed1
DB00661Verapamil1Completed1
DB00921Buprenorphine1 / 2Active Not Recruiting1
DB00921Buprenorphine1 / 2Completed1
DB00921Buprenorphine1 / 2Recruiting1
DB00575Clonidine1 / 2Completed1
DB00270Isradipine1 / 2Completed1
DB14158Microcrystalline cellulose1 / 2Completed1
DB00295Morphine1 / 2Active Not Recruiting1
DB01183Naloxone1 / 2Completed1
DB01183Naloxone1 / 2Recruiting1
DB00704Naltrexone1 / 2Completed1
DB00107Oxytocin1 / 2Enrolling by Invitation1
DB00193Tramadol1 / 2Completed1
DB00921Buprenorphine2Completed4
DB00907Cocaine2Completed1
DB00822Disulfiram2Completed1
DB00996Gabapentin2Completed2
DB00741Hydrocortisone2Completed1
DB05266Ibudilast2Active Not Recruiting1
DB01202Levetiracetam2Completed1
DB00742Mannitol2Completed1
DB01043Memantine2Completed1
DB00333Methadone2Completed2
DB01183Naloxone2Completed2
DB00704Naltrexone2Completed3
DB00860Prednisolone2Terminated1
DB09034Suvorexant2Recruiting1
DB00297Bupivacaine2 / 3Not Yet Recruiting1
DB00921Buprenorphine2 / 3Completed3
DB00470Dronabinol2 / 3Completed1
DB00668Epinephrine2 / 3Not Yet Recruiting1
DB01043Memantine2 / 3Completed2
DB00333Methadone2 / 3Completed1
DB01183Naloxone2 / 3Completed2
DB00704Naltrexone2 / 3Completed2
DB00921Buprenorphine3Completed7
DB00921Buprenorphine3Recruiting1
DB00921Buprenorphine3Terminated1
DB00921Buprenorphine3Withdrawn2
DB01156Bupropion3Not Yet Recruiting1
DB01452Diamorphine3Completed2
DB00327Hydromorphone3Completed1
DB04948Lofexidine3Completed1
DB00333Methadone3Completed4
DB00295Morphine3Completed1
DB01183Naloxone3Completed3
DB01183Naloxone3Withdrawn2
DB00704Naltrexone3Completed1
DB11130Opium3Completed1
DB00297Bupivacaine4Recruiting1
DB00921Buprenorphine4Completed2
DB00921Buprenorphine4Not Yet Recruiting1
DB00921Buprenorphine4Recruiting1
DB00921Buprenorphine4Unknown Status1
DB09065Cobicistat4Recruiting1
DB06700Desvenlafaxine4Completed1
DB09101Elvitegravir4Recruiting1
DB00879Emtricitabine4Recruiting1
DB00996Gabapentin4Completed1
DB00951Isoniazid4Recruiting1
DB00825Levomenthol4Not Yet Recruiting1
DB00281Lidocaine4Not Yet Recruiting1
DB00333Methadone4Recruiting1
DB01183Naloxone4Completed1
DB01183Naloxone4Not Yet Recruiting1
DB01183Naloxone4Recruiting1
DB01183Naloxone4Unknown Status1
DB00704Naltrexone4Active Not Recruiting1
DB00704Naltrexone4Completed1
DB00704Naltrexone4Recruiting1
DB01201Rifapentine4Recruiting1
DB08934Sofosbuvir4Recruiting1
DB09299Tenofovir alafenamide4Recruiting1
DB11613Velpatasvir4Recruiting1
DB00813FentanylNot AvailableUnknown Status1
DB01017MinocyclineNot AvailableCompleted1
DB00704NaltrexoneNot AvailableCompleted1
DB00759TetracyclineNot AvailableCompleted1