Advanced Breast Cancer

Also known as: Malignant neoplasm of breast / Malignant breast neoplasm / Breast cancer / Breast tumor malignant / Breast tumour malignant / Breast cancer NOS / Breast cancer stage unspecified / Ca breast

DrugDrug NameDrug Description
DB12001AbemaciclibA medication used to treat HR+ HER2- advanced or metastatic breast cancer.
DB01217AnastrozoleA competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
DB00014GoserelinA synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary.
DB01006LetrozoleAn aromatase inhibitor used to treat breast cancer in postmenopausal women.
DB00351Megestrol acetateA progestin that is administered orally to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.
DB09073PalbociclibAn endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer.
DB11730RibociclibA kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer.
DrugDrug NameTargetType
DB12001AbemaciclibMultidrug and toxin extrusion protein 1transporter
DB12001AbemaciclibMultidrug and toxin extrusion protein 2transporter
DB12001AbemaciclibCyclin-dependent kinase 4target
DB12001AbemaciclibCyclin-dependent kinase 6target
DB12001AbemaciclibSerum albumincarrier
DB12001Abemaciclibalpha1-acid glycoproteincarrier
DB12001AbemaciclibCytochrome P450 3A4enzyme
DB12001AbemaciclibP-glycoprotein 1transporter
DB12001AbemaciclibATP-binding cassette sub-family G member 2transporter
DB12001AbemaciclibSolute carrier family 22 member 2transporter
DB12001AbemaciclibCytochrome P450 1A2enzyme
DB12001AbemaciclibCytochrome P450 2B6enzyme
DB12001AbemaciclibCytochrome P450 2C8enzyme
DB12001AbemaciclibCytochrome P450 2C9enzyme
DB12001AbemaciclibCytochrome P450 2D6enzyme
DB01217AnastrozoleCytochrome P450 19A1target
DB01217AnastrozoleP-glycoprotein 1transporter
DB01217AnastrozoleCytochrome P450 3A4enzyme
DB01217AnastrozoleCytochrome P450 3A5enzyme
DB01217AnastrozoleCytochrome P450 2C8enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 1-4enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 1-3enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 2B7enzyme
DB01217AnastrozoleCytochrome P450 1A2enzyme
DB01217AnastrozoleCytochrome P450 2C9enzyme
DB00014GoserelinLutropin-choriogonadotropic hormone receptortarget
DB00014GoserelinGonadotropin-releasing hormone receptortarget
DB01006LetrozoleCytochrome P450 19A1target
DB01006LetrozoleCytochrome P450 3A4enzyme
DB01006LetrozoleCytochrome P450 2A6enzyme
DB01006LetrozoleCytochrome P450 19A1enzyme
DB00351Megestrol acetateProgesterone receptortarget
DB00351Megestrol acetateGlucocorticoid receptortarget
DB00351Megestrol acetateP-glycoprotein 1transporter
DB00351Megestrol acetateCytochrome P450 3A4enzyme
DB09073PalbociclibCyclin-dependent kinase 4target
DB09073PalbociclibCyclin-dependent kinase 6target
DB09073PalbociclibCytochrome P450 3A4enzyme
DB09073PalbociclibBile salt sulfotransferaseenzyme
DB09073PalbociclibP-glycoprotein 1transporter
DB09073PalbociclibATP-binding cassette sub-family G member 2transporter
DB09073PalbociclibSerum albumincarrier
DB09073PalbociclibSolute carrier family 22 member 1transporter
DB11730RibociclibCyclin-dependent kinase 4target
DB11730RibociclibCyclin-dependent kinase 6target
