Hypogonadotrophic Hypogonadism

Also known as: Hypogonadotropic Hypogonadism / Kallman syndrome / Fertile eunuch syndrome / Secondary hypogonadism / Gonadotrophin deficiency

DrugDrug NameDrug Description
DB13943Testosterone cypionateTestosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. The characteristics of testosterone cypionate and testosterone enanthate are very similar, therefore both of them tend to be interchangeable.[L1152] It was developed by the company Pharmacia and Upjohn and FDA approved on July 25, 1979.
DB13944Testosterone enanthateTestosterone enanthate is an esterified variant of testosterone that comes as an injectable compound with a slow release rate. It is the first injectable ester preparation of testosterone.[L1158] This slow release is achieved by the presence of the enanthate ester functional group attached to the testosterone molecule.[A31615] This testosterone derivative was developed by Watson pharms Inc and FDA first approved on October 12, 1980. In 2017, about 6.5 million retail prescriptions for testosterone therapy were filled [L4659]. The majority of the prescriptions written were for injectable (66%) and topical (32%) testosterone products. As recent as 1 October 2018, the US FDA approved Antares Pharma Inc.'s Xyosted - a subcutaneous testosterone enanthate product for once-weekly, at-home self-administration with an easy-to-use, single dose, disposable autoinjector [L4659]. As the first subcutaneous autoinjector product designed for testosterone replacement therapy, this innovative formulation removes transfer concerns commonly associated with testosterone gels and potentially reduces the need for in-office/in-clinic injection procedures that may inconvenience patients with frequent visits to the clinic [L4659].
DB13946Testosterone undecanoateTestosterone undecanoate is the ester prodrug of testosterone and has a midchain fatty acid at the 17Beta position. [A176753] It is available as an intramuscular injection and as an oral capsule, and is indicated for treatment of testosterone deficiency. [F4247][FDA Label] It should be noted that testosterone undecanoate is only indicated for treatment of hypogonadal conditions with structural or genetic etiologies and should not be used to manage "age-related hypogonadism". [FDA Label]
DrugDrug NameTargetType
DB13943Testosterone cypionateAndrogen receptortarget
DB13943Testosterone cypionateCytochrome P450 3A4enzyme
DB13943Testosterone cypionateAmine oxidase [flavin-containing] Aenzyme
DB13943Testosterone cypionateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB13943Testosterone cypionateSerum albumincarrier
DB13943Testosterone cypionateSex hormone-binding globulincarrier
DB13943Testosterone cypionateCytochrome P450 3A5enzyme
DB13943Testosterone cypionateCytochrome P450 3A7enzyme
DB13943Testosterone cypionateSolute carrier organic anion transporter family member 1A2transporter
DB13943Testosterone cypionateSolute carrier family 22 member 8transporter
DB13943Testosterone cypionateSolute carrier family 22 member 7transporter
DB13943Testosterone cypionateP-glycoprotein 1transporter
DB13943Testosterone cypionateSodium/bile acid cotransportertransporter
DB13943Testosterone cypionateSolute carrier family 22 member 3transporter
DB13943Testosterone cypionateSolute carrier family 22 member 4transporter
DB13943Testosterone cypionateATP-binding cassette sub-family G member 2transporter
DB13943Testosterone cypionateCytochrome P450 1A1enzyme
DB13943Testosterone cypionateCytochrome P450 2A13enzyme
DB13943Testosterone cypionateCytochrome P450 2B6enzyme
DB13943Testosterone cypionateCytochrome P450 2C19enzyme
DB13943Testosterone cypionateCytochrome P450 2C8enzyme
DB13943Testosterone cypionateCytochrome P450 2C9enzyme
DB13943Testosterone cypionateCytochrome P450 3A43enzyme
DB13943Testosterone cypionateEstrogen receptor alphatarget
DB13943Testosterone cypionateMineralocorticoid receptortarget
