Chronic Myeloid Leukemia - Accelerated Phase

Also known as: Accelerated phase chronic myologenic leukaemia / Chronic Myelogenous Leukemia, Accelerated Phase / Accelerated phase chronic myologenic leukemia / Accelerated Phase Chronic Myelogenous Leukemia / Accelerated Phase Chronic Myelogenous Leukemia (CML) / Accelerated Phase Chronic Myeloid Leukemia / Leukemia, Myeloid, Accelerated-Phase / Leukemia, Myeloid, Accelerated Phase / Accelerated phase chronic myeloid leukemia (disorder) / Chronic myeloid leukaemia / Leukemia myelocytic chronic / Leukaemia myelocytic chronic / Chronic granulocytic leukaemia / Chronic myelogenous leukaemia / Myeloid leukemia, chronic / Chronic myelogenous leukemia / Chronic granulocytic leukemia / Myeloid leukaemia, chronic / CML / Chronic myelocytic leukaemia / Chronic myelocytic leukemia / Chronic myeloid leukemia / Leukaemias chronic myeloid / Chronic myeloid leukemia, BCR/ABL-positive / Chronic myeloid leukemia (disorder) / Chronic myeloid leukemia (morphologic abnormality) / Leukemia, Myelogenous, Chronic, BCR-ABL Positive

DrugDrug NameDrug Description
DB06616BosutinibAn antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
DB01254DasatinibA tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia.
DB00619ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DB04868NilotinibA kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
DB08901PonatinibA kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).
DrugDrug NameTargetType
DB06616BosutinibTyrosine-protein kinase ABL1target
DB06616BosutinibTyrosine-protein kinase Lyntarget
DB06616BosutinibProto-oncogene tyrosine-protein kinase Srctarget
DB06616BosutinibP-glycoprotein 1transporter
DB06616BosutinibCytochrome P450 3A4enzyme
DB06616BosutinibDual specificity mitogen-activated protein kinase kinase 1target
DB06616BosutinibDual specificity mitogen-activated protein kinase kinase 2target
DB06616BosutinibMitogen-activated protein kinase kinase kinase 2target
DB06616BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
DB06616BosutinibCytochrome P450 2C8enzyme
DB06616BosutinibTyrosine-protein kinase Fgrtarget
DB06616BosutinibTyrosine-protein kinase HCKtarget
DB06616BosutinibTyrosine-protein kinase Tectarget
DB06616BosutinibSTE20-like serine/threonine-protein kinasetarget
DB01254DasatinibTyrosine-protein kinase ABL1target
DB01254DasatinibTyrosine-protein kinase ABL2target
DB01254DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DB01254DasatinibTyrosine-protein kinase Fyntarget
DB01254DasatinibTyrosine-protein kinase Lcktarget
DB01254DasatinibTyrosine-protein kinase Yestarget
DB01254DasatinibMast/stem cell growth factor receptor Kittarget
DB01254DasatinibPlatelet-derived growth factor receptor betatarget
DB01254DasatinibEphrin type-A receptor 2target
DB01254DasatinibSignal transducer and activator of transcription 5Btarget
DB01254DasatinibCytochrome P450 3A4enzyme
DB01254DasatinibP-glycoprotein 1transporter
DB01254DasatinibATP-binding cassette sub-family G member 2transporter
DB01254DasatinibCytochrome P450 1A1enzyme
DB01254DasatinibCytochrome P450 1A2enzyme
DB01254DasatinibCytochrome P450 1B1enzyme
DB01254DasatinibCytochrome P450 3A5enzyme
DB01254DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB01254DasatinibTyrosine-protein kinase BTKtarget
DB01254DasatinibNuclear receptor subfamily 4 group A member 3target
DB01254DasatinibBreakpoint cluster region proteintarget
DB01254DasatinibTyrosine-protein kinase CSKtarget
DB01254DasatinibEphrin type-A receptor 5target
DB01254DasatinibEphrin type-B receptor 4target
DB01254DasatinibTyrosine-protein kinase Fgrtarget
DB01254DasatinibTyrosine-protein kinase FRKtarget
DB01254DasatinibHeat shock cognate 71 kDa proteintarget
DB01254DasatinibTyrosine-protein kinase Lyntarget
DB01254DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DB01254DasatinibMitogen-activated protein kinase 14target
DB01254DasatinibAmidophosphoribosyltransferasetarget
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBreakpoint cluster region proteintarget
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibP-glycoprotein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00619ImatinibCytochrome P450 2C8enzyme
DB00619ImatinibCanalicular multispecific organic anion transporter 1transporter
DB00619ImatinibMultidrug resistance-associated protein 1transporter
DB00619ImatinibSolute carrier family 22 member 5transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1B3transporter
DB00619ImatinibMultidrug resistance-associated protein 4transporter
DB00619ImatinibSolute carrier organic anion transporter family member 1A2transporter
DB00619ImatinibDiscoidin domain-containing receptor 2target
DB04868NilotinibTyrosine-protein kinase ABL1target
DB04868NilotinibMast/stem cell growth factor receptor Kittarget
DB04868NilotinibCytochrome P450 2D6enzyme
DB04868NilotinibCytochrome P450 2C8enzyme
DB04868NilotinibCytochrome P450 2C9enzyme
DB04868NilotinibCytochrome P450 3A4enzyme
