Colorectal Polyps

Also known as: Colorectal polyps / Colonic Polyps / Colonic Polyp / Colorectal Polyp / Rectal Polyp / Anal polyp / Rectal Polyps / Polyp colorectal / Large intestine polyp / Polyp of large intestine

DrugDrug NameDrug Description
DB00605SulindacSulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
DrugDrug NamePhaseStatusCount
DB00136Calcitriol1Completed1
DB01373Calcium1Completed1
DB11577Indigotindisulfonic Acid1Completed1
DB00158Folic acid2Completed1
DB06716Fospropofol2 / 3Completed1
DB00683Midazolam2 / 3Completed1
DB09106Hydroxyethyl Starch3Completed1
DB00825Levomenthol3Terminated1
DB11198Peppermint oil3Terminated1
DB00668Epinephrine4Not Yet Recruiting1
DB11675Mosapride4Active Not Recruiting1
DB09287Polyethylene glycol4Active Not Recruiting1
DB00945Acetylsalicylic acidNot AvailableEnrolling by Invitation1
DB09020BisacodylNot AvailableCompleted1
DB09374Indocyanine green acid formNot AvailableCompleted1