Dyslipidemias

Also known as: Dyslipidemia / Dyslipidaemias / Dyslipidaemia

DrugDrug NameDrug Description
DB00227LovastatinLovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. It was the second agent of this class discovered. It was discovered by Alfred Alberts and his team at Merck in 1978 after screening only 18 compounds over 2 weeks. The agent, also known as mevinolin, was isolated from the fungi Aspergillus terreus. Research on this compound was suddenly shut down in 1980 and the drug was not approved until 1987. Interesting, Akira Endo at Sankyo Co. (Japan) patented lovastatin isolated from Monascus ruber four months before Merck. Lovastatin was found to be 2 times more potent than its predecessor, mevastatin, the first discovered statin. Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at the 6’ position. Lovastatin is a prodrug that is activated by in vivo hydrolysis of the lactone ring. It, along with mevastatin, has served as one of the lead compounds for the development of the synthetic compounds used today.
DrugDrug NamePhaseStatusCount
DB00635Prednisone0Not Yet Recruiting1
DB00173Adenine1Completed1
DB06630Anacetrapib1Completed3
DB01076Atorvastatin1Completed2
DB01076Atorvastatin1Recruiting1
DB12456Bococizumab1Completed3
DB01166Cilostazol1Recruiting1
DB11655Evacetrapib1Completed1
DB00973Ezetimibe1Completed2
DB01039Fenofibrate1Completed1
DB12990Icosabutate1Recruiting1
DB00218Moxifloxacin1Completed2
DB00218Moxifloxacin1Recruiting1
DB00627Niacin1Completed2
DB00627Niacin1Recruiting1
DB00175Pravastatin1Recruiting1
DB00172Proline1Recruiting1
DB01098Rosuvastatin1Completed2
DB01098Rosuvastatin1Recruiting1
DB00133Serine1Recruiting1
DB00641Simvastatin1Completed2
DB00641Simvastatin1Recruiting1
DB12000Apabetalone1 / 2Completed1
DB01039Fenofibrate1 / 2Completed1
DB09302Alirocumab2Not Yet Recruiting1
DB06630Anacetrapib2Completed1
DB12000Apabetalone2Completed1
DB12000Apabetalone2Terminated1
DB01076Atorvastatin2Completed8
DB01076Atorvastatin2Not Yet Recruiting1
DB01076Atorvastatin2Recruiting1
DB01076Atorvastatin2Terminated1
DB11936Bempedoic acid2Completed1
DB12456Bococizumab2Completed2
DB09061Cannabidiol2Completed1
DB13015Cardarine2Completed1
DB00608Chloroquine2Active Not Recruiting1
DB06311Darapladib2Completed1
DB12486Elobixibat2Completed1
DB05035Eprotirome2Completed1
DB11655Evacetrapib2Completed2
DB00973Ezetimibe2Completed2
DB01039Fenofibrate2Completed3
DB01039Fenofibrate2Terminated1
DB12627GSK-12922632Completed1
DB05769LCP-AtorFen2Completed1
DB12270Losmapimod2Completed1
DB05528Mipomersen2Completed3
DB00627Niacin2Completed2
DB00175Pravastatin2Completed1
DB02709Resveratrol2Completed1
DB01098Rosuvastatin2Completed2
DB01098Rosuvastatin2Not Yet Recruiting1
DB01098Rosuvastatin2Terminated1
DB00641Simvastatin2Completed3
DB11755Tetrahydrocannabivarin2Completed1
DB01076Atorvastatin2 / 3Completed1
DB06774Capsaicin2 / 3Not Yet Recruiting1
DB11121Chloroxylenol2 / 3Not Yet Recruiting1
DB01039Fenofibrate2 / 3Completed1
DB01039Fenofibrate2 / 3Terminated1
DB05769LCP-AtorFen2 / 3Completed1
DB00331Metformin2 / 3Terminated1
DB06510Muraglitazar2 / 3Completed1
DB00945Acetylsalicylic acid3Completed2
DB09302Alirocumab3Recruiting1
DB00381Amlodipine3Completed2
DB00381Amlodipine3Recruiting1
DB06630Anacetrapib3Completed1
DB01076Atorvastatin3Active Not Recruiting1
DB01076Atorvastatin3Completed15
DB01076Atorvastatin3Recruiting2
DB01076Atorvastatin3Terminated2
DB12456Bococizumab3Terminated1
DB11121Chloroxylenol3Completed1
DB00169Cholecalciferol3Recruiting1
DB11634Colestilan chloride3Completed1
DB09303Evolocumab3Active Not Recruiting2
DB09303Evolocumab3Completed2