DB11730RibociclibCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB01101Capecitabine1Completed1
DB01254Dasatinib1Completed1
DB01262Decitabine1Active Not Recruiting1
DB01248Docetaxel1Completed1
DB00990Exemestane1Recruiting1
DB00947Fulvestrant1Completed1
DB00947Fulvestrant1Not Yet Recruiting1
DB01006Letrozole1Active Not Recruiting1
DB12852MK-07521Completed1
DB09074Olaparib1Not Yet Recruiting1
DB01229Paclitaxel1Active Not Recruiting1
DB01229Paclitaxel1Recruiting1
DB01229Paclitaxel1Unknown Status1
DB09073Palbociclib1Active Not Recruiting1
DB09073Palbociclib1Not Yet Recruiting1
DB09073Palbociclib1Recruiting1
DB11730Ribociclib1Recruiting1
DB09143Sonidegib1Completed1
DB05773Trastuzumab emtansine1Recruiting1
DB02546Vorinostat1Completed1
DB08916Afatinib1 / 2Recruiting1
DB01217Anastrozole1 / 2Recruiting1
DB01101Capecitabine1 / 2Recruiting1
DB00947Fulvestrant1 / 2Recruiting1
DB01259Lapatinib1 / 2Recruiting1
DB01006Letrozole1 / 2Recruiting1
DB11828Neratinib1 / 2Completed2
DB11793Niraparib1 / 2Active Not Recruiting1
DB01229Paclitaxel1 / 2Completed1
DB09037Pembrolizumab1 / 2Active Not Recruiting1
DB12275Seviteronel1 / 2Completed1
DB11760Talazoparib1 / 2Recruiting1
DB00072Trastuzumab1 / 2Completed1
DB12218AZD-53632Recruiting1
DB06616Bosutinib2Terminated1
DB01101Capecitabine2Completed1
DB01101Capecitabine2Terminated1
DB01101Capecitabine2Unknown Status1
DB04849Cediranib2Completed1
DB14917Ceralasertib2Recruiting1
DB00515Cisplatin2Unknown Status1
DB11672Curcumin2Recruiting1
DB01254Dasatinib2Completed2
DB01234Dexamethasone2Completed1
DB01248Docetaxel2Completed1
DB00997Doxorubicin2Recruiting1
DB08899Enzalutamide2Active Not Recruiting1
DB01590Everolimus2Completed1
DB01590Everolimus2Recruiting1
DB00990Exemestane2Completed1
DB00990Exemestane2Recruiting1
DB00990Exemestane2Terminated1
DB00947Fulvestrant2Completed4
DB00947Fulvestrant2Recruiting2
DB00441Gemcitabine2Active Not Recruiting1
DB00014Goserelin2Completed1
DB01259Lapatinib2Completed1
DB01259Lapatinib2Terminated1
DB12984Larotaxel2Completed1
DB01006Letrozole2Recruiting1
DB00218Moxifloxacin2Completed1
DB11828Neratinib2Completed2
DB11828Neratinib2Recruiting1
DB09074Olaparib2Recruiting3
DB01229Paclitaxel2Completed1
DB01229Paclitaxel2Recruiting1
DB09073Palbociclib2Recruiting1
DB09037Pembrolizumab2Active Not Recruiting1
DB11760Talazoparib2Recruiting1
DB00072Trastuzumab2Active Not Recruiting1
DB00072Trastuzumab2Completed2
DB00072Trastuzumab2Recruiting1
DB05294Vandetanib2Completed1
DB01217Anastrozole3Completed2
DB01217Anastrozole3Not Yet Recruiting1
DB01248Docetaxel3Withdrawn1
DB11841Entinostat3Recruiting1
DB00990Exemestane3Recruiting1
DB00947Fulvestrant3Active Not Recruiting1
DB00947Fulvestrant3Completed2
DB00441Gemcitabine3Terminated1
DB00441Gemcitabine3Unknown Status1
DB00014Goserelin3Not Yet Recruiting1
DB01006Letrozole3Not Yet Recruiting1
DB01229Paclitaxel3Terminated1
DB01229Paclitaxel3Unknown Status1
DB06366Pertuzumab3Withdrawn1
DB11730Ribociclib3Active Not Recruiting1
DB00072Trastuzumab3Withdrawn1
DB11641Vinflunine3Terminated1
DB00361Vinorelbine3Withdrawn1
DB01217AnastrozoleNot AvailableCompleted1
DB08871EribulinNot AvailableRecruiting1
DB09073PalbociclibNot AvailableCompleted1
DB01268SunitinibNot AvailableCompleted1