DB13943Testosterone cypionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB13943Testosterone cypionateCytochrome P450 19A1enzyme
DB13944Testosterone enanthateAndrogen receptortarget
DB13944Testosterone enanthateCytochrome P450 3A4enzyme
DB13944Testosterone enanthateAmine oxidase [flavin-containing] Aenzyme
DB13944Testosterone enanthateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB13944Testosterone enanthateSerum albumincarrier
DB13944Testosterone enanthateSex hormone-binding globulincarrier
DB13944Testosterone enanthateCytochrome P450 3A5enzyme
DB13944Testosterone enanthateCytochrome P450 3A7enzyme
DB13944Testosterone enanthateSolute carrier organic anion transporter family member 1A2transporter
DB13944Testosterone enanthateSolute carrier family 22 member 8transporter
DB13944Testosterone enanthateSolute carrier family 22 member 7transporter
DB13944Testosterone enanthateP-glycoprotein 1transporter
DB13944Testosterone enanthateSodium/bile acid cotransportertransporter
DB13944Testosterone enanthateSolute carrier family 22 member 3transporter
DB13944Testosterone enanthateSolute carrier family 22 member 4transporter
DB13944Testosterone enanthateATP-binding cassette sub-family G member 2transporter
DB13944Testosterone enanthateCytochrome P450 1A1enzyme
DB13944Testosterone enanthateCytochrome P450 2A13enzyme
DB13944Testosterone enanthateCytochrome P450 2B6enzyme
DB13944Testosterone enanthateCytochrome P450 2C19enzyme
DB13944Testosterone enanthateCytochrome P450 2C8enzyme
DB13944Testosterone enanthateCytochrome P450 2C9enzyme
DB13944Testosterone enanthateCytochrome P450 3A43enzyme
DB13944Testosterone enanthateEstrogen receptor alphatarget
DB13944Testosterone enanthateMineralocorticoid receptortarget
DB13944Testosterone enanthate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB13944Testosterone enanthateCytochrome P450 19A1enzyme
DB13946Testosterone undecanoateAndrogen receptortarget
DB13946Testosterone undecanoateCytochrome P450 3A4enzyme
DB13946Testosterone undecanoateAmine oxidase [flavin-containing] Aenzyme
DB13946Testosterone undecanoateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB13946Testosterone undecanoateSerum albumincarrier
DB13946Testosterone undecanoateSex hormone-binding globulincarrier
DB13946Testosterone undecanoateCytochrome P450 3A5enzyme
DB13946Testosterone undecanoateCytochrome P450 3A7enzyme
DB13946Testosterone undecanoateSolute carrier organic anion transporter family member 1A2transporter
DB13946Testosterone undecanoateSolute carrier family 22 member 8transporter
DB13946Testosterone undecanoateSolute carrier family 22 member 7transporter
DB13946Testosterone undecanoateP-glycoprotein 1transporter
DB13946Testosterone undecanoateSodium/bile acid cotransportertransporter
DB13946Testosterone undecanoateSolute carrier family 22 member 4transporter
DB13946Testosterone undecanoateATP-binding cassette sub-family G member 2transporter
DB13946Testosterone undecanoateCytochrome P450 1A1enzyme
DB13946Testosterone undecanoateCytochrome P450 1B1enzyme
DB13946Testosterone undecanoateCytochrome P450 2A13enzyme
DB13946Testosterone undecanoateCytochrome P450 2B6enzyme
DB13946Testosterone undecanoateCytochrome P450 2C19enzyme
DB13946Testosterone undecanoateCytochrome P450 2C8enzyme
DB13946Testosterone undecanoateCytochrome P450 2C9enzyme
DB13946Testosterone undecanoateCytochrome P450 3A43enzyme
DB13946Testosterone undecanoateEstrogen receptor alphatarget
DB13946Testosterone undecanoateMineralocorticoid receptortarget
DB13946Testosterone undecanoate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
DB13946Testosterone undecanoateSolute carrier family 22 member 2transporter
DB13946Testosterone undecanoateMultidrug and toxin extrusion protein 1transporter
DB13946Testosterone undecanoateSolute carrier organic anion transporter family member 1B3transporter
DB13946Testosterone undecanoateCytochrome P450 19A1enzyme
DrugDrug NamePhaseStatusCount
DB01006Letrozole3Completed1
DB00624Testosterone4Completed2