DB00973Ezetimibe3Completed3
DB00973Ezetimibe3Terminated1
DB01039Fenofibrate3Completed10
DB09279Fimasartan3Recruiting1
DB13961Fish oil3Completed1
DB01095Fluvastatin3Completed1
DB00222Glimepiride3Completed1
DB12788Glucagon-like peptide II3Completed1
DB00451Levothyroxine3Unknown Status1
DB12055MK-07673Terminated1
DB00331Metformin3Completed4
DB00331Metformin3Recruiting1
DB05528Mipomersen3Completed2
DB00627Niacin3Completed2
DB00275Olmesartan3Completed1
DB11133Omega-3 fatty acids3Completed1
DB01132Pioglitazone3Completed1
DB08860Pitavastatin3Completed9
DB08860Pitavastatin3Recruiting1
DB08860Pitavastatin3Terminated2
DB06155Rimonabant3Completed2
DB06155Rimonabant3Terminated2
DB00412Rosiglitazone3Terminated1
DB01098Rosuvastatin3Completed14
DB01098Rosuvastatin3Not Yet Recruiting2
DB01098Rosuvastatin3Recruiting1
DB00641Simvastatin3Completed10
DB00641Simvastatin3Terminated3
DB05317TAK-4753Completed2
DB00966Telmisartan3Completed2
DB06281Torcetrapib3Completed1
DB06281Torcetrapib3Terminated2
DB00177Valsartan3Completed2
DB00945Acetylsalicylic acid4Completed1
DB09302Alirocumab4Completed1
DB09302Alirocumab4Not Yet Recruiting1
DB00381Amlodipine4Completed3
DB00381Amlodipine4Recruiting1
DB01238Aripiprazole4Unknown Status1
DB00174Asparagine4Completed1
DB01072Atazanavir4Completed1
DB01076Atorvastatin4Active Not Recruiting1
DB01076Atorvastatin4Completed17
DB01076Atorvastatin4Not Yet Recruiting1
DB01076Atorvastatin4Recruiting3
DB11121Chloroxylenol4Terminated1
DB09064Ciprofibrate4Completed1
DB00930Colesevelam4Completed2
DB00879Emtricitabine4Completed1
DB00973Ezetimibe4Completed3
DB00973Ezetimibe4Not Yet Recruiting1
DB00973Ezetimibe4Withdrawn1
DB01039Fenofibrate4Completed6
DB01039Fenofibrate4Terminated1
DB01095Fluvastatin4Completed4
DB00117Histidine4Completed1
DB01029Irbesartan4Completed1
DB00709Lamivudine4Completed1
DB11629Laropiprant4Terminated1
DB01601Lopinavir4Completed1
DB00227Lovastatin4Completed1
DB00331Metformin4Active Not Recruiting1
DB00331Metformin4Completed1
DB00627Niacin4Completed3
DB00627Niacin4Terminated2
DB00627Niacin4Unknown Status1
DB11133Omega-3 fatty acids4Completed2
DB09539Omega-3-acid ethyl esters4Completed1
DB00790Perindopril4Recruiting1
DB01132Pioglitazone4Completed1
DB08860Pitavastatin4Active Not Recruiting1
DB08860Pitavastatin4Completed2
DB08860Pitavastatin4Recruiting1
DB00175Pravastatin4Completed2
DB00503Ritonavir4Completed1
DB01098Rosuvastatin4Active Not Recruiting1
DB01098Rosuvastatin4Completed3
DB01098Rosuvastatin4Recruiting1
DB01098Rosuvastatin4Terminated1
DB01098Rosuvastatin4Unknown Status1
DB00641Simvastatin4Completed4
DB00641Simvastatin4Unknown Status1
DB00641Simvastatin4Withdrawn1
DB00966Telmisartan4Not Yet Recruiting1
DB00300Tenofovir disoproxil4Completed1
DB00177Valsartan4Completed1
DB00163Vitamin E4Recruiting1
DB00495Zidovudine4Completed1
DB13015CardarineNot AvailableCompleted1
DB00608ChloroquineNot AvailableActive Not Recruiting1
DB00625EfavirenzNot AvailableActive Not Recruiting1
DB00879EmtricitabineNot AvailableActive Not Recruiting1
DB00973EzetimibeNot AvailableCompleted1
DB00973EzetimibeNot AvailableRecruiting1
DB01039FenofibrateNot AvailableUnknown Status1
DB00502HaloperidolNot AvailableCompleted2
DB00451LevothyroxineNot AvailableNot Yet Recruiting1
DB00627NiacinNot AvailableCompleted2
DB00334OlanzapineNot AvailableCompleted1
DB08860PitavastatinNot AvailableNot Yet Recruiting2
DB00175PravastatinNot AvailableUnknown Status1
DB08864RilpivirineNot AvailableActive Not Recruiting1
DB00641SimvastatinNot AvailableCompleted1
DB00966TelmisartanNot AvailableUnknown Status1
DB00300Tenofovir disoproxilNot AvailableCompleted1