Oral Mucositis

Also known as: Oral mucositis / Mucositis oral / Oral Mucositides / Stomatitis NOS / Stomatitis

DrugDrug NameDrug Description
DB01075DiphenhydramineDiphenhydramine, also known commercially as Benadryl, is a first generation antihistamine that is used primarily for the treatment of seasonal allergies. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system. While its use in in allergies has largely fallen out of favour due to this sedative effect, diphenhydramine has been repurposed for use within many OTC (over the counter) cough-and-cold medications that have been marketed for "night time" use. Diphenhydramine is also used in combination with [DB14132] as the anti-nausea drug [DB00985] where it is utilized primarily for its antagonism of H1 histamine receptors within the vestibular system [A1540]. Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid [A1539]. As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
DB00039PaliferminPalifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli.
DrugDrug NamePhaseStatusCount
DB00316Acetaminophen1Active Not Recruiting1
DB11073Cetylpyridinium1Active Not Recruiting1
DB00813Fentanyl1Active Not Recruiting1
DB01109Heparin1Completed1
DB00956Hydrocodone1Active Not Recruiting1
DB00039Palifermin1Completed2
DB01065Melatonin1 / 2Completed1
DB05436Acetylcysteine2Completed1
DB01025Amlexanox2Completed1
DB00126Ascorbic acid2Completed1
DB00482Celecoxib2Completed1
DB00515Cisplatin2Completed1
DB00515Cisplatin2Recruiting1
DB10672Clove2Completed1
DB05514Cobiprostone2Terminated1
DB00997Doxorubicin2Completed1
DB11879Dusquetide2Active Not Recruiting1
DB09462Glycerin2Completed1
DB05475Golotimod2Completed1
DB05475Golotimod2Unknown Status1
DB01181Ifosfamide2Completed1
DB00125L-Arginine2Completed1
DB00281Lidocaine2Completed1
DB05709Meclocycline2Completed1
DB06798Meclocycline2Completed1
DB00039Palifermin2Completed1
DB11252Poloxamer 4072Completed1
DB00860Prednisolone2Active Not Recruiting1
DB12060RRx-0012Recruiting1
DB09153Sodium Chloride2Terminated1
DB01390Sodium bicarbonate2Recruiting1
DB11251Tocopherol2Withdrawn1
DB06493Velafermin2Completed1
DB00541Vincristine2Completed1
DB09145Water2Completed1
DB11195Xylitol2Completed1
DB00126Ascorbic acid2 / 3Recruiting1
DB01593Zinc2 / 3Recruiting1
DB11879Dusquetide3Recruiting1
DB09484Sodium fluorophosphate3Recruiting1
DB01143Amifostine4Suspended1
DB00626Bacitracin4Recruiting1
DB00878Chlorhexidine4Completed1
DB11386Chlorobutanol4Completed1
DB08958Hexetidine4Completed1
DB01390Sodium bicarbonate4Enrolling by Invitation1
DB00878ChlorhexidineNot AvailableCompleted1