DB04868NilotinibP-glycoprotein 1transporter
DB04868NilotinibATP-binding cassette sub-family G member 2transporter
DB04868NilotinibUDP-glucuronosyltransferase 1-1transporter
DB04868NilotinibCytochrome P450 2B6enzyme
DB04868NilotinibSolute carrier organic anion transporter family member 1B1transporter
DB08901PonatinibTyrosine-protein kinase ABL1target
DB08901PonatinibBreakpoint cluster region proteintarget
DB08901PonatinibMast/stem cell growth factor receptor Kittarget
DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08901PonatinibAngiopoietin-1 receptortarget
DB08901PonatinibReceptor-type tyrosine-protein kinase FLT3target
DB08901PonatinibCytochrome P450 3A4enzyme
DB08901PonatinibCytochrome P450 2C8enzyme
DB08901PonatinibCytochrome P450 2D6enzyme
DB08901PonatinibCytochrome P450 3A5enzyme
DB08901PonatinibP-glycoprotein 1transporter
DB08901PonatinibATP-binding cassette sub-family G member 2transporter
DB08901PonatinibFibroblast growth factor receptor 1target
DB08901PonatinibFibroblast growth factor receptor 2target
DB08901PonatinibFibroblast growth factor receptor 3target
DB08901PonatinibFibroblast growth factor receptor 4target
DB08901PonatinibTyrosine-protein kinase Lcktarget
DB08901PonatinibProto-oncogene tyrosine-protein kinase Srctarget
DB08901PonatinibTyrosine-protein kinase Lyntarget
DB08901PonatinibVascular endothelial growth factor receptor 2target
DB08901PonatinibPlatelet-derived growth factor receptor alphatarget
DrugDrug NamePhaseStatusCount
DB019337-Hydroxystaurosporine1Completed1
DB06626Axitinib1Terminated1
DB06616Bosutinib1Terminated1
DB11752Bryostatin 11Completed1
DB00531Cyclophosphamide1Completed1
DB00091Cyclosporine1Completed1
DB00091Cyclosporine1Terminated1
DB00987Cytarabine1Completed3
DB01254Dasatinib1Completed1
DB01254Dasatinib1Terminated1
DB00773Etoposide1Completed1
DB01073Fludarabine1Completed1
DB00619Imatinib1Completed1
DB00619Imatinib1Terminated1
DB14123Menthol1Terminated1
DB00688Mycophenolate mofetil1Completed1
DB06641Perifosine1Completed1
DB00020Sargramostim1Completed1
DB01268Sunitinib1Completed1
DB06398Tanespimycin1Completed1
DB06287Temsirolimus1Terminated1
DB11940Triapine1Completed1
DB02546Vorinostat1Completed1
DB00041Aldesleukin1 / 2Terminated1
DB06616Bosutinib1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00091Cyclosporine1 / 2Completed1
DB00091Cyclosporine1 / 2Recruiting1
DB01073Fludarabine1 / 2Completed1
DB00619Imatinib1 / 2Completed1
DB17475Incomplete Freund's adjuvant1 / 2Completed1
DB00563Methotrexate1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Completed1
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB04868Nilotinib1 / 2Completed2
DB15276PR1 leukemia peptide vaccine1 / 2Completed1
DB08901Ponatinib1 / 2Recruiting1
DB08877Ruxolitinib1 / 2Completed1
DB00020Sargramostim1 / 2Completed1
DB00864Tacrolimus1 / 2Recruiting1
DB17459Therapeutic allogeneic lymphocytes1 / 2Terminated1
DB02546Vorinostat1 / 2Recruiting1
DB025942'-Deoxycytidine2Completed1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB09312Antilymphocyte immunoglobulin (horse)2Terminated1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Terminated1
DB00394Beclomethasone dipropionate2Completed1
DB01008Busulfan2Completed3
DB01008Busulfan2Terminated1
DB00531Cyclophosphamide2Completed4
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Withdrawn1
DB00091Cyclosporine2Completed4
DB01262Decitabine2Completed1
DB01262Decitabine2Recruiting1
DB01609Deferasirox2Terminated1
DB00005Etanercept2Completed1
DB01073Fludarabine2Completed8
DB01073Fludarabine2Terminated1
DB01073Fludarabine2Withdrawn1
DB16185HQP13512Active Not Recruiting1
DB16185HQP13512Recruiting1
DB00619Imatinib2Completed1
DB00619Imatinib2Terminated1
DB01042Melphalan2Completed1
DB00563Methotrexate2Completed6
DB00959Methylprednisolone2Completed2
DB14644Methylprednisolone hemisuccinate2Completed1
DB00688Mycophenolate mofetil2Completed4
DB00688Mycophenolate mofetil2Terminated1
DB00688Mycophenolate mofetil2Withdrawn1
DB04865Omacetaxine mepesuccinate2Terminated1
DB00904Ondansetron2Completed1
DB00073Rituximab2Terminated1
DB00877Sirolimus2Terminated1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Completed7
DB00864Tacrolimus2Terminated2
DB00864Tacrolimus2Withdrawn1
DB17459Therapeutic allogeneic lymphocytes2Completed1
DB11678Treosulfan2Completed1
DB11940Triapine2Completed1
DB02546Vorinostat2Completed1
DB01254Dasatinib3Completed1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableCompleted1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB00091CyclosporineNot AvailableCompleted2
DB00099FilgrastimNot AvailableTerminated1
DB01073FludarabineNot AvailableCompleted3
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB14509Lithium carbonateNot AvailableCompleted1
DB01042MelphalanNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableCompleted2
DB00039PaliferminNot AvailableCompleted1
DB06809PlerixaforNot AvailableTerminated1
DB17459Therapeutic allogeneic lymphocytesNot AvailableCompleted1
DB01610ValganciclovirNot AvailableCompleted1